Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.2075 | 1 | 0.5 |
Onchocerca volvulus | 0.0045 | 0.0045 | 0.2115 | |
Brugia malayi | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0045 | 0.0045 | 0.0007 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0596 | 0.2747 | 0.272 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.0045 | 0.0045 | 0.0007 |
Schistosoma mansoni | amine oxidase | 0.0045 | 0.0045 | 0.0717 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0632 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0792 | 0.3707 | 1 |
Mycobacterium ulcerans | dehydrogenase | 0.0045 | 0.0045 | 0.0007 |
Plasmodium falciparum | peptide deformylase | 0.2075 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.008 | 0.0215 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0044 | 0.0038 | 0.1537 |
Echinococcus granulosus | geminin | 0.0165 | 0.0632 | 1 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0045 | 0.0045 | 0.1816 |
Loa Loa (eye worm) | matrixin family protein | 0.0087 | 0.025 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0632 | 0.1597 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0632 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Onchocerca volvulus | 0.0051 | 0.0074 | 0.3431 | |
Treponema pallidum | polypeptide deformylase (def) | 0.2075 | 1 | 0.5 |
Mycobacterium ulcerans | monoamine oxidase | 0.0045 | 0.0045 | 0.0007 |
Toxoplasma gondii | hypothetical protein | 0.2075 | 1 | 1 |
Mycobacterium ulcerans | peptide deformylase | 0.2075 | 1 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.2075 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Plasmodium vivax | peptide deformylase, putative | 0.2075 | 1 | 1 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0794 | 0.3721 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.0792 | 0.3707 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.0792 | 0.3707 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.0045 | 0.0045 | 0.0717 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0085 | 0.0242 | 0.3829 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.0045 | 0.0045 | 0.0007 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.0038 | 0.1537 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.0792 | 0.3707 | 1 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.2075 | 1 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0131 | 0.0464 | 0.114 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Loa Loa (eye worm) | matrixin family protein | 0.008 | 0.0215 | 0.859 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0641 | 0.2969 | 0.2942 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0131 | 0.0464 | 0.7135 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.0792 | 0.3707 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0792 | 0.3707 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0051 | 0.0074 | 0.1164 |
Brugia malayi | Hemopexin family protein | 0.0051 | 0.0074 | 0.2947 |
Schistosoma mansoni | amine oxidase | 0.0045 | 0.0045 | 0.0717 |
Loa Loa (eye worm) | hypothetical protein | 0.0045 | 0.0045 | 0.1816 |
Mycobacterium ulcerans | oxidoreductase | 0.0045 | 0.0045 | 0.0007 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0225 | 0.0929 | 0.0894 |
Schistosoma mansoni | Lysine-specific histone demethylase 1 | 0.0045 | 0.0045 | 0.0717 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.008 | 0.0215 | 1 |
Brugia malayi | SWIRM domain containing protein | 0.0045 | 0.0045 | 0.1816 |
Brugia malayi | Matrixin family protein | 0.0087 | 0.025 | 1 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.0792 | 0.3707 | 1 |
Mycobacterium tuberculosis | Possible oxidoreductase | 0.0045 | 0.0045 | 0.0007 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0641 | 0.2969 | 0.2942 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 0.045 mg kg-1 | Analgesic activity at 1 min following injection at 1 mg/kg into the lateral tail vein of the rat (55 degree centigrade hot plate assay) | ChEMBL. | 1847432 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.