Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.0661 | 0.4166 | 0.5 |
Schistosoma mansoni | carbonic anhydrase | 0.0661 | 0.4166 | 0.5165 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.1038 | 0.8066 | 0.5 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1038 | 0.8066 | 0.5 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.094 | 0.7049 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1038 | 0.8066 | 1 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.1038 | 0.8066 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.0007 | 0.0009 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1226 | 1 | 0.5 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.1038 | 0.8066 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.1038 | 0.8066 | 1 |
Echinococcus granulosus | carbonic anhydrase II | 0.1038 | 0.8066 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0257 | 0 | 0.5 |
Echinococcus multilocularis | survival motor neuron protein 1 | 0.0258 | 0.0007 | 0.0009 |
Echinococcus granulosus | survival motor neuron protein 1 | 0.0258 | 0.0007 | 0.0009 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.1038 | 0.8066 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1226 | 1 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1038 | 0.8066 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.1038 | 0.8066 | 1 |
Brugia malayi | hypothetical protein | 0.0258 | 0.0007 | 0.0009 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.0375 | 0.1214 | 0.1365 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.0661 | 0.4166 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1038 | 0.8066 | 1 |
Plasmodium falciparum | carbonic anhydrase | 0.0257 | 0 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase II | 0.1038 | 0.8066 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Score (functional) | = 55 | Inhibition of the 6-OHDA-induced Hypokinesia in rat, at 50 mg/Kg sc, expressed as cumulative ambulation score | ChEMBL. | 6429333 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.