Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Oryctolagus cuniculus | Acyl-CoA:cholesterol acyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma mansoni | sterol O-acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus granulosus | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Echinococcus multilocularis | sterol O acyltransferase 1 | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Schistosoma japonicum | ko:K00637 sterol O-acyltransferase [EC2.3.1.26], putative | Get druggable targets OG5_133487 | All targets in OG5_133487 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Dictyostelium discoideum | diacylglycerol O-acyltransferase 1 | Acyl-CoA:cholesterol acyltransferase | 305 aa | 278 aa | 21.9 % |
Neospora caninum | sterol O-acyltransferase, putative | Acyl-CoA:cholesterol acyltransferase | 305 aa | 258 aa | 20.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.0439 | 0.0599 |
Echinococcus granulosus | acetylcholinesterase | 0.0132 | 0.0439 | 0.0599 |
Echinococcus multilocularis | tumor suppressor p53 binding protein 1 | 0.0318 | 0.5622 | 0.768 |
Onchocerca volvulus | 0.0116 | 0 | 0.5 | |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0379 | 0.732 | 1 |
Echinococcus granulosus | sterol O acyltransferase 1 | 0.0264 | 0.4119 | 0.5627 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0132 | 0.0439 | 0.0599 |
Echinococcus multilocularis | sterol O acyltransferase 1 | 0.0264 | 0.4119 | 0.5627 |
Schistosoma mansoni | glutaminase | 0.0281 | 0.4592 | 0.4592 |
Echinococcus granulosus | carboxylesterase 5A | 0.0132 | 0.0439 | 0.0599 |
Loa Loa (eye worm) | glutaminase 2 | 0.0281 | 0.4592 | 1 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0132 | 0.0439 | 0.0439 |
Echinococcus granulosus | tumor suppressor p53 binding protein 1 | 0.0318 | 0.5622 | 0.768 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.0439 | 0.0599 |
Loa Loa (eye worm) | hypothetical protein | 0.0238 | 0.34 | 0.7129 |
Brugia malayi | glutaminase DH11.1 | 0.0281 | 0.4592 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0264 | 0.4119 | 0.886 |
Mycobacterium ulcerans | glutaminase | 0.0281 | 0.4592 | 0.5 |
Schistosoma mansoni | sterol O-acyltransferase 1 | 0.0264 | 0.4119 | 0.4119 |
Trichomonas vaginalis | glutaminase, putative | 0.0281 | 0.4592 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0318 | 0.5622 | 0.5622 |
Loa Loa (eye worm) | glutaminase | 0.0281 | 0.4592 | 1 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0379 | 0.732 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0132 | 0.0439 | 0.0599 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Change (functional) | = -61 % | Total cholesterol lowering activity of the compound tested by administered orally to rats at dose 10(mg/kg) once a day for 3 days | ChEMBL. | 8632433 |
IC50 (binding) | = 0.33 uM | Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rabbit intestine microsomes | ChEMBL. | 8632433 |
IC50 (binding) | = 0.33 uM | Inhibitory activity against Acyl coenzyme A:cholesterol acyltransferase 1 obtained from rabbit intestine microsomes | ChEMBL. | 8632433 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.