Detailed information for compound 301274

Basic information

Technical information
  • TDR Targets ID: 301274
  • Name: (7-butyl-1-azaspiro[5.5]undecan-8-yl) methyl carbonate
  • MW: 283.406 | Formula: C16H29NO3
  • H donors: 1 H acceptors: 1 LogP: 3.97 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCC1C(CCCC21CCCCN2)OC(=O)OC
  • InChi: 1S/C16H29NO3/c1-3-4-8-13-14(20-15(18)19-2)9-7-11-16(13)10-5-6-12-17-16/h13-14,17H,3-12H2,1-2H3
  • InChiKey: FNCKUAUKSKUJOM-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • carbonic acid (7-butyl-1-azaspiro[5.5]undecan-8-yl) methyl ester
  • 7-Butyl-1-azaspiro[5.5]undec-8-yl methyl carbonate
  • Perhydrohistrionicotoxin, 2-depentyl-, methoxyformate(ester)

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0049 0.0057 0.0726
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0087 0.0087
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0087 0.016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0251 0.0251
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0087 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0087 0.016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0087 0.016
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0251 0.0389
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Schistosoma mansoni hypothetical protein 0.0052 0.0087 0.016
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0087 0.0087
Echinococcus multilocularis serotonin receptor 0.0052 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus nmda type glutamate receptor 0.0494 0.4961 0.7686
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0087 0.0135
Schistosoma mansoni glutamate receptor NMDA 0.0538 0.5451 1
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0114 0.0765 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0087 0.016
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0048 0.0037 0.0068
Echinococcus multilocularis expressed conserved protein 0.0108 0.0707 0.0707
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0087 0.016
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0251 0.0389
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0067 0.0251 0.0251
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0087 0.0087
Brugia malayi AKH receptor 0.0052 0.0087 0.1113
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0115 0.0784 0.5
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0087 0.1113
Chlamydia trachomatis glutamine binding protein 0.0114 0.0765 0.5
Schistosoma mansoni myosin xvIII 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Brugia malayi G-protein coupled receptor 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 0.0074 0.0332 0.424
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0087 0.0135
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0087 0.0135
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0057 0.5
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0054 0.0111 0.5
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0115 0.0784 1
Brugia malayi Dopamine receptor 0.0052 0.0087 0.1113
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0087 0.0087
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0087 0.1113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0087 0.0087
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0103 0.065 0.8295
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0087 0.0135
Schistosoma mansoni hypothetical protein 0.0052 0.0087 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Echinococcus granulosus L aminoadipate semialdehyde 0.0074 0.0332 0.0515
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0087 0.016
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus hypothetical protein 0.0052 0.0087 0.0135
Brugia malayi neuropeptide F receptor 0.0052 0.0087 0.1113
Echinococcus multilocularis glutamate receptor 2 0.0067 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Schistosoma mansoni hypothetical protein 0.0048 0.0037 0.0068
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0087 0.0087
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0087 0.1113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0057 0.0057
Loa Loa (eye worm) hypothetical protein 0.0061 0.018 0.2294
Schistosoma mansoni amine GPCR 0.0052 0.0087 0.016
Schistosoma mansoni hypothetical protein 0.0048 0.0037 0.0068
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0087 0.0135
Echinococcus multilocularis nmda type glutamate receptor 0.0494 0.4961 0.4961
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0087 0.0087
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0087 0.0087
Schistosoma mansoni aminoadipate-semialdehyde dehydrogenase 0.0074 0.0332 0.061
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis serotonin receptor 0.0052 0.0087 0.0087
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0111 0.0203
Echinococcus granulosus glutamate receptor 2 0.0067 0.0251 0.0389
Schistosoma mansoni opsin-like receptor 0.0052 0.0087 0.016
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0087 0.0087
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0087 0.0135
Echinococcus granulosus expressed conserved protein 0.0108 0.0707 0.1095
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0087 0.0135
Echinococcus granulosus Niemann Pick C1 protein 0.0165 0.133 0.2061
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus allatostatin A receptor 0.0052 0.0087 0.0135
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0087 0.0087
Brugia malayi CHE-14 protein 0.0049 0.0057 0.0726
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0114 0.0765 0.5
Schistosoma mansoni hypothetical protein 0.0052 0.0087 0.016
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0087 0.0087
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0117 0.0804 0.1474
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0087 0.016
Schistosoma mansoni opsin-like receptor 0.0052 0.0087 0.016
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0087 0.0087
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0087 0.0135
Echinococcus granulosus g protein coupled receptor 0.0052 0.0087 0.0135
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0087 0.016
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0087 0.1113
Schistosoma mansoni neuropeptide receptor 0.0052 0.0087 0.016
Brugia malayi Dopamine receptor protein 2 0.0052 0.0087 0.1113
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0087 0.1113
Brugia malayi hypothetical protein 0.0103 0.065 0.8295
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0087 0.0087
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0114 0.0765 0.5
Brugia malayi Serotonin receptor 0.0052 0.0087 0.1113
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0087 0.1113
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0087 0.1113
Echinococcus granulosus somatostatin receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0087 0.0087
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0087 0.016
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0087 0.0135
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0087 0.016
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0087 0.0087
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0087 0.016
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Echinococcus granulosus g protein coupled receptor 0.0052 0.0087 0.0135
Schistosoma mansoni patched 1 0.0049 0.0057 0.0104
Echinococcus granulosus nmda type glutamate receptor 0.0629 0.6455 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis nmda type glutamate receptor 0.0629 0.6455 0.6455
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0087 0.1113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0087 0.0087
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0087 0.0087
Echinococcus multilocularis L aminoadipate semialdehyde 0.0074 0.0332 0.0332
Echinococcus multilocularis Niemann Pick C1 protein 0.0115 0.0784 0.0784
Toxoplasma gondii aldehyde dehydrogenase 0.0054 0.0111 0.5
Echinococcus granulosus sex peptide receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Schistosoma mansoni neuropeptide receptor 0.0052 0.0087 0.016
Brugia malayi Dopamine receptor protein 1 0.0052 0.0087 0.1113
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0067 0.0251 0.0389
Brugia malayi RE15519p 0.0052 0.0087 0.1113
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0087 0.0135
Schistosoma mansoni amine GPCR 0.0052 0.0087 0.016
Brugia malayi neuropeptide F receptor 0.0052 0.0087 0.1113
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0251 0.0251
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0087 0.0087
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi putative neuropeptide receptor 0.0052 0.0087 0.1113
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0054 0.0111 0.0171
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0087 0.0135
Schistosoma mansoni biogenic amine receptor 0.0052 0.0087 0.016
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0067 0.0251 0.0251
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0067 0.0251 0.0389
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0057 0.0088
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0103 0.065 0.8295
Schistosoma mansoni biogenic amine receptor 0.0052 0.0087 0.016
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0087 0.016
Brugia malayi G protein-coupled receptor 0.0052 0.0087 0.1113
Brugia malayi GnHR receptor homolog 0.0052 0.0087 0.1113
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0087 0.0135
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0087 0.0087
Echinococcus multilocularis sex peptide receptor 0.0052 0.0087 0.0087
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0087 0.0087
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi Melatonin receptor type 1A 0.0052 0.0087 0.1113
Schistosoma mansoni eyes absent homolog 0.0103 0.065 0.1193
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0087 0.0087
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis glutamate receptor NMDA 0.0471 0.471 0.471
Schistosoma mansoni opsin-like receptor 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Schistosoma mansoni biogenic amine receptor 0.0052 0.0087 0.016
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0087 0.0135
Brugia malayi G-protein coupled receptor 0.0052 0.0087 0.1113
Echinococcus granulosus Niemann Pick C1 protein 0.0115 0.0784 0.1215
Schistosoma mansoni hypothetical protein 0.0048 0.0037 0.0068
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0087 0.0135
Echinococcus granulosus neuropeptide receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0087 0.1113
Schistosoma mansoni aldehyde dehydrogenase 0.0054 0.0111 0.0203
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus neuropeptide receptor 0.0052 0.0087 0.0135
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0087 0.1113
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0087 0.0087
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0087 0.016
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0087 0.0087
Echinococcus multilocularis tumor protein p63 0.0303 0.2851 0.2851
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0087 0.1113
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0087 0.016
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0087 0.0135
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0087 0.016
Brugia malayi hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis Niemann Pick C1 protein 0.0165 0.133 0.133
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0087 0.0135
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0114 0.0765 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0087 0.0135
Echinococcus multilocularis protein patched 0.0049 0.0057 0.0057
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0087 0.0087
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0087 0.0135
Echinococcus granulosus glutamate receptor NMDA 0.0471 0.471 0.7297
Schistosoma mansoni amine GPCR 0.0052 0.0087 0.016
Echinococcus granulosus orexin receptor type 2 0.0052 0.0087 0.0135
Echinococcus multilocularis somatostatin receptor 0.0052 0.0087 0.0087
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0087 0.1113
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0087 0.1113
Schistosoma mansoni neuropeptide receptor 0.0052 0.0087 0.016
Echinococcus granulosus tumor protein p63 0.0303 0.2851 0.4417
Onchocerca volvulus 0.0074 0.0332 1
Schistosoma mansoni amine GPCR 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0332 0.424
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0087 0.0087
Brugia malayi ORL1-like opioid receptor 0.0052 0.0087 0.1113
Echinococcus multilocularis protein dispatched 1 0.0056 0.0134 0.0134
Echinococcus granulosus serotonin receptor 0.0052 0.0087 0.0135
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0087 0.016
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0087 0.0135
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0087 0.1113
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Echinococcus granulosus g protein coupled receptor 0.0052 0.0087 0.0135
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0087 0.0087
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0087 0.0135
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0087 0.0087
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0087 0.1113
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0087 0.0087
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0087 0.0087
Brugia malayi Niemann-Pick C1 protein precursor 0.0115 0.0784 1
Echinococcus granulosus fmrfamide receptor 0.0052 0.0087 0.0135
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0057 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0087 0.0087
Brugia malayi Serotonin receptor 0.0052 0.0087 0.1113
Brugia malayi larval opioid receptor 0.0052 0.0087 0.1113
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0087 0.0135
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0057 0.0726
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi sulfakinin receptor protein 0.0052 0.0087 0.1113
Schistosoma mansoni adenoreceptor 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0087 0.0087
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0087 0.0135
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0054 0.0111 0.0111
Schistosoma mansoni amine GPCR 0.0052 0.0087 0.016
Schistosoma mansoni histamine h1 receptor 0.0052 0.0087 0.016
Loa Loa (eye worm) hypothetical protein 0.0052 0.0087 0.1113
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0087 0.1113
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0114 0.0765 0.5
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0158 0.1255 0.1255
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0087 0.0135
Schistosoma mansoni neuropeptide receptor 0.0052 0.0087 0.016

Activities

Activity type Activity value Assay description Source Reference
Block (functional) = 14 % Percent block of sciatic nerve sartorius muscle twitch of frog 30 min after direct stimulation and exposure to 50 uM toxin for 60 min ChEMBL. 6288946
Block (functional) = 25 % Percent block of sciatic nerve sartorius muscle twitch of frog 60 min after direct stimulation and exposure to 50 uM toxin for 60 min ChEMBL. 6288946
Block (functional) = 67 % Percent block of sciatic nerve sartorius muscle twitch of frog 30 min after indirect stimulation and exposure to 50 uM toxin for 60 min ChEMBL. 6288946
Block (functional) = 82 % Percent block of sciatic nerve sartorius muscle twitch of frog 60 min after indirect stimulation and exposure to 50 uM toxin for 60 min ChEMBL. 6288946

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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