TDR Targets

Basic information

Technical information

TDR Targets ID: 29169
Name: N-(2H-tetrazol-5-yl)pyridine-3-carboxamide
MW: 190.162 | Formula: C7H6N6O
H donors: 2 H acceptors: 5 LogP: -0.43 Rotable bonds: 3
Rule of 5 violations (Lipinski): 1
SMILES: O=C(c1cccnc1)Nc1n[nH]nn1
InChi: 1S/C7H6N6O/c14-6(5-2-1-3-8-4-5)9-7-10-12-13-11-7/h1-4H,(H2,9,10,11,12,13,14)
InChiKey: BECASXACIZTTQU-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

N-(2H-tetrazol-5-yl)-3-pyridinecarboxamide
N-(2H-1,2,3,4-tetrazol-5-yl)pyridine-3-carboxamide
N-(2H-tetrazol-5-yl)nicotinamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Trypanosoma brucei	methionine aminopeptidase 2, putative	0.0747	0.9138	0.9137
Brugia malayi	larval opioid receptor	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	tubulin beta-1 chain	0.0808	1	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0623	0.7394	0.7394
Echinococcus granulosus	beta tubulin	0.0808	1	1
Leishmania major	beta tubulin	0.0808	1	1
Leishmania major	beta tubulin	0.0808	1	1
Brugia malayi	AKH receptor	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0808	1	1
Plasmodium falciparum	tubulin beta chain	0.0808	1	1
Echinococcus multilocularis	Tubulin beta 2C chain	0.0808	1	1
Brugia malayi	Serotonin receptor	0.0623	0.7394	0.7394
Echinococcus granulosus	Tubulin beta 2C chain	0.0808	1	1
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0623	0.7394	0.7394
Schistosoma mansoni	neuropeptide receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	neuropeptide f receptor 76f	0.0623	0.7394	0.7394
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0623	0.7394	0.7394
Echinococcus multilocularis	Tubulin beta 2C chain	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Brugia malayi	beta-tubulin, identical	0.0808	1	1
Loa Loa (eye worm)	tubulin beta chain	0.0808	1	1
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Schistosoma mansoni	opsin-like receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Entamoeba histolytica	tubulin family protein	0.0808	1	1
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0623	0.7394	0.7394
Loa Loa (eye worm)	initiation factor 2-associated protein	0.0747	0.9138	0.9138
Schistosoma mansoni	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	Dopamine receptor protein 1	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0623	0.7394	0.7394
Brugia malayi	G-protein coupled receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	histamine h1 receptor	0.0623	0.7394	0.7394
Brugia malayi	G protein-coupled receptor F59B2.13	0.0623	0.7394	0.7394
Schistosoma mansoni	neuropeptide F-like receptor	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	neuropeptide receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	myosin xvIII	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	Dopamine receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Trichomonas vaginalis	tubulin beta chain, putative	0.0808	1	1
Loa Loa (eye worm)	BEN-1 protein	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	methionyl aminopeptidase 2 (M24 family)	0.0747	0.9138	0.9138
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Schistosoma mansoni	opsin-like receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	BEN-1 protein	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus multilocularis	Tubulin beta 2C chain	0.0808	1	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0623	0.7394	0.7394
Brugia malayi	Serotonin receptor	0.0623	0.7394	0.7394
Echinococcus granulosus	tubulin beta 1 chain	0.0808	1	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0623	0.7394	0.7394
Schistosoma mansoni	tubulin subunit beta	0.0808	1	1
Schistosoma mansoni	amine GPCR	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	tubulin beta-2A chain	0.0808	1	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus granulosus	tubulin subunit beta	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Trichomonas vaginalis	tubulin alpha chain, putative	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	growth hormone secretagogue receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0623	0.7394	0.7394
Giardia lamblia	Beta tubulin	0.0808	1	1
Brugia malayi	GnHR receptor homolog	0.0623	0.7394	0.7394
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0623	0.7394	0.7394
Loa Loa (eye worm)	G-protein coupled receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0146	0.0653	0.0653
Schistosoma mansoni	biogenic amine receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0808	1	1
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	ORL1-like opioid receptor	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus granulosus	tubulin beta 4A class IVa	0.0808	1	1
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0623	0.7394	0.7394
Schistosoma mansoni	amine GPCR	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus granulosus	Tubulin beta 2C chain	0.0808	1	1
Schistosoma mansoni	biogenic amine receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	tubulin subunit beta	0.0808	1	1
Schistosoma mansoni	opsin-like receptor	0.0623	0.7394	0.7394
Echinococcus multilocularis	Tubulin beta 2C chain	0.0808	1	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0623	0.7394	0.7394
Schistosoma mansoni	biogenic amine receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0623	0.7394	0.7394
Echinococcus multilocularis	tubulin subunit beta	0.0808	1	1
Echinococcus granulosus	Tubulin beta 2C chain	0.0808	1	1
Loa Loa (eye worm)	G-protein coupled receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	hypothetical protein	0.0101	0.0014	0.0014
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0623	0.7394	0.7394
Brugia malayi	putative neuropeptide receptor	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Giardia lamblia	Beta tubulin	0.0808	1	1
Echinococcus multilocularis	methionyl aminopeptidase 2	0.0747	0.9138	0.6693
Schistosoma mansoni	neuropeptide receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	tubulin subunit beta	0.0808	1	1
Schistosoma mansoni	adenoreceptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Trichomonas vaginalis	tubulin, putative	0.0808	1	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0146	0.0653	0.0653
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0623	0.7394	0.7394
Giardia lamblia	Beta tubulin	0.0808	1	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0623	0.7394	0.7394
Echinococcus granulosus	beta tubulin	0.0808	1	1
Brugia malayi	Melatonin receptor type 1A	0.0623	0.7394	0.7394
Trypanosoma brucei	beta tubulin	0.0808	1	1
Toxoplasma gondii	beta tubulin	0.0808	1	1
Brugia malayi	putative neuropeptide receptor NPR1	0.0623	0.7394	0.7394
Loa Loa (eye worm)	neuropeptide F receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	hypothetical protein	0.0623	0.7394	0.7394
Trypanosoma brucei	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus multilocularis	beta tubulin	0.0808	1	1
Schistosoma mansoni	tubulin subunit beta	0.0808	1	1
Plasmodium vivax	tubulin beta chain, putative	0.0808	1	1
Brugia malayi	G protein-coupled receptor	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Echinococcus multilocularis	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0623	0.7394	0.7394
Schistosoma mansoni	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Entamoeba histolytica	tubulin family protein	0.0808	1	1
Leishmania major	beta tubulin	0.0808	1	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0623	0.7394	0.7394
Brugia malayi	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Toxoplasma gondii	beta-tubulin, putative	0.0808	1	1
Trichomonas vaginalis	tubulin gamma chain, putative	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Echinococcus granulosus	methionyl aminopeptidase 2	0.0747	0.9138	0.6693
Onchocerca volvulus	Methionine aminopeptidase 2 homolog	0.0747	0.9138	1
Trypanosoma brucei	beta tubulin	0.0808	1	1
Trichomonas vaginalis	tubulin epsilon chain, putative	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	initiation factor 2-associated protein.	0.0747	0.9138	0.9138
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0623	0.7394	0.7394
Schistosoma mansoni	tubulin subunit beta	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus granulosus	Tubulin beta 2C chain	0.0808	1	1
Schistosoma mansoni	tubulin subunit beta	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Echinococcus multilocularis	Tubulin beta 2C chain	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0146	0.0653	0.0653
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Trypanosoma cruzi	beta tubulin, putative	0.0808	1	1
Brugia malayi	RE15519p	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	neuropeptide receptor	0.0623	0.7394	0.7394
Brugia malayi	sulfakinin receptor protein	0.0623	0.7394	0.7394
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0623	0.7394	0.7394
Brugia malayi	neuropeptide F receptor	0.0623	0.7394	0.7394
Toxoplasma gondii	beta-1 tubulin, putative	0.0808	1	1
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0146	0.0653	0.0653
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Schistosoma mansoni	amine GPCR	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	follicle stimulating hormone receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	beta-tubulin	0.0808	1	1
Schistosoma mansoni	amine GPCR	0.0623	0.7394	0.7394
Echinococcus multilocularis	tubulin beta 1 chain	0.0808	1	1
Echinococcus multilocularis	tubulin, beta 4A class IVa	0.0808	1	1
Loa Loa (eye worm)	tubulin beta-4 chain	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	TYRA-2 protein	0.0623	0.7394	0.7394
Leishmania major	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	neuropeptide F receptor	0.0623	0.7394	0.7394
Trypanosoma brucei	metallo-peptidase, Clan MG, Family M24	0.0747	0.9138	0.9137
Brugia malayi	G-protein coupled receptor	0.0623	0.7394	0.7394
Trypanosoma brucei	beta tubulin	0.0808	1	1
Loa Loa (eye worm)	hypothetical protein	0.0623	0.7394	0.7394
Brugia malayi	Dopamine receptor protein 2	0.0623	0.7394	0.7394
Schistosoma mansoni	amine GPCR	0.0623	0.7394	0.7394
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0623	0.7394	0.7394

Activities

Activity type	Activity value	Assay description	Source	Reference
Inhibition (functional)	= 3 %	Inhibition of passive cutaneous anaphylaxis following 10 mg/kg p.o. administration.	ChEMBL.	6229634
Inhibition (functional)	= 4 %	Inhibition of passive cutaneous anaphylaxis following 3 mg/kg p.o. administration.	ChEMBL.	6229634
Inhibition (functional)	= 18 %	Inhibition of passive cutaneous anaphylaxis following 30 mg/kg p.o. administration.	ChEMBL.	6229634

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL281154
PubChem: 4069765

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 29169