Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | endothelin converting enzyme 1 | 0.0096 | 0.1151 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 0.0464 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.0464 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.0464 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1151 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0585 | 0.0667 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0177 | 0.3091 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0177 | 0.3091 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0177 | 0.3091 | 0.5 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0177 | 0.3091 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0585 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0585 | 0.0667 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0177 | 0.3091 | 0.5 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0177 | 0.3091 | 0.5 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0096 | 0.1151 | 0.5 |
Echinococcus multilocularis | endothelin converting enzyme 1 | 0.0096 | 0.1151 | 0.5 |
Toxoplasma gondii | hypothetical protein | 0.0464 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0096 | 0.1151 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.0464 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0585 | 0.0667 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0585 | 0.0667 |
Treponema pallidum | polypeptide deformylase (def) | 0.0464 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.0585 | 0.0667 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0096 | 0.1151 | 1 |
Brugia malayi | Peptidase family M13 containing protein | 0.0096 | 0.1151 | 0.5 |
Plasmodium falciparum | peptide deformylase | 0.0464 | 1 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0177 | 0.3091 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -67 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM | ChEMBL. | 12593659 |
Change (functional) | = -67 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM | ChEMBL. | 12593659 |
Change (functional) | = -14 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM | ChEMBL. | 12593659 |
Change (functional) | = -14 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM | ChEMBL. | 12593659 |
Change (functional) | = 3 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM | ChEMBL. | 12593659 |
Change (functional) | = 3 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM | ChEMBL. | 12593659 |
Change (functional) | = 19 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM | ChEMBL. | 12593659 |
Change (functional) | = 19 % | Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM | ChEMBL. | 12593659 |
Inhibition (binding) | = 0 % | Ability to displace the binding of [3H]-DPCPX to the ligand binding site of CHO:hA1 (human Adenosine A1 receptor) at concentration of 10 microM | ChEMBL. | 12593659 |
Inhibition (binding) | = 0 % | Ability to displace the binding of [3H]-ZM 241385, to the ligand binding site of CHO:hA2A (human Adenosine A2A receptor) at concentration of 10 microM | ChEMBL. | 12593659 |
Inhibition (binding) | = 0 % | Ability to displace the binding of [3H]-DPCPX to the ligand binding site of CHO:hA1 (human Adenosine A1 receptor) at concentration of 10 microM | ChEMBL. | 12593659 |
Inhibition (binding) | = 0 % | Ability to displace the binding of [3H]-ZM 241385, to the ligand binding site of CHO:hA2A (human Adenosine A2A receptor) at concentration of 10 microM | ChEMBL. | 12593659 |
Inhibition (binding) | = 22 % | Ability to displace the binding of [3H]-MRE 3008-F20 to the ligand binding site of CHO:hA3 (human Adenosine receptor) at concentration of 10 microM | ChEMBL. | 12593659 |
Inhibition (binding) | = 22 % | Ability to displace the binding of [3H]-MRE 3008-F20 to the ligand binding site of CHO:hA3 (human Adenosine receptor) at concentration of 10 microM | ChEMBL. | 12593659 |
K-1 decrease (binding) | = 4 % | Dissociation of [3H]-CCPA from Adenosine A1 receptor in CHO cells at 10 uM as percent K-1 | ChEMBL. | 12593659 |
K-1 decrease (binding) | = 4 % | Dissociation of [3H]-CCPA from Adenosine A1 receptor in CHO cells at 10 uM as percent K-1 | ChEMBL. | 12593659 |
T1/2 increase (binding) | = 4 % | Dissociation rate of [3H]-CCPA from Adenosine A1 receptor expressing CHO cells at 10 uM as percent t1/2 | ChEMBL. | 12593659 |
T1/2 increase (binding) | = 4 % | Dissociation rate of [3H]-CCPA from Adenosine A1 receptor expressing CHO cells at 10 uM as percent t1/2 | ChEMBL. | 12593659 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.