TDR Targets

Basic information

Technical information

TDR Targets ID: 286364
Name: (2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen -3-yl)-(4-bromonaphthalen-1-yl)methanone
MW: 372.279 | Formula: C18H14BrNOS
H donors: 1 H acceptors: 1 LogP: 5.78 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: Nc1sc2c(c1C(=O)c1ccc(c3c1cccc3)Br)CCC2
InChi: 1S/C18H14BrNOS/c19-14-9-8-12(10-4-1-2-5-11(10)14)17(21)16-13-6-3-7-15(13)22-18(16)20/h1-2,4-5,8-9H,3,6-7,20H2
InChiKey: ADDRIEYGNGIDID-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

(2-amino-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-bromo-1-naphthyl)methanone
(2-azanyl-5,6-dihydro-4H-cyclopenta[b]thiophen-3-yl)-(4-bromonaphthalen-1-yl)methanone
(2-amino-5,6-dihydro-4H-cyclopenta[d]thiophen-3-yl)-(4-bromonaphthalen-1-yl)methanone
(2-amino-5,6-dihydro-4H-cyclopenta[d]thiophen-3-yl)-(4-bromo-1-naphthyl)methanone

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0585	0.0667
Plasmodium vivax	peptide deformylase, putative	0.0464	1	0.5
Trypanosoma brucei	Polypeptide deformylase 1	0.0177	0.3091	0.5
Mycobacterium tuberculosis	Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase)	0.0464	1	1
Echinococcus granulosus	endothelin converting enzyme 1	0.0096	0.1151	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0585	0.0667
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0177	0.3091	0.5
Treponema pallidum	polypeptide deformylase (def)	0.0464	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0585	0.0667
Brugia malayi	Hypothetical zinc metalloproteinase T16A9.4	0.0096	0.1151	0.5
Schistosoma mansoni	family M13 unassigned peptidase (M13 family)	0.0096	0.1151	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0585	0.0667
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0177	0.3091	0.5
Trypanosoma cruzi	Peptide deformylase 2, putative	0.0177	0.3091	0.5
Mycobacterium leprae	PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE)	0.0464	1	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1151	1
Trypanosoma brucei	Peptide deformylase 2	0.0177	0.3091	0.5
Toxoplasma gondii	hypothetical protein	0.0464	1	1
Wolbachia endosymbiont of Brugia malayi	peptide deformylase	0.0464	1	0.5
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0585	0.0667
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1151	1
Loa Loa (eye worm)	hypothetical protein	0.0096	0.1151	1
Loa Loa (eye worm)	hypothetical protein	0.0073	0.0585	0.0667
Plasmodium falciparum	peptide deformylase	0.0464	1	0.5
Brugia malayi	Peptidase family M13 containing protein	0.0096	0.1151	0.5
Trypanosoma cruzi	polypeptide deformylase-like protein, putative	0.0177	0.3091	0.5
Mycobacterium ulcerans	peptide deformylase	0.0464	1	1
Echinococcus multilocularis	endothelin converting enzyme 1	0.0096	0.1151	0.5
Leishmania major	polypeptide deformylase-like protein, putative	0.0177	0.3091	0.5

Activities

Activity type	Activity value	Assay description	Source	Reference
Change (functional)	= -67 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM	ChEMBL.	12593659
Change (functional)	= -67 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 10 uM	ChEMBL.	12593659
Change (functional)	= -14 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM	ChEMBL.	12593659
Change (functional)	= -14 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 1 uM	ChEMBL.	12593659
Change (functional)	= 3 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM	ChEMBL.	12593659
Change (functional)	= 3 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.01 uM	ChEMBL.	12593659
Change (functional)	= 19 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM	ChEMBL.	12593659
Change (functional)	= 19 %	Percent change in cAMP content of CHO (Chinese hamster ovary) cells expressing human Adenosine A1 receptor at 0.1 uM	ChEMBL.	12593659
Inhibition (binding)	= 0 %	Ability to displace the binding of [3H]-DPCPX to the ligand binding site of CHO:hA1 (human Adenosine A1 receptor) at concentration of 10 microM	ChEMBL.	12593659
Inhibition (binding)	= 0 %	Ability to displace the binding of [3H]-ZM 241385, to the ligand binding site of CHO:hA2A (human Adenosine A2A receptor) at concentration of 10 microM	ChEMBL.	12593659
Inhibition (binding)	= 0 %	Ability to displace the binding of [3H]-DPCPX to the ligand binding site of CHO:hA1 (human Adenosine A1 receptor) at concentration of 10 microM	ChEMBL.	12593659
Inhibition (binding)	= 0 %	Ability to displace the binding of [3H]-ZM 241385, to the ligand binding site of CHO:hA2A (human Adenosine A2A receptor) at concentration of 10 microM	ChEMBL.	12593659
Inhibition (binding)	= 22 %	Ability to displace the binding of [3H]-MRE 3008-F20 to the ligand binding site of CHO:hA3 (human Adenosine receptor) at concentration of 10 microM	ChEMBL.	12593659
Inhibition (binding)	= 22 %	Ability to displace the binding of [3H]-MRE 3008-F20 to the ligand binding site of CHO:hA3 (human Adenosine receptor) at concentration of 10 microM	ChEMBL.	12593659
K-1 decrease (binding)	= 4 %	Dissociation of [3H]-CCPA from Adenosine A1 receptor in CHO cells at 10 uM as percent K-1	ChEMBL.	12593659
K-1 decrease (binding)	= 4 %	Dissociation of [3H]-CCPA from Adenosine A1 receptor in CHO cells at 10 uM as percent K-1	ChEMBL.	12593659
T1/2 increase (binding)	= 4 %	Dissociation rate of [3H]-CCPA from Adenosine A1 receptor expressing CHO cells at 10 uM as percent t1/2	ChEMBL.	12593659
T1/2 increase (binding)	= 4 %	Dissociation rate of [3H]-CCPA from Adenosine A1 receptor expressing CHO cells at 10 uM as percent t1/2	ChEMBL.	12593659

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL434692
PubChem: 10292653

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 286364