Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | thymidylate synthase | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.28 uM | Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 microM | ChEMBL. | 2704030 |
IC50 (binding) | = 0.28 uM | Inhibitory concentration of compound to inhibit Thymidylate synthase (TS) in L1210 cells at conc. of 200 microM | ChEMBL. | 2704030 |
ID50 (functional) | = 6 uM | Compound was evaluated for inhibition dose required to inhibit the growth of L1210 cells in culture. | ChEMBL. | 2704030 |
ID50 (functional) | = 6 uM | Compound was evaluated for inhibition dose required to inhibit the growth of L1210 cells in culture. | ChEMBL. | 2704030 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.