Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | ADAM17 peptidase (M12 family) | 0.042 | 0.0285 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0226 | 0.0085 | 0.0038 |
Mycobacterium ulcerans | peptide deformylase | 0.9875 | 1 | 1 |
Brugia malayi | metalloprotease disintegrin 16 with thrombospondin type I motif | 0.0198 | 0.0057 | 0.0492 |
Brugia malayi | Matrixin family protein | 0.0449 | 0.0314 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0411 | 0.0276 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0047 | 0.0622 |
Loa Loa (eye worm) | matrixin family protein | 0.0449 | 0.0314 | 0.413 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0047 | 0.0622 |
Plasmodium falciparum | peptide deformylase | 0.9875 | 1 | 0.5 |
Echinococcus multilocularis | a disintegrin and metalloproteinase with | 0.0198 | 0.0057 | 0.0197 |
Brugia malayi | Hemopexin family protein | 0.0263 | 0.0123 | 0.2947 |
Echinococcus multilocularis | adam 17 protease | 0.042 | 0.0285 | 0.4765 |
Trypanosoma brucei | Polypeptide deformylase 1 | 0.3768 | 0.3725 | 0.5 |
Schistosoma mansoni | family M13 unassigned peptidase (M13 family) | 0.0189 | 0.0047 | 0.1641 |
Loa Loa (eye worm) | hypothetical protein | 0.0226 | 0.0085 | 0.1122 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0674 | 0.0546 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0189 | 0.0047 | 0.0622 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0226 | 0.0085 | 0.1537 |
Brugia malayi | Peptidase family M13 containing protein | 0.0189 | 0.0047 | 0.0128 |
Toxoplasma gondii | hypothetical protein | 0.9875 | 1 | 1 |
Mycobacterium tuberculosis | Possible exported protein | 0.1521 | 0.1416 | 0.1375 |
Echinococcus granulosus | a disintegrin and metalloproteinase with | 0.0198 | 0.0057 | 0.0197 |
Echinococcus granulosus | Blood coagulation inhibitor Disintegrin | 0.0264 | 0.0124 | 0.1541 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3768 | 0.3725 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3768 | 0.3725 | 0.5 |
Trypanosoma cruzi | Peptide deformylase 2, putative | 0.3768 | 0.3725 | 0.5 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0186 | 0.0044 | 0.152 |
Treponema pallidum | polypeptide deformylase (def) | 0.9875 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable polypeptide deformylase Def (PDF) (formylmethionine deformylase) | 0.9875 | 1 | 1 |
Plasmodium vivax | peptide deformylase, putative | 0.9875 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE POLYPEPTIDE DEFORMYLASE DEF (PDF) (FORMYLMETHIONINE DEFORMYLASE) | 0.9875 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0044 | 0.0576 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0226 | 0.0085 | 0.0038 |
Mycobacterium ulcerans | hydrolase | 0.0226 | 0.0085 | 0.0038 |
Leishmania major | polypeptide deformylase-like protein, putative | 0.3768 | 0.3725 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0411 | 0.0276 | 1 |
Trypanosoma cruzi | polypeptide deformylase-like protein, putative | 0.3768 | 0.3725 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0186 | 0.0044 | 0.0576 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0044 | 0.0576 |
Onchocerca volvulus | 0.0263 | 0.0123 | 0.3431 | |
Loa Loa (eye worm) | hypothetical protein | 0.0883 | 0.0761 | 1 |
Wolbachia endosymbiont of Brugia malayi | peptide deformylase | 0.9875 | 1 | 0.5 |
Loa Loa (eye worm) | matrixin family protein | 0.0411 | 0.0276 | 0.3628 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0674 | 0.0546 | 1 |
Brugia malayi | Hypothetical zinc metalloproteinase T16A9.4 | 0.0189 | 0.0047 | 0.0128 |
Trypanosoma brucei | Peptide deformylase 2 | 0.3768 | 0.3725 | 0.5 |
Echinococcus multilocularis | Blood coagulation inhibitor, Disintegrin | 0.0264 | 0.0124 | 0.1541 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.0123 | 0.432 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 0.0044 | 0.0576 |
Echinococcus granulosus | adam 17 protease | 0.0462 | 0.0328 | 0.5627 |
Schistosoma mansoni | ADAMTS5 peptidase (M12 family) | 0.0198 | 0.0057 | 0.1987 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.