Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Schistosoma mansoni | integrin beta subunit | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-3 precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus granulosus | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | Integrin beta-PS precursor, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Schistosoma japonicum | ko:K06464 integrin beta 2, putative | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Loa Loa (eye worm) | integrin beta-2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Echinococcus multilocularis | integrin beta 2 | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Brugia malayi | Integrin beta pat-3 precursor | Get druggable targets OG5_127959 | All targets in OG5_127959 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | conserved hypothetical protein | 0.1511 | 0.4836 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.1371 | 0.4308 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1371 | 0.4308 | 0.3955 |
Echinococcus multilocularis | carbonic anhydrase II | 0.2887 | 1 | 1 |
Entamoeba histolytica | carbonic anhydrase, putative | 0.1571 | 0.5062 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.1371 | 0.4308 | 0.4183 |
Toxoplasma gondii | hypothetical protein | 0.1371 | 0.4308 | 0.5 |
Mycobacterium leprae | CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) | 0.1571 | 0.5062 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.1371 | 0.4308 | 0.4308 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.1371 | 0.4308 | 0.3955 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase CanB | 0.1 | 0.2917 | 1 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1371 | 0.4308 | 0.3955 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2887 | 1 | 0.5 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1371 | 0.4308 | 0.3955 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1371 | 0.4308 | 0.4308 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1371 | 0.4308 | 0.4308 |
Echinococcus granulosus | carbonic anhydrase II | 0.2887 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.2887 | 1 | 0.5 |
Echinococcus multilocularis | carbonic anhydrase | 0.1371 | 0.4308 | 0.4183 |
Loa Loa (eye worm) | hypothetical protein | 0.1371 | 0.4308 | 0.3955 |
Schistosoma mansoni | carbonic anhydrase | 0.1371 | 0.4308 | 0.4308 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1371 | 0.4308 | 0.3955 |
Echinococcus granulosus | carbonic anhydrase | 0.1371 | 0.4308 | 0.4183 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.2887 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2887 | 1 | 1 |
Echinococcus granulosus | carbonic anhydrase | 0.1371 | 0.4308 | 0.4183 |
Echinococcus multilocularis | carbonic anhydrase | 0.1371 | 0.4308 | 0.4183 |
Schistosoma mansoni | carbonic anhydrase-related | 0.1371 | 0.4308 | 0.4308 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.1371 | 0.4308 | 0.3955 |
Loa Loa (eye worm) | hypothetical protein | 0.1371 | 0.4308 | 0.3955 |
Echinococcus multilocularis | carbonic anhydrase | 0.1371 | 0.4308 | 0.4183 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.2887 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.2887 | 1 | 1 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.2887 | 1 | 1 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.2887 | 1 | 1 |
Mycobacterium ulcerans | carbonic anhydrase | 0.1571 | 0.5062 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.2887 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase | 0.1571 | 0.5062 | 0.5062 |
Trichomonas vaginalis | conserved hypothetical protein | 0.1511 | 0.4836 | 0.5 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.1371 | 0.4308 | 0.3955 |
Mycobacterium tuberculosis | Beta-carbonic anhydrase | 0.094 | 0.2691 | 0.8596 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 44 nM | Binding affinity towards VLA-4 (alpha4 beta1) receptor in human Jurkat cells using [125I]-VCAM-Ig as radioligand | ChEMBL. | 12617914 |
IC50 (binding) | = 44 nM | Binding affinity towards VLA-4 (alpha4 beta1) receptor in human Jurkat cells using [125I]-VCAM-Ig as radioligand | ChEMBL. | 12617914 |
Inhibition (binding) | = 19 % | Percent inhibition of [125I]-VCAM-Ig binding to human integrin alpha4-beta7 receptor of RPMI-8866 cells at 100 nM | ChEMBL. | 12617914 |
Inhibition (binding) | = 19 % | Percent inhibition of [125I]-VCAM-Ig binding to human integrin alpha4-beta7 receptor of RPMI-8866 cells at 100 nM | ChEMBL. | 12617914 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.