Detailed information for compound 288356

Basic information

Technical information
  • TDR Targets ID: 288356
  • Name: 5-fluoro-2-methyl-3-piperidin-4-ylsulfanyl-1H -indole
  • MW: 264.362 | Formula: C14H17FN2S
  • H donors: 2 H acceptors: 0 LogP: 3.19 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1[nH]c2c(c1SC1CCNCC1)cc(cc2)F
  • InChi: 1S/C14H17FN2S/c1-9-14(18-11-4-6-16-7-5-11)12-8-10(15)2-3-13(12)17-9/h2-3,8,11,16-17H,4-7H2,1H3
  • InChiKey: PLXIUEFEICUFEZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • 5-fluoro-2-methyl-3-(4-piperidylsulfanyl)-1H-indole
  • 5-fluoro-2-methyl-3-(4-piperidinylthio)-1H-indole
  • 5-fluoro-2-methyl-3-(4-piperidylthio)-1H-indole

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0146 0.1942 0.802
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0146 0.1942 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0146 0.1942 0.1942
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0146 0.1942 0.802
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Echinococcus granulosus adenylate cyclase type IX 0.0085 0.0873 0.2868
Loa Loa (eye worm) hypothetical protein 0.0052 0.0287 0.1258
Echinococcus granulosus neuropeptide receptor A26 0.0146 0.1942 1
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0146 0.1942 1
Echinococcus multilocularis g protein coupled receptor 0.0146 0.1942 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0146 0.1942 0.8525
Echinococcus granulosus neuropeptide FF receptor 2 0.0146 0.1942 1
Echinococcus multilocularis somatostatin receptor 0.0146 0.1942 1
Echinococcus multilocularis fmrfamide receptor 0.0146 0.1942 1
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Schistosoma mansoni amine GPCR 0.0146 0.1942 1
Echinococcus multilocularis serotonin receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) melatonin receptor type 1A 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Schistosoma mansoni neuropeptide receptor 0.0146 0.1942 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0146 0.1942 0.8525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.1942 1
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Onchocerca volvulus 0.0146 0.1942 0.802
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis sex peptide receptor 0.0146 0.1942 1
Schistosoma mansoni opsin-like receptor 0.0146 0.1942 1
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.1942 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.1942 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus multilocularis neuropeptide s receptor 0.0146 0.1942 1
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.1942 1
Echinococcus multilocularis fmrfamide receptor 0.0146 0.1942 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Schistosoma mansoni hypothetical protein 0.0146 0.1942 1
Echinococcus granulosus sex peptide receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Echinococcus multilocularis g-protein coupled receptor 0.0146 0.1942 1
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0146 0.1942 1
Schistosoma mansoni myosin xvIII 0.0146 0.1942 1
Plasmodium vivax ribonucleoside-diphosphate reductase large chain, putative 0.0082 0.0819 0.5
Echinococcus granulosus g-protein coupled receptor 0.0146 0.1942 1
Echinococcus multilocularis g protein coupled receptor 0.0146 0.1942 1
Schistosoma mansoni opsin-like receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Brugia malayi Dopamine receptor 0.0146 0.1942 0.1942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus ribonucleoside diphosphate reductase large 0.0082 0.0819 0.2509
Schistosoma mansoni ribonucleoside-diphosphate reductase alpha subunit 0.0082 0.0819 0.4216
Echinococcus granulosus fmrfamide receptor 0.0146 0.1942 1
Brugia malayi Serotonin receptor 0.0146 0.1942 0.1942
Echinococcus granulosus serotonin receptor 0.0146 0.1942 1
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Brugia malayi G-protein coupled receptor 0.0146 0.1942 0.1942
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.1942 0.8525
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0146 0.1942 0.802
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.1942 1
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.1942 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Treponema pallidum ribonucleotide-diphosphate reductase subunit alpha 0.0082 0.0819 0.5
Onchocerca volvulus 0.0146 0.1942 0.802
Loa Loa (eye worm) TYRA-2 protein 0.0146 0.1942 0.8525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0146 0.1942 1
Echinococcus granulosus orexin receptor type 2 0.0146 0.1942 1
Schistosoma mansoni adenoreceptor 0.0146 0.1942 1
Echinococcus multilocularis serotonin receptor 0.0146 0.1942 1
Brugia malayi G protein-coupled receptor 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0146 0.1942 1
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis orexin receptor type 2 0.0146 0.1942 1
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Chlamydia trachomatis ribonucleoside-diphosphate reductase subunit alpha 0.0082 0.0819 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Onchocerca volvulus 0.0061 0.0443 0.0235
Brugia malayi neuropeptide F receptor 0.0146 0.1942 0.1942
Brugia malayi G protein-coupled receptor F59B2.13 0.0146 0.1942 0.1942
Onchocerca volvulus 0.0146 0.1942 0.802
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0052 0.0287 0.0287
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0146 0.1942 1
Echinococcus granulosus dro:myosuppressin receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi AKH receptor 0.0146 0.1942 0.1942
Loa Loa (eye worm) neuropeptide F receptor 0.0146 0.1942 0.8525
Onchocerca volvulus 0.0146 0.1942 0.802
Brugia malayi Calcitonin receptor-like protein seb-1 0.0052 0.0287 0.0287
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0146 0.1942 1
Brugia malayi neuropeptide F receptor 0.0146 0.1942 0.1942
Onchocerca volvulus Adenylate cyclase type 2 homolog 0.0061 0.0443 0.0235
Loa Loa (eye worm) adenylyl cyclase 3 0.0143 0.1889 0.8293
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0146 0.1942 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Schistosoma mansoni biogenic amine receptor 0.0146 0.1942 1
Echinococcus multilocularis neuropeptides capa receptor 0.0146 0.1942 1
Echinococcus multilocularis G protein coupled receptor 139 0.0146 0.1942 1
Plasmodium falciparum ribonucleoside-diphosphate reductase large subunit, putative 0.0082 0.0819 0.5
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.1942 1
Schistosoma mansoni neuropeptide F-like receptor 0.0146 0.1942 1
Brugia malayi RE15519p 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.1942 1
Schistosoma mansoni hypothetical protein 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus tachykinin peptides receptor 99D 0.0146 0.1942 1
Brugia malayi G-protein coupled receptor 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0061 0.0443 0.1943
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Trypanosoma brucei ribonucleoside-diphosphate reductase large chain 0.0082 0.0819 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0146 0.1942 0.1942
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Echinococcus granulosus tm gpcr rhodopsin 0.0146 0.1942 1
Schistosoma mansoni amine GPCR 0.0146 0.1942 1
Echinococcus granulosus G protein coupled receptor 139 0.0146 0.1942 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0146 0.1942 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0146 0.1942 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0146 0.1942 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Wolbachia endosymbiont of Brugia malayi ribonucleotide-diphosphate reductase subunit alpha 0.0082 0.0819 0.5
Brugia malayi ORL1-like opioid receptor 0.0146 0.1942 0.1942
Leishmania major ribonucleoside-diphosphate reductase large chain, putative 0.0082 0.0819 0.5
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0146 0.1942 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0146 0.1942 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0146 0.1942 0.8525
Echinococcus multilocularis neuropeptide receptor 0.0146 0.1942 1
Echinococcus multilocularis g protein coupled receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus allatostatin A receptor 0.0146 0.1942 1
Brugia malayi Dopamine receptor protein 2 0.0146 0.1942 0.1942
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.1942 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0146 0.1942 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0146 0.1942 1
Schistosoma mansoni hypothetical protein 0.0146 0.1942 1
Schistosoma mansoni histamine h1 receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Schistosoma mansoni neuropeptide receptor 0.0146 0.1942 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0146 0.1942 1
Echinococcus granulosus neuropeptide receptor 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Onchocerca volvulus Adenylate cyclase type 3 homolog 0.0168 0.2323 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus granulosus hypothetical protein 0.0146 0.1942 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0146 0.1942 0.1942
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0052 0.0287 0.1258
Mycobacterium leprae RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (ALPHA CHAIN) NRDE (RIBONUCLEOTIDE REDUCTASE SMALL SUBUNIT) (R1F PROTEIN) 0.0341 0.5354 0.5
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus peptide allatostatin:somatostatin 0.0146 0.1942 1
Brugia malayi ribonucleoside-diphosphate reductase large chain, putative 0.0082 0.0819 0.0819
Onchocerca volvulus 0.0146 0.1942 0.802
Schistosoma mansoni biogenic amine receptor 0.0146 0.1942 1
Echinococcus granulosus neuropeptide Y receptor 0.0146 0.1942 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0146 0.1942 0.8525
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Mycobacterium ulcerans ribonucleotide-diphosphate reductase subunit alpha 0.0341 0.5354 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Echinococcus granulosus g protein coupled receptor 0.0146 0.1942 1
Echinococcus granulosus g protein coupled receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0146 0.1942 1
Brugia malayi Dopamine receptor protein 1 0.0146 0.1942 0.1942
Brugia malayi Serotonin receptor 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi Tachykinin-like peptides receptor 99D 0.0146 0.1942 0.1942
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi putative neuropeptide receptor NPR1 0.0146 0.1942 0.1942
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0146 0.1942 1
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0146 0.1942 1
Echinococcus granulosus neuropeptide s receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0146 0.1942 1
Echinococcus granulosus g protein coupled receptor 0.0146 0.1942 1
Trichomonas vaginalis ribonucleoside-diphosphate reductase alpha chain, putative 0.0082 0.0819 0.5
Loa Loa (eye worm) ribonucleoside-diphosphate reductase large subunit 0.0082 0.0819 0.3594
Schistosoma mansoni biogenic amine receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Brugia malayi hypothetical protein 0.0146 0.1942 0.1942
Mycobacterium tuberculosis Ribonucleoside-diphosphate reductase (alpha chain) NrdE (ribonucleotide reductase small subunit) (R1F protein) 0.0341 0.5354 0.5
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0165 0.2278 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis ribonucleoside diphosphate reductase large 0.0082 0.0819 0.2509
Brugia malayi Adenylyl cyclase protein 0.0061 0.0443 0.0443
Echinococcus granulosus neuropeptide receptor 0.0146 0.1942 1
Schistosoma mansoni amine GPCR 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0146 0.1942 1
Brugia malayi larval opioid receptor 0.0146 0.1942 0.1942
Brugia malayi follicle stimulating hormone receptor 0.0146 0.1942 0.1942
Echinococcus granulosus alpha 1A adrenergic receptor 0.0146 0.1942 1
Schistosoma mansoni neuropeptide receptor 0.0146 0.1942 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0146 0.1942 1
Brugia malayi Melatonin receptor type 1A 0.0146 0.1942 0.1942
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis neuropeptide receptor A26 0.0146 0.1942 1
Echinococcus multilocularis adenylate cyclase type IX 0.0085 0.0873 0.2868
Onchocerca volvulus 0.0146 0.1942 0.802
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis neuropeptide FF receptor 2 0.0146 0.1942 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Toxoplasma gondii ribonucleoside-diphosphate reductase large chain 0.0082 0.0819 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0146 0.1942 1
Schistosoma mansoni neuropeptide receptor 0.0146 0.1942 1
Loa Loa (eye worm) G-protein coupled receptor 0.0146 0.1942 0.8525
Schistosoma mansoni amine GPCR 0.0146 0.1942 1
Onchocerca volvulus 0.0146 0.1942 0.802
Onchocerca volvulus 0.0146 0.1942 0.802
Brugia malayi sulfakinin receptor protein 0.0146 0.1942 0.1942
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0146 0.1942 0.8525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0146 0.1942 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0146 0.1942 1
Schistosoma mansoni opsin-like receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus granulosus somatostatin receptor 0.0146 0.1942 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0146 0.1942 1
Trypanosoma cruzi ribonucleoside-diphosphate reductase large chain, putative 0.0082 0.0819 0.5
Onchocerca volvulus 0.0146 0.1942 0.802
Schistosoma mansoni amine GPCR 0.0146 0.1942 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0146 0.1942 1
Schistosoma mansoni alpha-1 adrenergic receptor 0.0146 0.1942 1
Echinococcus multilocularis neuropeptide Y receptor 0.0146 0.1942 1
Echinococcus granulosus neuropeptides capa receptor 0.0146 0.1942 1
Brugia malayi putative neuropeptide receptor 0.0146 0.1942 0.1942
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0146 0.1942 1
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Loa Loa (eye worm) hypothetical protein 0.0146 0.1942 0.8525
Echinococcus multilocularis rhodopsin orphan GPCR 0.0146 0.1942 1
Echinococcus multilocularis allatostatin A receptor 0.0146 0.1942 1
Schistosoma mansoni hypothetical protein 0.0146 0.1942 1
Echinococcus multilocularis neuropeptide receptor 0.0146 0.1942 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0146 0.1942 1

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 5.9 mg kg-1 In vivo analgesic activity in phenylbenzoquinone-induced writhing test in mice ChEMBL. 10782691
ED50 (functional) = 5.9 mg kg-1 In vivo analgesic activity in phenylbenzoquinone-induced writhing test in mice ChEMBL. 10782691
ED50 (functional) = 12.7 mg kg-1 In vivo analgesic activity in hot plate test in mice ChEMBL. 10782691
ED50 (functional) = 12.7 mg kg-1 In vivo analgesic activity in hot plate test in mice ChEMBL. 10782691

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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