Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.0639 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0069 | 0.5309 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0022 | 0.013 | 0.2028 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0082 | 0.1037 | 0.1037 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0061 | 0.0728 | 0.254 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0069 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0056 | 0.0639 | 0.0639 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0069 | 0.024 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0056 | 0.0639 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0202 | 0.2865 | 0.2865 |
Brugia malayi | Sodium Bile acid symporter family protein | 0.0202 | 0.2865 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0069 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0069 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0069 | 0.024 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.013 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0069 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.012 | 0.1619 | 0.1619 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0069 | 0.5309 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.013 | 0.0452 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0202 | 0.2865 | 0.2865 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0061 | 0.0728 | 0.254 |
Trypanosoma brucei | cytochrome P450, putative | 0.0022 | 0.013 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0728 | 0.0728 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0069 | 0.5 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0022 | 0.013 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0069 | 0.5 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0069 | 0.5309 |
Loa Loa (eye worm) | TAR-binding protein | 0.0061 | 0.0728 | 0.254 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0022 | 0.013 | 0.0452 |
Echinococcus granulosus | tar DNA binding protein | 0.0061 | 0.0728 | 0.0728 |
Loa Loa (eye worm) | RNA binding protein | 0.0061 | 0.0728 | 0.254 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0069 | 0.0069 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0669 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0032 | 0.0282 | 0.0985 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0069 | 0.5 |
Brugia malayi | TAR-binding protein | 0.0061 | 0.0728 | 0.254 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.013 | 0.0452 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0728 | 0.0728 |
Mycobacterium ulcerans | short-chain type dehydrogenase/reductase | 0.0056 | 0.0639 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0202 | 0.2865 | 0.2865 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0069 | 0.1076 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0069 | 0.1076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0728 | 0.0728 |
Brugia malayi | RNA binding protein | 0.0061 | 0.0728 | 0.254 |
Loa Loa (eye worm) | hypothetical protein | 0.0202 | 0.2865 | 1 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0069 | 0.0069 |
Mycobacterium leprae | putative cytochrome p450 | 0.0014 | 0 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0022 | 0.013 | 0.0452 |
Mycobacterium tuberculosis | Probable short-chain type dehydrogenase/reductase | 0.0056 | 0.0639 | 1 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0069 | 0.0069 |
Onchocerca volvulus | 0.0202 | 0.2865 | 0.5 | |
Schistosoma mansoni | microtubule-associated protein tau | 0.0669 | 1 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0069 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0202 | 0.2865 | 0.2865 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0728 | 0.0728 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.0639 | 0.0639 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0069 | 0.1076 |
Schistosoma mansoni | tar DNA-binding protein | 0.0061 | 0.0728 | 0.0728 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0202 | 0.2865 | 0.2865 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0069 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0032 | 0.0282 | 0.0985 |
Leishmania major | cytochrome p450-like protein | 0.0022 | 0.013 | 0.2028 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0202 | 0.2865 | 0.2865 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0052 | 0.0582 | 0.2032 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0202 | 0.2865 | 0.2865 |
Echinococcus multilocularis | tar DNA binding protein | 0.0061 | 0.0728 | 0.0728 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0056 | 0.0639 | 0.2231 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0022 | 0.013 | 0.0452 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0014 | 0 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0069 | 0.0069 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0056 | 0.0639 | 0.0639 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 40 uM | In vitro cell growth inhibitory activity against wild type P388 murine leukemia cell line (P388/W) | ChEMBL. | 2153829 |
IC50 (functional) | > 40 uM | In vitro cell growth inhibitory activity against amsacrine-resistant P388 cell line (P388/A) | ChEMBL. | 2153829 |
ILS (functional) | 0 % | In vivo increased lifespan in mice implanted intraperitoneally with wild type P388 murine leukemia cell line at the optimal dose of 150 mg/kg/day; NA = not active | ChEMBL. | 2153829 |
Log KAT (binding) | = 4.87 | Binding constant to poly[d(AT)] by ethidium bromide displacement | ChEMBL. | 2153829 |
Ratio (functional) | > 1 | Ratio of IC50 value of P388/A and P388/W cell lines | ChEMBL. | 2153829 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.