Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0226 | 0.009 | 0.1617 |
Mycobacterium ulcerans | peptide deformylase | 0.9923 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0675 | 0.0548 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0226 | 0.009 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0048 | 0.0632 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0048 | 0.0632 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3787 | 0.3728 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0421 | 0.0288 | 1 |
Plasmodium falciparum | peptide deformylase | 0.9923 | 1 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0199 | 0.0061 | 0.0315 |
Onchocerca volvulus | 0.0263 | 0.0127 | 0.3431 | |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Onchocerca volvulus | Matrilysin homolog | 0.0412 | 0.0279 | 1 |
Brugia malayi | Matrixin family protein | 0.0449 | 0.0317 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0449 | 0.0317 | 0.4164 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0186 | 0.0048 | 0.0632 |
Echinococcus multilocularis | adam 17 protease | 0.0421 | 0.0288 | 0.4829 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0046 | 0.0599 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0226 | 0.009 | 0.0044 |
Treponema pallidum | polypeptide deformylase (def) | 0.9923 | 1 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0199 | 0.0061 | 0.0315 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9923 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.9923 | 1 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.9923 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9923 | 1 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3787 | 0.3728 | 0.5 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3787 | 0.3728 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0186 | 0.0048 | 0.1519 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3787 | 0.3728 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0264 | 0.0128 | 0.1643 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0199 | 0.0061 | 0.1988 |
Mycobacterium tuberculosis | Possible exported protein | 0.1491 | 0.1382 | 0.1343 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9923 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0412 | 0.0279 | 0.3666 |
Loa Loa (eye worm) | hypothetical protein | 0.0884 | 0.0762 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.0127 | 0.4319 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0183 | 0.0046 | 0.1429 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0046 | 0.0599 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0412 | 0.0279 | 1 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3787 | 0.3728 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3787 | 0.3728 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0226 | 0.009 | 0.0044 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.009 | 0.1175 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.0046 | 0.0599 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0199 | 0.0061 | 0.0583 |
Echinococcus granulosus | adam 17 protease | 0.0463 | 0.0331 | 0.5681 |
Brugia malayi | Matrixin family protein | 0.0186 | 0.0048 | 0.0094 |
Brugia malayi | Hemopexin family protein | 0.0263 | 0.0127 | 0.3014 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0048 | 0.0632 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0264 | 0.0128 | 0.1643 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3787 | 0.3728 | 0.5 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0675 | 0.0548 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 1.9 uM l-1 | The inotropic activity of the compound was assayed in vitro in cat papillary muscle | ChEMBL. | 2832602 |
EC50 (functional) | = 17 uM l-1 | Chronotropic effects were assayed in vitro in the isolated right artium of the cat. | ChEMBL. | 2832602 |
Ratio (functional) | = 9 | Ratio of Chronotropic (C) EC50 to inotropic (I) EC50 | ChEMBL. | 2832602 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.