Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Echinococcus multilocularis | tachykinin peptides receptor 99D | 0.0797 | 0.5993 | 0.6087 |
Echinococcus granulosus | histone deacetylase 8 | 0.0217 | 0.046 | 0.0467 |
Schistosoma mansoni | histone deacetylase | 0.0449 | 0.2672 | 0.3045 |
Loa Loa (eye worm) | histone deacetylase 11 | 0.0217 | 0.046 | 0.046 |
Trypanosoma brucei | histone deacetylase 4 | 0.0462 | 0.2802 | 0.2817 |
Entamoeba histolytica | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Brugia malayi | fructose-1,6-bisphosphatase | 0.1089 | 0.8773 | 0.8773 |
Schistosoma mansoni | peptide (allatostatin)-like receptor | 0.031 | 0.1353 | 0.1542 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0462 | 0.2802 | 0.3194 |
Echinococcus granulosus | histone deacetylase 6 | 0.0475 | 0.2922 | 0.2968 |
Echinococcus granulosus | histone deacetylase 3 | 0.0449 | 0.2672 | 0.2713 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0475 | 0.2922 | 0.2968 |
Echinococcus multilocularis | allatostatin A receptor | 0.031 | 0.1353 | 0.1374 |
Loa Loa (eye worm) | hypothetical protein | 0.0449 | 0.2672 | 0.2672 |
Schistosoma mansoni | histone deacetylase 1 2 3 | 0.0217 | 0.046 | 0.0525 |
Plasmodium vivax | histone deacetylase 2, putative | 0.0462 | 0.2802 | 1 |
Echinococcus multilocularis | histone deacetylase 7 | 0.0462 | 0.2802 | 0.2846 |
Trypanosoma brucei | histone deacetylase 1 | 0.0449 | 0.2672 | 0.266 |
Loa Loa (eye worm) | fructose-1,6-bisphosphatase | 0.1089 | 0.8773 | 0.8773 |
Brugia malayi | histone deacetylase 11 | 0.0217 | 0.046 | 0.046 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0462 | 0.2802 | 0.2817 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Echinococcus granulosus | tachykinin peptides receptor 99D | 0.0797 | 0.5993 | 0.6087 |
Trypanosoma brucei | histone deacetylase 3 | 0.0462 | 0.2802 | 0.2817 |
Plasmodium vivax | histone deacetylase 1, putative | 0.0449 | 0.2672 | 0.9442 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0449 | 0.2672 | 0.5 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0475 | 0.2922 | 0.3331 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1089 | 0.8773 | 1 |
Plasmodium vivax | histone deacetylase, putative | 0.0462 | 0.2802 | 1 |
Plasmodium falciparum | histone deacetylase, putative | 0.0462 | 0.2802 | 1 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.1202 | 0.9846 | 1 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0462 | 0.2802 | 0.2817 |
Trypanosoma cruzi | histone deacetylase, putative | 0.0462 | 0.2802 | 0.2817 |
Loa Loa (eye worm) | histone deacetylase 1 | 0.0449 | 0.2672 | 0.2672 |
Toxoplasma gondii | histone deacetylase HDAC2 | 0.0449 | 0.2672 | 0.266 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0462 | 0.2802 | 0.2846 |
Giardia lamblia | Histone deacetylase | 0.0449 | 0.2672 | 0.5 |
Trypanosoma brucei | fructose-1,6-bisphosphatase | 0.1089 | 0.8773 | 1 |
Trypanosoma brucei | histone deacetylase, putative | 0.0462 | 0.2802 | 0.2817 |
Loa Loa (eye worm) | histone deacetylase 3 | 0.0449 | 0.2672 | 0.2672 |
Toxoplasma gondii | sedoheptulose-1,7-bisphosphatase | 0.0405 | 0.2256 | 0.216 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0405 | 0.2256 | 0.216 |
Schistosoma mansoni | histone deacetylase | 0.0449 | 0.2672 | 0.3045 |
Trypanosoma cruzi | fructose-1,6-bisphosphatase, cytosolic, putative | 0.1089 | 0.8773 | 1 |
Toxoplasma gondii | histone deacetylase HDAC3 | 0.0449 | 0.2672 | 0.266 |
Trypanosoma brucei | sedoheptulose-1,7-bisphosphatase | 0.0405 | 0.2256 | 0.216 |
Echinococcus multilocularis | histone deacetylase 3 | 0.0449 | 0.2672 | 0.2713 |
Schistosoma mansoni | histone deacetylase 4 5 | 0.0462 | 0.2802 | 0.3194 |
Leishmania major | histone deacetylase, putative | 0.0462 | 0.2802 | 0.0214 |
Brugia malayi | Histone deacetylase 1 | 0.0449 | 0.2672 | 0.2672 |
Loa Loa (eye worm) | hypothetical protein | 0.0217 | 0.046 | 0.046 |
Onchocerca volvulus | 0.031 | 0.1353 | 1 | |
Trichomonas vaginalis | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0449 | 0.2672 | 0.5 |
Echinococcus granulosus | fructose 16 bisphosphatase 1 | 0.1089 | 0.8773 | 0.891 |
Trichomonas vaginalis | histone deacetylase 1, 2 ,3, putative | 0.0449 | 0.2672 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1218 | 1 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1202 | 0.9846 | 1 |
Plasmodium falciparum | histone deacetylase 2 | 0.0462 | 0.2802 | 1 |
Loa Loa (eye worm) | histone deacetylase | 0.0462 | 0.2802 | 0.2802 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0449 | 0.2672 | 0.266 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Loa Loa (eye worm) | histone deacetylase 7A | 0.0462 | 0.2802 | 0.2802 |
Echinococcus multilocularis | histone deacetylase 6 | 0.0462 | 0.2802 | 0.2846 |
Echinococcus granulosus | nuclear receptor co repressor related ncor | 0.0561 | 0.3741 | 0.3799 |
Echinococcus multilocularis | histone deacetylase | 0.0462 | 0.2802 | 0.2846 |
Brugia malayi | Histone deacetylase family protein | 0.0462 | 0.2802 | 0.2802 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0859 | 0.0859 |
Echinococcus multilocularis | histone deacetylase 8 | 0.0217 | 0.046 | 0.0467 |
Loa Loa (eye worm) | hypothetical protein | 0.0246 | 0.0739 | 0.0739 |
Echinococcus granulosus | allatostatin A receptor | 0.031 | 0.1353 | 0.1374 |
Brugia malayi | Histone deacetylase family protein | 0.0462 | 0.2802 | 0.2802 |
Leishmania major | histone deacetylase, putative | 0.0462 | 0.2802 | 0.0214 |
Echinococcus multilocularis | histone deacetylase 1 | 0.0449 | 0.2672 | 0.2713 |
Toxoplasma gondii | fructose-bisphospatase II | 0.1089 | 0.8773 | 1 |
Brugia malayi | sulfakinin receptor protein | 0.1218 | 1 | 1 |
Leishmania major | 0.1089 | 0.8773 | 1 | |
Echinococcus granulosus | histone deacetylase 6 | 0.0462 | 0.2802 | 0.2846 |
Echinococcus granulosus | histone deacetylase 1 | 0.0449 | 0.2672 | 0.2713 |
Brugia malayi | histone deacetylase 1 (HD1) | 0.0449 | 0.2672 | 0.2672 |
Onchocerca volvulus | Histone deacetylase 10 homolog | 0.0217 | 0.046 | 0.3401 |
Brugia malayi | histone deacetylase 3 (HD3) | 0.0449 | 0.2672 | 0.2672 |
Echinococcus granulosus | histone deacetylase 7 | 0.0462 | 0.2802 | 0.2846 |
Schistosoma mansoni | histone deacetylase hda2 | 0.0217 | 0.046 | 0.0525 |
Echinococcus multilocularis | fructose 1,6 bisphosphatase 1 | 0.1089 | 0.8773 | 0.891 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Toxoplasma gondii | histone deacetylase HDAC1 | 0.0462 | 0.2802 | 0.2817 |
Trypanosoma cruzi | histone deacetylase 1, putative | 0.0449 | 0.2672 | 0.266 |
Schistosoma mansoni | fructose-16-bisphosphatase-related | 0.1089 | 0.8773 | 1 |
Trichomonas vaginalis | histone deacetylase, putative | 0.0449 | 0.2672 | 0.5 |
Echinococcus granulosus | histone deacetylase | 0.0462 | 0.2802 | 0.2846 |
Loa Loa (eye worm) | hypothetical protein | 0.031 | 0.1353 | 0.1353 |
Echinococcus multilocularis | nuclear receptor co repressor related (ncor) | 0.0561 | 0.3741 | 0.3799 |
Trypanosoma cruzi | sedoheptulose-1,7-bisphosphatase, putative | 0.0405 | 0.2256 | 0.216 |
Echinococcus granulosus | histone deacetylase 6 | 0.0462 | 0.2802 | 0.2846 |
Toxoplasma gondii | fructose-bisphospatase I | 0.0405 | 0.2256 | 0.216 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 25 % | Percent inhibition of the leukotriene E4 (LTE4)-induced contraction of guinea pig tracheal spirals at 10 microM concentration | ChEMBL. | 2704027 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.