Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Dihydrofolate reductase | 0.021 | 0.9883 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0211 | 1 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.021 | 0.9883 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.021 | 0.9883 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.021 | 0.9883 | 1 |
Chlamydia trachomatis | dihydrofolate reductase | 0.021 | 0.9883 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.021 | 0.9883 | 1 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.021 | 0.9883 | 1 |
Onchocerca volvulus | 0.0105 | 0 | 0.5 | |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0211 | 1 | 0.5 |
Echinococcus granulosus | dihydrofolate reductase | 0.021 | 0.9883 | 1 |
Brugia malayi | dihydrofolate reductase family protein | 0.021 | 0.9883 | 1 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0211 | 1 | 0.5 |
Schistosoma mansoni | dihydrofolate reductase | 0.021 | 0.9883 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0211 | 1 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0211 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K ass (binding) | = 2500000 l M-1 | Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. | ChEMBL. | 10715154 |
K ass (binding) | = 2500000 l M-1 | Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. | ChEMBL. | 10715154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.