Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cyclin E2 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0202 | 0.0152 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1937 | 1 | 1 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0202 | 0.0152 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0202 | 0.0152 | 1 |
Plasmodium falciparum | cyclin | 0.0021 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0202 | 0.0152 | 1 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0202 | 0.0152 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0202 | 0.0152 | 1 |
Onchocerca volvulus | 0.0202 | 0.0152 | 1 | |
Echinococcus multilocularis | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Echinococcus granulosus | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1937 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0202 | 0.0152 | 1 |
Echinococcus multilocularis | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0202 | 0.0152 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0069 | 0.004 | 0.004 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0069 | 0.004 | 0.004 |
Giardia lamblia | Cyclin A | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0202 | 0.0152 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0202 | 0.0152 | 0.0152 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0202 | 0.0152 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0069 | 0.004 | 0.004 |
Trichomonas vaginalis | Esterase, putative | 0.0202 | 0.0152 | 1 |
Entamoeba histolytica | cyclin, putative | 0.0021 | 0 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.004 | 0.2642 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.004 | 0.004 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0202 | 0.0152 | 1 |
Giardia lamblia | Hypothetical protein | 0.0021 | 0 | 0.5 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0202 | 0.0152 | 0.5 |
Loa Loa (eye worm) | aryl-acylamidase | 0.0202 | 0.0152 | 0.0152 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0202 | 0.0152 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.1937 | 1 | 1 |
Entamoeba histolytica | cyclin family protein | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0202 | 0.0152 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0202 | 0.0152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.004 | 0.004 |
Mycobacterium leprae | Possible lipase LipU | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0202 | 0.0152 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0202 | 0.0152 | 0.5 |
Loa Loa (eye worm) | ammd protein | 0.0202 | 0.0152 | 0.0152 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0202 | 0.0152 | 1 |
Loa Loa (eye worm) | hypothetical protein | 1.1937 | 1 | 1 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0202 | 0.0152 | 0.5 |
Entamoeba histolytica | cyclin, putative | 0.0021 | 0 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0069 | 0.004 | 0.004 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0202 | 0.0152 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0202 | 0.0152 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0069 | 0.004 | 0.004 |
Mycobacterium ulcerans | lipase LipI | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0202 | 0.0152 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0202 | 0.0152 | 1 |
Brugia malayi | aryl-acylamidase | 0.0202 | 0.0152 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0202 | 0.0152 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0069 | 0.004 | 0.2642 |
Mycobacterium ulcerans | esterase LipC | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0202 | 0.0152 | 0.5 |
Giardia lamblia | G2/mitotic-specific cyclin B | 0.0021 | 0 | 0.5 |
Entamoeba histolytica | cyclin family protein | 0.0021 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0202 | 0.0152 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0202 | 0.0152 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.1937 | 1 | 1 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0069 | 0.004 | 0.004 |
Mycobacterium ulcerans | lipase LipH | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0202 | 0.0152 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0202 | 0.0152 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 4 nM | In vitro inhibition of recombinant Cyclin Dependent Kinase-2/Cyclin E. | ChEMBL. | 15012993 |
IC50 (binding) | = 4 nM | In vitro inhibition of recombinant Cyclin Dependent Kinase-2/Cyclin E. | ChEMBL. | 15012993 |
IC50 (functional) | = 80 nM | In vitro inhibition of SW480 (human colon cancer) cell proliferation. | ChEMBL. | 15012993 |
IC50 (functional) | = 80 nM | In vitro inhibition of SW480 (human colon cancer) cell proliferation. | ChEMBL. | 15012993 |
IC50 (functional) | = 300 nM | In vitro inhibition of MDA MB 435 (human breast cancer) cell proliferation. | ChEMBL. | 15012993 |
IC50 (functional) | = 300 nM | In vitro inhibition of MDA MB 435 (human breast cancer) cell proliferation. | ChEMBL. | 15012993 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15012993 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.