Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | RNA helicase, putative | 0.0263 | 0.1308 | 0.5 |
Brugia malayi | hypothetical protein | 0.0141 | 0 | 0.5 |
Echinococcus granulosus | protoporphyrinogen oxidase | 0.0932 | 0.8485 | 1 |
Plasmodium falciparum | conserved Plasmodium protein, unknown function | 0.0141 | 0 | 0.5 |
Plasmodium falciparum | lysine-specific histone demethylase 1, putative | 0.0141 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase LSD1/BHC110/KDMA1A | 0.0141 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0 | 0.5 |
Brugia malayi | SWIRM domain containing protein | 0.0141 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0 | 0.5 |
Mycobacterium leprae | PROBABLE PROTOPORPHYRINOGEN OXIDASE HEMY (PROTOPORPHYRINOGEN-IX OXIDASE) (PROTOPORPHYRINOGENASE) (PPO) | 0.1073 | 1 | 0.5 |
Plasmodium vivax | lysine-specific histone demethylase 1, putative | 0.0141 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0141 | 0 | 0.5 |
Trypanosoma cruzi | UDP-galactopyranose mutase | 0.0141 | 0 | 0.5 |
Brugia malayi | amine oxidase, flavin-containing family protein | 0.0141 | 0 | 0.5 |
Mycobacterium ulcerans | protoporphyrinogen oxidase | 0.1073 | 1 | 1 |
Mycobacterium tuberculosis | Probable protoporphyrinogen oxidase HemY (protoporphyrinogen-IX oxidase) (protoporphyrinogenase) (PPO) | 0.0932 | 0.8485 | 1 |
Schistosoma mansoni | Protoporphyrinogen oxidase chloroplast/mitochondrial precursor | 0.1073 | 1 | 1 |
Echinococcus multilocularis | protoporphyrinogen oxidase | 0.1073 | 1 | 1 |
Leishmania major | UDP-galactopyranose mutase | 0.0141 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0263 | 0.1308 | 0.1308 |
Onchocerca volvulus | 0.0141 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0141 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0141 | 0 | 0.5 |
Plasmodium vivax | protoporphyrinogen oxidase, putative | 0.0141 | 0 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.0141 | 0 | 0.5 |
Toxoplasma gondii | histone lysine-specific demethylase | 0.0141 | 0 | 0.5 |
Plasmodium falciparum | protoporphyrinogen oxidase | 0.0141 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 0.03 ug ml-1 | Antibiotic activity was determined against Pseudomonas aeruginosa (5) | ChEMBL. | 3572975 |
MIC (functional) | = 0.5 ug ml-1 | Antibiotic activity was determined against Staphylococcus aureus (5) | ChEMBL. | 3572975 |
MIC (functional) | = 1.4 ug ml-1 | Antibiotic activity was determined against Klebsiella species (5) | ChEMBL. | 3572975 |
MIC (functional) | = 2.5 ug ml-1 | Antibiotic activity was determined against Escherichia coli(5) | ChEMBL. | 3572975 |
MIC (functional) | = 2.5 ug ml-1 | Antibiotic activity was determined against Escherichia coli(5) | ChEMBL. | 3572975 |
MIC (functional) | = 4.6 ug ml-1 | Antibiotic activity was determined against Enterobacter species (6) | ChEMBL. | 3572975 |
MIC (functional) | = 5.7 ug ml-1 | Antibiotic activity was determined against Enterococcus (3) | ChEMBL. | 3572975 |
MIC (functional) | = 10 ug ml-1 | Antibiotic activity was determined against Serratia species (2) | ChEMBL. | 3572975 |
MIC (functional) | = 10 ug ml-1 | Antibiotic activity was determined against Proteus species (5) | ChEMBL. | 3572975 |
Relative susceptibility (binding) | = 0.2 | Susceptibility to mammalian dehydropeptidase DHP-1 relative to thienamycin | ChEMBL. | 3572975 |
Relative susceptibility (binding) | = 0.2 | Susceptibility to mammalian dehydropeptidase DHP-1 relative to thienamycin | ChEMBL. | 3572975 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.