Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0219 | 0.0064 | 0.0579 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0219 | 0.0064 | 0.1537 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.4367 | 0.3735 | 0.5 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0399 | 0.0223 | 1 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.4367 | 0.3735 | 0.5 |
Onchocerca volvulus | 0.0255 | 0.0095 | 0.3431 | |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0654 | 0.0448 | 1 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 1.1445 | 1 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0399 | 0.0223 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0654 | 0.0448 | 1 |
Trypanosoma brucei | Peptide deformylase 2 | 0.4367 | 0.3735 | 0.5 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0256 | 0.0096 | 0.214 |
Schistosoma mansoni | hypothetical protein | 0.0255 | 0.0095 | 0.414 |
Echinococcus granulosus | adam 17 protease | 0.0448 | 0.0266 | 0.5938 |
Echinococcus multilocularis | adam 17 protease | 0.0408 | 0.023 | 0.5136 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0192 | 0.004 | 0.0891 |
Plasmodium vivax | peptide deformylase, putative | 1.1445 | 1 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.018 | 0.0029 | 0.1252 |
Loa Loa (eye worm) | matrixin family protein | 0.0399 | 0.0223 | 0.3238 |
Brugia malayi | Matrixin family protein | 0.0435 | 0.0255 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0435 | 0.0255 | 0.377 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0192 | 0.004 | 0.1735 |
Plasmodium falciparum | peptide deformylase | 1.1445 | 1 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0255 | 0.0095 | 0.2947 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.4367 | 0.3735 | 0.5 |
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.0408 | 0.023 | 1 |
Mycobacterium tuberculosis | Possible exported protein | 0.0489 | 0.0303 | 0.0241 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0192 | 0.004 | 0.0493 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 1.1445 | 1 | 0.5 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0192 | 0.004 | 0.0891 |
Loa Loa (eye worm) | hypothetical protein | 0.0856 | 0.0628 | 1 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0256 | 0.0096 | 0.214 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.4367 | 0.3735 | 0.5 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.4367 | 0.3735 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.4367 | 0.3735 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 1.1445 | 1 | 1 |
Treponema pallidum | polypeptide deformylase (def) | 1.1445 | 1 | 0.5 |
Mycobacterium ulcerans | peptide deformylase | 1.1445 | 1 | 1 |
Toxoplasma gondii | hypothetical protein | 1.1445 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Max fall in blood pressure (functional) | = 33 | Tested for antihypertensive activity expressed as max fall in BP in spontaneously hypertensive rats (SHR), at the dose of 10.0 mg/kg | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.