TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 392.492 | Formula: C22H21FN4S
H donors: 1 H acceptors: 0 LogP: 4.22 Rotable bonds: 2
Rule of 5 violations (Lipinski): 1
SMILES: CN1CCN(CC1)C1=Nc2cc(F)ccc2Nc2c1cc(s2)c1ccccc1
InChi: 1S/C22H21FN4S/c1-26-9-11-27(12-10-26)21-17-14-20(15-5-3-2-4-6-15)28-22(17)25-18-8-7-16(23)13-19(18)24-21/h2-8,13-14,25H,9-12H2,1H3
InChiKey: ODLKKPTWQGGRQI-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Loa Loa (eye worm)	hypothetical protein	0.0047	0.0236	0.2481
Echinococcus granulosus	neuropeptide receptor A26	0.0045	0.0217	0.034
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0217	0.0116
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.0217	0.0116
Echinococcus granulosus	nmda type glutamate receptor	0.0258	0.2665	0.7592
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0045	0.0217	0.2282
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0217	0.0002
Echinococcus granulosus	hypothetical protein	0.0045	0.0217	0.034
Brugia malayi	RE15519p	0.0045	0.0217	0.2282
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0045	0.0217	0.0002
Echinococcus multilocularis	sex peptide receptor	0.0045	0.0217	0.0116
Echinococcus multilocularis	dro:myosuppressin receptor	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	putative neuropeptide receptor	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.0217	0.034
Brugia malayi	follicle stimulating hormone receptor	0.0045	0.0217	0.2282
Echinococcus granulosus	neuropeptide receptor	0.0045	0.0217	0.034
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0217	0.0002
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	adenoreceptor	0.0045	0.0217	0.0002
Echinococcus granulosus	neuropeptide receptor	0.0045	0.0217	0.034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Echinococcus multilocularis	serotonin receptor	0.0045	0.0217	0.0116
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0045	0.0217	0.0002
Onchocerca volvulus		0.0045	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0109	0.095	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Echinococcus multilocularis	G protein coupled receptor 139	0.0045	0.0217	0.0116
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0045	0.0217	0.0002
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0	0.5
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein (hisJ)	0.0059	0.0382	0.5
Brugia malayi	Dopamine receptor protein 1	0.0045	0.0217	0.2282
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.0217	0.0116
Echinococcus granulosus	neuropeptide FF receptor 2	0.0045	0.0217	0.034
Chlamydia trachomatis	glutamine binding protein	0.0059	0.0382	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Schistosoma mansoni	opsin-like receptor	0.0045	0.0217	0.0002
Echinococcus multilocularis	neuropeptide s receptor	0.0045	0.0217	0.0116
Echinococcus multilocularis	Niemann Pick C1 protein	0.0109	0.095	0.0856
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	G-protein coupled receptor	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	opsin-like receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0045	0.0217	0.0002
Brugia malayi	ORL1-like opioid receptor	0.0045	0.0217	0.2282
Chlamydia trachomatis	arginine ABC transporter substrate-binding protein ArtJ	0.0059	0.0382	0.5
Entamoeba histolytica	Niemann-Pick C1 protein, putative	0.0109	0.095	1
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0217	0.0116
Brugia malayi	G protein-coupled receptor	0.0045	0.0217	0.2282
Schistosoma mansoni	hypothetical protein	0.0045	0.0217	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Brugia malayi	CHE-14 protein	0.0047	0.0236	0.2481
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Onchocerca volvulus		0.0045	0.0217	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Treponema pallidum	amino acid ABC transporter, periplasmic binding protein	0.0059	0.0382	0.5
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0045	0.0217	0.0116
Schistosoma mansoni	eyes absent homolog	0.0097	0.0818	0.2217
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	glutamate receptor NMDA	0.0281	0.2932	1
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0217	0.034
Echinococcus multilocularis	nmda type glutamate receptor	0.0258	0.2665	0.259
Echinococcus multilocularis	allatostatin A receptor	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0045	0.0217	0.0116
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0217	0.2282
Schistosoma mansoni	hypothetical protein	0.0045	0.0217	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.0217	0.0002
Onchocerca volvulus		0.0045	0.0217	1
Schistosoma mansoni	growth hormone secretagogue receptor	0.0045	0.0217	0.0002
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.0217	0.0002
Echinococcus granulosus	sterol regulatory element binding protein	0.0047	0.0236	0.0396
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Schistosoma mansoni	histamine h1 receptor	0.0045	0.0217	0.0002
Echinococcus granulosus	fmrfamide receptor	0.0045	0.0217	0.034
Schistosoma mansoni	patched 1	0.0047	0.0236	0.0071
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Echinococcus granulosus	7TM GPCR rhodopsin	0.0045	0.0217	0.034
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Mycobacterium tuberculosis	Probable glutamine-binding lipoprotein GlnH (GLNBP)	0.0059	0.0382	1
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0045	0.0217	0.0116
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0045	0.0217	0.2282
Loa Loa (eye worm)	melatonin receptor type 1A	0.0045	0.0217	0.2282
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Schistosoma mansoni	neuropeptide f receptor 76f	0.0045	0.0217	0.0002
Brugia malayi	Melatonin receptor type 1A	0.0045	0.0217	0.2282
Schistosoma mansoni	hypothetical protein	0.0045	0.0217	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0818	0.8618
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Loa Loa (eye worm)	TYRA-2 protein	0.0045	0.0217	0.2282
Brugia malayi	Serotonin receptor	0.0045	0.0217	0.2282
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0	0.5
Echinococcus granulosus	dro:myosuppressin receptor	0.0045	0.0217	0.034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	Protein patched homolog 1	0.0047	0.0236	0.0396
Echinococcus multilocularis	fmrfamide receptor	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	neuropeptide receptor	0.0045	0.0217	0.0116
Brugia malayi	Serotonin receptor	0.0045	0.0217	0.2282
Echinococcus granulosus	glutamate receptor NMDA	0.0246	0.2529	0.7188
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.0217	0.034
Leishmania major	4-coumarate:coa ligase-like protein	0.0026	0	0.5
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0045	0.0217	0.0116
Echinococcus granulosus	neuropeptide Y receptor	0.0045	0.0217	0.034
Echinococcus multilocularis	Glutamate receptor, ionotropic kainate 3	0.0083	0.0648	0.0552
Echinococcus granulosus	G protein coupled receptor 139	0.0045	0.0217	0.034
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0045	0.0217	0.034
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0045	0.0217	0.034
Schistosoma mansoni	opsin-like receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	amine GPCR	0.0045	0.0217	0.0002
Schistosoma mansoni	niemann-pick C1 (NPC1)	0.011	0.0969	0.2772
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0045	0.0217	0.2282
Echinococcus multilocularis	Niemann Pick C1 protein	0.0155	0.1486	0.1399
Onchocerca volvulus		0.0045	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	amine GPCR	0.0045	0.0217	0.0002
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0045	0.0217	0.0116
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0217	0.034
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Onchocerca volvulus		0.0045	0.0217	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0217	0.0002
Onchocerca volvulus		0.0045	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0045	0.0217	0.034
Loa Loa (eye worm)	G-protein coupled receptor	0.0045	0.0217	0.2282
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0045	0.0217	0.034
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0045	0.0217	0.0002
Echinococcus multilocularis	expressed conserved protein	0.0102	0.0874	0.078
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Echinococcus multilocularis	glutamate receptor NMDA	0.0246	0.2529	0.2452
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.0217	0.034
Echinococcus multilocularis	orexin receptor type 2	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0057	0.0356	0.3752
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	Niemann-Pick C1 protein precursor	0.0109	0.095	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Echinococcus granulosus	neuropeptide s receptor	0.0045	0.0217	0.034
Loa Loa (eye worm)	hypothetical protein	0.0097	0.0818	0.8618
Onchocerca volvulus		0.0045	0.0217	1
Brugia malayi	AKH receptor	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0217	0.034
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0045	0.0217	0.0002
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0045	0.0217	0.2282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Echinococcus multilocularis	neuropeptides capa receptor	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	sulfakinin receptor protein	0.0045	0.0217	0.2282
Schistosoma mansoni	hypothetical protein	0.0045	0.0217	0.0002
Brugia malayi	putative neuropeptide receptor NPR1	0.0045	0.0217	0.2282
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	orexin receptor type 2	0.0045	0.0217	0.034
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	serotonin receptor	0.0045	0.0217	0.034
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0	0.5
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	expressed conserved protein	0.0102	0.0874	0.2286
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0045	0.0217	0.0116
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0045	0.0217	0.2282
Echinococcus multilocularis	somatostatin receptor	0.0045	0.0217	0.0116
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0045	0.0217	0.034
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Echinococcus granulosus	sex peptide receptor	0.0045	0.0217	0.034
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0045	0.0217	0.034
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0217	0.034
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0045	0.0217	1
Echinococcus multilocularis	g protein coupled receptor	0.0045	0.0217	0.0116
Brugia malayi	G-protein coupled receptor	0.0045	0.0217	0.2282
Echinococcus granulosus	7tm_1 domain containing protein	0.0045	0.0217	0.034
Loa Loa (eye worm)	abnormal chemotaxis protein 14	0.0047	0.0236	0.2481
Trichomonas vaginalis	conserved hypothetical protein	0.0047	0.0236	0.5
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0217	0.0002
Echinococcus granulosus	Niemann Pick C1 protein	0.0155	0.1486	0.41
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	nmda type glutamate receptor	0.0329	0.3478	1
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0045	0.0217	0.2282
Brugia malayi	Dopamine receptor protein 2	0.0045	0.0217	0.2282
Echinococcus multilocularis	nmda type glutamate receptor	0.0329	0.3478	0.3411
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.0217	0.034
Echinococcus granulosus	tm gpcr rhodopsin	0.0045	0.0217	0.034
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	amine GPCR	0.0045	0.0217	0.0002
Echinococcus granulosus	rhodopsin orphan GPCR	0.0045	0.0217	0.034
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0045	0.0217	0.0116
Echinococcus multilocularis	neuropeptide receptor A26	0.0045	0.0217	0.0116
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0045	0.0217	0.0116
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0045	0.0217	0.0002
Echinococcus granulosus	allatostatin A receptor	0.0045	0.0217	0.034
Echinococcus granulosus	neuropeptides capa receptor	0.0045	0.0217	0.034
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0097	0.0818	0.8618
Echinococcus multilocularis	g-protein coupled receptor	0.0045	0.0217	0.0116
Mycobacterium ulcerans	glutamine-binding lipoprotein GlnH	0.0059	0.0382	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0045	0.0217	0.2282
Onchocerca volvulus		0.0045	0.0217	1
Onchocerca volvulus		0.0045	0.0217	1
Brugia malayi	larval opioid receptor	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	biogenic amine 5HT receptor	0.0045	0.0217	0.034
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0045	0.0217	0.034
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0045	0.0217	0.2282
Echinococcus multilocularis	serotonin receptor	0.0045	0.0217	0.0116
Echinococcus granulosus	g-protein coupled receptor	0.0045	0.0217	0.034
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0045	0.0217	0.0116
Schistosoma mansoni	neuropeptide receptor	0.0045	0.0217	0.0002
Echinococcus multilocularis	protein dispatched 1	0.0053	0.0311	0.0212
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0045	0.0217	0.0002
Brugia malayi	GnHR receptor homolog	0.0045	0.0217	0.2282
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0045	0.0217	0.0002
Mycobacterium leprae	PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE)	0.0026	0	0.5
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0045	0.0217	0.034
Echinococcus granulosus	somatostatin receptor	0.0045	0.0217	0.034
Echinococcus multilocularis	protein patched	0.0047	0.0236	0.0135
Schistosoma mansoni	myosin xvIII	0.0045	0.0217	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	G protein-coupled receptor F59B2.13	0.0045	0.0217	0.2282
Schistosoma mansoni	amine GPCR	0.0045	0.0217	0.0002
Onchocerca volvulus		0.0045	0.0217	1
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0045	0.0217	1
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0045	0.0217	0.2282
Schistosoma mansoni	biogenic amine receptor	0.0045	0.0217	0.0002
Schistosoma mansoni	neuropeptide F-like receptor	0.0045	0.0217	0.0002
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Brugia malayi	neuropeptide F receptor	0.0045	0.0217	0.2282
Brugia malayi	hypothetical protein	0.0045	0.0217	0.2282
Schistosoma mansoni	amine GPCR	0.0045	0.0217	0.0002
Echinococcus multilocularis	neuropeptide Y receptor	0.0045	0.0217	0.0116
Onchocerca volvulus		0.0045	0.0217	1
Brugia malayi	neuropeptide F receptor	0.0045	0.0217	0.2282
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0045	0.0217	0.0002
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0045	0.0217	0.0116
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus granulosus	g protein coupled receptor	0.0045	0.0217	0.034
Brugia malayi	Dopamine receptor	0.0045	0.0217	0.2282
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0045	0.0217	0.0002
Echinococcus granulosus	Niemann Pick C1 protein	0.0109	0.095	0.2511
Echinococcus multilocularis	sterol regulatory element binding protein	0.0047	0.0236	0.0135
Loa Loa (eye worm)	hypothetical protein	0.0045	0.0217	0.2282
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0045	0.0217	0.0116
Loa Loa (eye worm)	neuropeptide F receptor	0.0045	0.0217	0.2282

Activities

Activity type	Activity value	Assay description	Source	Reference
Activity (functional)	= 0	Ability to block a conditioned avoidance response; Dose administered perorally is 50 mg/kg.	ChEMBL.	6105216
Activity (functional)	= 0	Compound was assessed for its ability to produce catalepsy in rats; Dose administered perorally is 50 mg/kg; Group score is 0-3	ChEMBL.	6105216
EDmin (functional)	= 50 mg kg-1	Hypothermia in mice after peroral administration	ChEMBL.	6105216
EDmin (functional)	= 50 mg kg-1	Hypothermia in mice after peroral administration	ChEMBL.	6105216
LD50 (ADMET)	> 400 mg kg-1	Lethal dose in mice after perorla administration	ChEMBL.	6105216
LD50 (ADMET)	> 400 mg kg-1	Lethal dose in mice after perorla administration	ChEMBL.	6105216

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL355129

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 300073