Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.029 | 0.0472 | 0.1536 |
Brugia malayi | Cathepsin L-like precursor | 0.0425 | 0.2028 | 0.2008 |
Loa Loa (eye worm) | papain family cysteine protease containing protein | 0.0425 | 0.2028 | 0.1633 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0425 | 0.2028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0516 | 0.3074 | 0.3691 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0672 | 0.4861 | 0.4847 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trypanosoma cruzi | major cysteine proteinase, putative | 0.0362 | 0.1302 | 0.1279 |
Loa Loa (eye worm) | cysteine protease | 0.0425 | 0.2028 | 0.1633 |
Entamoeba histolytica | cysteine proteinase, putative | 0.0425 | 0.2028 | 1 |
Brugia malayi | cathepsin L-like precursor | 0.029 | 0.0472 | 0.0447 |
Brugia malayi | Cathepsin L-like precursor | 0.029 | 0.0472 | 0.0447 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0425 | 0.2028 | 0.2008 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0516 | 0.3074 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Onchocerca volvulus | Cathepsin L homolog | 0.0425 | 0.2028 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0425 | 0.2028 | 0.2008 |
Leishmania major | cathepsin L-like protease | 0.0672 | 0.4861 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.029 | 0.0472 | 0.1536 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0251 | 0.0026 | 0.0084 |
Loa Loa (eye worm) | fibroinase | 0.0425 | 0.2028 | 0.1633 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Giardia lamblia | Cathepsin B precursor | 0.0516 | 0.3074 | 1 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0251 | 0.0026 | 0.0084 |
Plasmodium vivax | vivapain-2 | 0.0425 | 0.2028 | 1 |
Plasmodium vivax | vivapain-2 | 0.0425 | 0.2028 | 1 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Plasmodium falciparum | dipeptidyl aminopeptidase 2 | 0.033 | 0.0936 | 0.4544 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.0425 | 0.2028 | 1 |
Echinococcus multilocularis | cysteine protease | 0.0425 | 0.2028 | 0.2008 |
Toxoplasma gondii | cathepsin B | 0.0516 | 0.3074 | 1 |
Loa Loa (eye worm) | ctsf protein | 0.0425 | 0.2028 | 0.1633 |
Echinococcus granulosus | cathepsin L cysteine proteinase | 0.0425 | 0.2028 | 0.2008 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1119 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 | |
Giardia lamblia | Cathepsin B precursor | 0.0516 | 0.3074 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0516 | 0.3074 | 0.3056 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0516 | 0.3074 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0672 | 0.4861 | 0.4847 |
Brugia malayi | Cathepsin L-like precursor | 0.0425 | 0.2028 | 0.2008 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0425 | 0.2028 | 0.2008 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Trypanosoma cruzi | cysteine peptidase, putative | 0.0672 | 0.4861 | 0.4847 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0425 | 0.2028 | 0.2008 |
Entamoeba histolytica | cysteine proteinase, putative | 0.029 | 0.0472 | 0.2228 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L or K-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Plasmodium vivax | dipeptidyl aminopeptidase 2, putative | 0.033 | 0.0936 | 0.4544 |
Leishmania major | cathepsin L-like protease | 0.0672 | 0.4861 | 1 |
Brugia malayi | Cathepsin L-like precursor | 0.0425 | 0.2028 | 0.2008 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Plasmodium vivax | dipeptidyl aminopeptidase 1, putative | 0.033 | 0.0936 | 0.4544 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Echinococcus granulosus | cathepsin b | 0.1119 | 1 | 1 |
Entamoeba histolytica | cysteine protease, putative | 0.0425 | 0.2028 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.0425 | 0.2028 | 0.2008 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0516 | 0.3074 | 0.6304 |
Brugia malayi | Cathepsin L-like precursor | 0.029 | 0.0472 | 0.0447 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0425 | 0.2028 | 0.2008 |
Echinococcus multilocularis | cathepsin b | 0.1119 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1119 | 1 | 1 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Echinococcus multilocularis | cathepsin b | 0.1119 | 1 | 1 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.1119 | 1 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1119 | 1 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.1119 | 1 | 1 |
Echinococcus multilocularis | cathepsin l cysteine peptidase | 0.0425 | 0.2028 | 0.2008 |
Loa Loa (eye worm) | Papain cysteine protease/cathepsin propeptide inhibitor-containing protein | 0.0425 | 0.2028 | 0.1633 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.0425 | 0.2028 | 1 |
Echinococcus granulosus | cathepsin b | 0.1119 | 1 | 1 |
Echinococcus multilocularis | cathepsin L cysteine protease | 0.0425 | 0.2028 | 0.2008 |
Echinococcus granulosus | cathepsin l1 | 0.029 | 0.0472 | 0.0447 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Loa Loa (eye worm) | cathepsin B | 0.0516 | 0.3074 | 0.273 |
Trypanosoma cruzi | cruzipain precursor, putative | 0.0672 | 0.4861 | 0.4847 |
Schistosoma mansoni | cathepsin F (C01 family) | 0.029 | 0.0472 | 0.0447 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0516 | 0.3074 | 0.3056 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.1119 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.2028 | 0.1633 |
Echinococcus granulosus | cathepsin l cysteine peptidase | 0.0425 | 0.2028 | 0.2008 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Toxoplasma gondii | cathepsin CPL | 0.0425 | 0.2028 | 0.511 |
Echinococcus granulosus | cathepsin l1 | 0.0425 | 0.2028 | 0.2008 |
Trypanosoma cruzi | cysteine peptidase, clan CA, family C1, cathepsin L-like, putative | 0.0536 | 0.3304 | 0.3287 |
Brugia malayi | Cathepsin L-like precursor | 0.0425 | 0.2028 | 0.2008 |
Schistosoma mansoni | dipeptidyl-peptidase I (C01 family) | 0.033 | 0.0936 | 0.0912 |
Onchocerca volvulus | Cathepsin F homolog | 0.0425 | 0.2028 | 1 |
Trypanosoma brucei | cysteine peptidase, Clan CA, family C1, Cathepsin L-like | 0.0672 | 0.4861 | 1 |
Brugia malayi | Cathepsin L-like cysteine proteinase | 0.029 | 0.0472 | 0.0447 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Brugia malayi | Papain family cysteine protease containing protein | 0.0425 | 0.2028 | 0.2008 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.0425 | 0.2028 | 1 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 | |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Echinococcus multilocularis | cysteine protease | 0.0425 | 0.2028 | 0.2008 |
Leishmania major | cathepsin L-like protease | 0.0672 | 0.4861 | 1 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Onchocerca volvulus | Cathepsin L homolog | 0.0425 | 0.2028 | 1 |
Plasmodium falciparum | dipeptidyl aminopeptidase 1 | 0.033 | 0.0936 | 0.4544 |
Brugia malayi | Cathepsin L-like precursor | 0.0425 | 0.2028 | 0.2008 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin L-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Trichomonas vaginalis | Clan CA, family C1, papain-like cysteine peptidase | 0.0425 | 0.2028 | 0.6599 |
Onchocerca volvulus | 0.0425 | 0.2028 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 39 ug kg-1 | In vivo beta adrenergic receptor blocking potency was determined by inhibition of tachycardia produced by isoproterenol (0.2 mg/kg iv) in cat preparation | ChEMBL. | 6128420 |
Inhibition (functional) | = 0 % | In vivo beta adrenergic receptor blocking potency was determined by inhibition of depressor response produced by isoproterenol (0.2 mg/kg iv) in cat preparation | ChEMBL. | 6128420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.