Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | chymase 1, mast cell | Starlite/ChEMBL | References |
Homo sapiens | chymotrypsin C (caldecrin) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | chymotrypsin C (caldecrin) | 268 aa | 236 aa | 21.6 % |
Brugia malayi | Trypsin family protein | chymase 1, mast cell | 247 aa | 295 aa | 24.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | IMP dehydrogenase 1 | 0.1245 | 1 | 1 |
Echinococcus multilocularis | inosine 5' monophosphate dehydrogenase 2 | 0.1245 | 1 | 1 |
Echinococcus granulosus | inosine 5' monophosphate dehydrogenase 2 | 0.1245 | 1 | 1 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.1245 | 1 | 0.5 |
Loa Loa (eye worm) | GMP reductase | 0.0518 | 0.2322 | 0.1723 |
Leishmania major | guanosine monophosphate reductase | 0.1245 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.1245 | 1 | 0.5 |
Leishmania major | inosine-5-monophosphate dehydrogenase | 0.1245 | 1 | 0.5 |
Trypanosoma brucei | GMP reductase | 0.1245 | 1 | 0.5 |
Mycobacterium ulcerans | inosine 5-monophosphate dehydrogenase | 0.1171 | 0.922 | 0.8869 |
Schistosoma mansoni | integrin alpha | 0.0664 | 0.3862 | 0.3862 |
Mycobacterium tuberculosis | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase | 0.1245 | 1 | 1 |
Mycobacterium ulcerans | inosine 5'-monophosphate dehydrogenase | 0.1245 | 1 | 1 |
Loa Loa (eye worm) | integrin alpha pat-2 | 0.1023 | 0.7653 | 0.747 |
Plasmodium falciparum | inosine-5'-monophosphate dehydrogenase | 0.1171 | 0.922 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0518 | 0.2322 | 0.021 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.0664 | 0.3862 | 0.2174 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0395 | 0.1032 | 0.1032 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) | 0.1245 | 1 | 1 |
Toxoplasma gondii | IMP dehydrogenas | 0.1245 | 1 | 0.5 |
Onchocerca volvulus | Putative GMP reductase | 0.0518 | 0.2322 | 0.5 |
Brugia malayi | inosine-5'-monophosphate dehydrogenase | 0.0518 | 0.2322 | 0.021 |
Plasmodium vivax | inosine-5'-monophosphate dehydrogenase, putative | 0.1171 | 0.922 | 0.5 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.1245 | 1 | 0.5 |
Trypanosoma cruzi | GMP reductase | 0.1245 | 1 | 0.5 |
Brugia malayi | GMP reductase | 0.0518 | 0.2322 | 0.021 |
Loa Loa (eye worm) | hypothetical protein | 0.0521 | 0.2358 | 0.1761 |
Schistosoma mansoni | inosine-5-monophosphate dehydrogenase | 0.1245 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | IMP dehydrogenase | 0.1245 | 1 | 0.5 |
Mycobacterium leprae | Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena | 0.0654 | 0.376 | 0.0954 |
Trypanosoma cruzi | inosine-5'-monophosphate dehydrogenase, putative | 0.1245 | 1 | 0.5 |
Echinococcus granulosus | integrin alpha 3 | 0.0509 | 0.2228 | 0.2228 |
Loa Loa (eye worm) | hypothetical protein | 0.0502 | 0.2157 | 0.1545 |
Trypanosoma brucei | inosine-5'-monophosphate dehydrogenase | 0.1245 | 1 | 0.5 |
Echinococcus multilocularis | integrin alpha 3 | 0.0509 | 0.2228 | 0.2228 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 5.6 nM | Compound was evaluated for inhibitory activity against human heart chymase (HHC) | ChEMBL. | 9871512 |
Ki (binding) | = 5.6 nM | Compound was evaluated for inhibitory activity against human heart chymase (HHC) | ChEMBL. | 9871512 |
Ki (binding) | = 364 nM | Compound was evaluated for inhibitory activity against Bovine Chymotrypsinogen | ChEMBL. | 9871512 |
Ki (binding) | = 364 nM | Compound was evaluated for inhibitory activity against Bovine Chymotrypsinogen | ChEMBL. | 9871512 |
Ratio (binding) | = 65 | Selectivity ratio of Bovine chymotrypsin (BCT-Ki) to human heart chymase (HHC-Ki) | ChEMBL. | 9871512 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.