Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | nuclear hormone receptor | 0.0864 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-67 | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | nuclear hormone receptor | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0864 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 1 group D | 0.0457 | 0.5224 | 0.5224 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0864 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0864 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0864 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 4 group A | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0864 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0864 | 1 | 1 |
Brugia malayi | conserved hypotetical protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0864 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0864 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0864 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0864 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0864 | 1 | 1 |
Echinococcus granulosus | thyroid hormone receptor alpha | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0864 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0864 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0457 | 0.5224 | 0.5224 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0864 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0457 | 0.5224 | 0.5224 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0864 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member odr-7 | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0864 | 1 | 1 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0864 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Brugia malayi | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Schistosoma mansoni | nuclear receptor | 0.0408 | 0.4651 | 0.4651 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0864 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | nuclear hormone receptor-like 1 | 0.0457 | 0.5224 | 0.5224 |
Schistosoma mansoni | nuclear receptor | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0864 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0864 | 1 | 1 |
Schistosoma mansoni | zinc finger protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0864 | 1 | 1 |
Schistosoma mansoni | nuclear receptor nhr-48 | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0457 | 0.5224 | 0.5224 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0037 | 0.0305 | 0.0305 |
Brugia malayi | orphan nuclear receptor NR2E1 | 0.0408 | 0.4651 | 0.4651 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0864 | 1 | 1 |
Echinococcus granulosus | FTZ F1 alpha | 0.0864 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0864 | 1 | 1 |
Brugia malayi | nuclear hormone receptor | 0.0408 | 0.4651 | 0.4651 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0864 | 1 | 1 |
Brugia malayi | nuclear hormone receptor family member nhr-6 | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | hepatocyte nuclear factor 4-alpha (hnf-4-alpha) | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor subfamily 1 group D | 0.0457 | 0.5224 | 0.5224 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0864 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0864 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0457 | 0.5224 | 0.5224 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | tailless protein | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0864 | 1 | 1 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0037 | 0.0305 | 0.0305 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0864 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0277 | 0.5 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0864 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0864 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0034 | 0.0277 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Echinococcus multilocularis | retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Brugia malayi | nuclear receptor RXR | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | steroid hormone receptor | 0.0864 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0864 | 1 | 1 |
Echinococcus granulosus | nuclear receptor subfamily 4 group A | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | ecdysone receptor | 0.0408 | 0.4651 | 0.4651 |
Echinococcus granulosus | nuclear receptor nhr 48 | 0.0408 | 0.4651 | 0.4651 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0408 | 0.4651 | 0.4651 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0864 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0864 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0345 | 0.0345 |
Schistosoma mansoni | voltage-gated potassium channel | 0.004 | 0.0345 | 0.0345 |
Echinococcus multilocularis | nuclear receptor nhr 48 | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | nuclear receptor subfamily 1, group D, member 1, putative | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0037 | 0.0305 | 0.0305 |
Brugia malayi | nuclear receptor NHR-88 | 0.0864 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor HR96 | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0864 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0864 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | coup transcription factor | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0037 | 0.0305 | 0.0305 |
Brugia malayi | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | nuclear hormone receptor | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | DR-78 | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | nuclear hormone receptor superfamily protein-related | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Nuclear hormone receptor E75 | 0.0408 | 0.4651 | 0.4651 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0864 | 1 | 1 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0864 | 1 | 1 |
Onchocerca volvulus | 0.0864 | 1 | 1 | |
Schistosoma mansoni | thyroid hormone receptor | 0.0864 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | nuclear receptor NHR-67 | 0.0408 | 0.4651 | 0.4651 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0248 | 0.0248 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0864 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0457 | 0.5224 | 0.5224 |
Echinococcus granulosus | Nuclear hormone receptor HR96 | 0.0408 | 0.4651 | 0.4651 |
Schistosoma mansoni | ecdysone-induced protein 78c (dr-78) | 0.0457 | 0.5224 | 0.5224 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0864 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 3.54 | H1-Histamine receptor agonism on Guinea pig aorta was evaluated (SEM 0.03-0.18) | ChEMBL. | 7731015 |
Intrinsic activity (functional) | = 0.51 | H1-Histamine receptor agonism on Guinea pig aorta was evaluated as Intrinsic activity given as 1.0 with respect to histamine(paired 't'test;p>0.05) | ChEMBL. | 7731015 |
Intrinsic activity (functional) | = 0.76 | H1-Histamine receptor agonism on guinea pig ileum as intrinsic activity given as 1.0 with respect to histamine (paired 't'test; p>0.05). | ChEMBL. | 7731015 |
Log EC50 (functional) | = 3.54 | H1-Histamine receptor agonism on Guinea pig aorta was evaluated (SEM 0.03-0.18) | ChEMBL. | 7731015 |
pD2 (functional) | = 4.88 | Contractile effect on isolated guinea pig ileal segments by H1 (histamine) receptor agonism. | ChEMBL. | 7731015 |
pKb (functional) | 0 | Contractile effects of compound on the guinea pig aorta as a measure of histamine H1 receptor agonism; f - effect could be antagonized with 1 pM mepyramine addedto the bath solution when a plateau was reached. | ChEMBL. | 7731015 |
pKb (functional) | = 8.81 | The H1 receptor-mediated nature of the ileum contractionhas been verified by competition experiments with the H1 receptor antagonist mepyramine | ChEMBL. | 7731015 |
Relative activity (functional) | = 0.4 % | Contractile effect on isolated guinea pig aorta is a measure of H1 (histamine) receptor agonistic activity relative to histamine | ChEMBL. | 7731015 |
Relative activity (functional) | = 0.4 % | Contractile effect on isolated guinea pig aorta is a measure of H1 (histamine) receptor agonistic activity relative to histamine | ChEMBL. | 7731015 |
Relative activity (functional) | = 2 % | Contractile effect on isolated guinea pig ileal segments is a measure of H1 (histamine) receptor agonistic activity relative to histamine. | ChEMBL. | 7731015 |
Relative activity (functional) | = 2 % | Contractile effect on isolated guinea pig ileal segments is a measure of H1 (histamine) receptor agonistic activity relative to histamine. | ChEMBL. | 7731015 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.