Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0051 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0093 | 0.377 | 0.245 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0103 | 0.4666 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0051 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0051 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0103 | 0.4666 | 0.3536 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0051 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0051 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0051 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0142 | 0.8068 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0163 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
logP (ADMET) | = 0.36 | Partition coefficient (logP) | ChEMBL. | 1995911 |
Optimal dose (functional) | = 147 uM kg-1 | Optimal dose of the compound evaluated for antitumor activity against P388 murine leukemia cells in female DBA/2 mice. | ChEMBL. | 1995911 |
T/C (functional) | = 199 % | Median survival time of treated mice with respect to untreated controls. | ChEMBL. | 1995911 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.