Detailed information for compound 301953

Basic information

Technical information
  • TDR Targets ID: 301953
  • Name: (3S)-3-amino-4-[[(2S)-1-hydroxy-3-(4-hydroxyp henyl)-1-oxopropan-2-yl]amino]-4-oxobutanoic acid
  • MW: 296.276 | Formula: C13H16N2O6
  • H donors: 5 H acceptors: 6 LogP: -2.89 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)C[C@@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)N
  • InChi: 1S/C13H16N2O6/c14-9(6-11(17)18)12(19)15-10(13(20)21)5-7-1-3-8(16)4-2-7/h1-4,9-10,16H,5-6,14H2,(H,15,19)(H,17,18)(H,20,21)/t9-,10-/m0/s1
  • InChiKey: NALWOULWGHTVDA-UWVGGRQHSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

  • (3S)-3-amino-4-[[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]-2-oxo-ethyl]amino]-4-oxo-butanoic acid
  • (3S)-3-amino-4-[[(1S)-2-hydroxy-1-[(4-hydroxyphenyl)methyl]-2-oxoethyl]amino]-4-oxobutanoic acid
  • (3S)-3-azanyl-4-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxo-propan-2-yl]amino]-4-oxo-butanoic acid
  • (3S)-3-amino-4-[[(1S)-2-hydroxy-1-(4-hydroxybenzyl)-2-keto-ethyl]amino]-4-keto-butyric acid
  • aspartyltyrosine
  • (3S)-3-amino-4-[[(2S)-1-hydroxy-3-(4-hydroxyphenyl)-1-oxo-propan-2-yl]amino]-4-oxo-butanoic acid
  • 22840-03-5
  • Asp-tyr
  • L-Tyrosine, N-L-alpha-aspartyl-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0052 0.0338 1
Schistosoma mansoni opsin-like receptor 0.0052 0.0338 0.0916
Brugia malayi larval opioid receptor 0.0052 0.0338 0.3341
Treponema pallidum amino acid ABC transporter, periplasmic binding protein (hisJ) 0.0075 0.0598 0.5
Echinococcus multilocularis Niemann Pick C1 protein 0.0113 0.1012 0.1012
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0069 0.068
Onchocerca volvulus 0.0039 0.0197 0.5835
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0338 0.0338
Loa Loa (eye worm) melatonin receptor type 1A 0.0052 0.0338 0.3341
Onchocerca volvulus 0.0039 0.0197 0.5835
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0259 0.0259
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0197 0.1949
Mycobacterium tuberculosis Probable glutamine-binding lipoprotein GlnH (GLNBP) 0.0075 0.0598 1
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0197 0.1949
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0039 0.0197 0.0453
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Schistosoma mansoni amine GPCR 0.0052 0.0338 0.0916
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0069 0.5
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0052 0.0338 0.3341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0052 0.0338 0.3341
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0039 0.0197 0.0197
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni glutamate receptor AMPA 0.0029 0.0093 0.0252
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0052 0.0338 0.3341
Schistosoma mansoni glutamate receptor NMDA 0.0029 0.0093 0.0252
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Loa Loa (eye worm) TYRA-2 protein 0.0052 0.0338 0.3341
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0052 0.0338 0.0338
Brugia malayi GnHR receptor homolog 0.0052 0.0338 0.3341
Echinococcus multilocularis neuropeptide receptor A26 0.0052 0.0338 0.0338
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0338 0.0338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Brugia malayi Glutamate receptor 1 precursor 0.0029 0.0093 0.0919
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0338 0.0776
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0338 0.0916
Schistosoma mansoni amine GPCR 0.0052 0.0338 0.0916
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0093 0.0252
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Onchocerca volvulus 0.0027 0.0069 0.2035
Echinococcus multilocularis glutamate receptor 2 0.0029 0.0093 0.0093
Onchocerca volvulus 0.0039 0.0197 0.5835
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0113 0.1012 1
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0039 0.0197 0.0453
Onchocerca volvulus Neuropeptide F receptor homolog 0.0052 0.0338 1
Schistosoma mansoni neuropeptide receptor 0.0052 0.0338 0.0916
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Echinococcus granulosus hypothetical protein 0.0052 0.0338 0.0776
Echinococcus multilocularis g-protein coupled receptor 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0259 0.0259
Schistosoma mansoni amine GPCR 0.0052 0.0338 0.0916
Echinococcus multilocularis G-protein coupled receptor, putative 0.0052 0.0338 0.0338
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0093 0.0252
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0338 0.0776
Schistosoma mansoni glutamate receptor AMPA 0.0029 0.0093 0.0252
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0338 0.3341
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0039 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Trichomonas vaginalis conserved hypothetical protein 0.0049 0.0303 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 2 0.0045 0.0259 0.0259
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0052 0.0338 0.0776
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0338 0.0916
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0338 0.0916
Brugia malayi sulfakinin receptor protein 0.0052 0.0338 0.3341
Schistosoma mansoni adenoreceptor 0.0052 0.0338 0.0916
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0259 0.0594
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi putative neuropeptide receptor NPR1 0.0052 0.0338 0.3341
Loa Loa (eye worm) glutamate receptor 2 0.0029 0.0093 0.0919
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Brugia malayi putative neuropeptide receptor 0.0052 0.0338 0.3341
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0039 0.0197 0.0534
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.068
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis nmda type glutamate receptor 0.0328 0.3368 0.3368
Echinococcus multilocularis glycine receptor subunit beta 0.0039 0.0197 0.0197
Echinococcus multilocularis Ribosomal protein S1, RNA binding domain 0.0029 0.0093 0.0093
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0039 0.0197 0.0453
Brugia malayi excitatory GABA receptor EXP-1A 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0039 0.0197 0.1949
Echinococcus granulosus glutamate receptor ionotropic kainate 0.0029 0.0093 0.0213
Echinococcus multilocularis sex peptide receptor 0.0052 0.0338 0.0338
Echinococcus granulosus glycine receptor subunit alpha 1 0.0039 0.0197 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Echinococcus multilocularis Glutamate receptor, ionotropic kainate 3 0.0105 0.0922 0.0922
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0338 0.0338
Schistosoma mansoni neuropeptide f receptor 76f 0.0052 0.0338 0.0916
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Echinococcus multilocularis allatostatin A receptor 0.0052 0.0338 0.0338
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0039 0.0197 0.1949
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0039 0.0197 0.0197
Echinococcus granulosus g protein coupled receptor 0.0052 0.0338 0.0776
Brugia malayi Serotonin receptor 0.0052 0.0338 0.3341
Schistosoma mansoni biogenic amine (5HT) receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) ACC-1 protein 0.0039 0.0197 0.1949
Brugia malayi neuropeptide F receptor 0.0052 0.0338 0.3341
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0069 0.5
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0039 0.0197 0.0453
Echinococcus granulosus dro:myosuppressin receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0052 0.0338 0.3341
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0338 0.0338
Schistosoma mansoni hypothetical protein 0.0047 0.0283 0.0768
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0197 0.1949
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0039 0.0197 0.0197
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0039 0.0197 0.0197
Brugia malayi Serotonin receptor 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Onchocerca volvulus 0.0052 0.0338 1
Chlamydia trachomatis arginine ABC transporter substrate-binding protein ArtJ 0.0075 0.0598 0.5
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0039 0.0197 0.0534
Echinococcus granulosus fmrfamide receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus nAChR subunit 0.0039 0.0197 0.0453
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0338 0.0776
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0039 0.0197 0.1949
Brugia malayi Dopamine receptor protein 1 0.0052 0.0338 0.3341
Echinococcus multilocularis glycine receptor subunit beta 0.0039 0.0197 0.0197
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0052 0.0338 1
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus granulosus serotonin receptor 0.0052 0.0338 0.0776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0259 0.0594
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.0069 0.068
Echinococcus multilocularis glutamate receptor subunit protein glur 0.0029 0.0093 0.0093
Brugia malayi Cation transporter family protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) ACC-1 protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Echinococcus granulosus alpha 1A adrenergic receptor 0.0052 0.0338 0.0776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0338 0.0776
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Brugia malayi G-protein coupled receptor 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0052 0.0338 0.3341
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0039 0.0197 0.0197
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0039 0.0197 0.0197
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0052 0.0338 0.0338
Echinococcus granulosus neuropeptide receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0069 0.068
Schistosoma mansoni patched 1 0.0049 0.0303 0.082
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0338 0.0338
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0069 0.5
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis g protein coupled receptor 0.0052 0.0338 0.0338
Echinococcus granulosus glycine receptor subunit beta 0.0039 0.0197 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus glycine receptor subunit beta 0.0039 0.0197 0.0453
Brugia malayi RE15519p 0.0052 0.0338 0.3341
Brugia malayi Niemann-Pick C1 protein precursor 0.0113 0.1012 1
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0052 0.0338 0.0916
Onchocerca volvulus 0.0052 0.0338 1
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0039 0.0197 0.1949
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0052 0.0338 0.0916
Brugia malayi G protein-coupled receptor F59B2.13 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0052 0.0338 0.0916
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0069 0.5
Schistosoma mansoni neuropeptide receptor 0.0052 0.0338 0.0916
Chlamydia trachomatis glutamine binding protein 0.0075 0.0598 0.5
Echinococcus granulosus 7TM GPCR rhodopsin 0.0052 0.0338 0.0776
Schistosoma mansoni glutamate receptor NMDA 0.0357 0.3691 1
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus granulosus glutamate receptor subunit protein glur 0.0029 0.0093 0.0213
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.0069 0.5
Echinococcus granulosus nmda type glutamate receptor 0.0328 0.3368 0.7735
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0039 0.0197 0.1949
Brugia malayi Glutamate receptor 2 precursor 0.0029 0.0093 0.0919
Schistosoma mansoni amine GPCR 0.0052 0.0338 0.0916
Echinococcus multilocularis neuropeptides capa receptor 0.0052 0.0338 0.0338
Echinococcus multilocularis glutamate receptor, ionotrophic, AMPA 3 0.0045 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Treponema pallidum amino acid ABC transporter, periplasmic binding protein 0.0075 0.0598 0.5
Brugia malayi Melatonin receptor type 1A 0.0052 0.0338 0.3341
Echinococcus granulosus neuropeptide receptor A26 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0039 0.0197 0.0197
Brugia malayi hypothetical protein 0.0101 0.0881 0.8712
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0039 0.0197 0.0534
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0338 0.0338
Echinococcus multilocularis serotonin receptor 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Echinococcus multilocularis protein patched 0.0049 0.0303 0.0303
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0338 0.0776
Schistosoma mansoni nAChR subunit 0.0039 0.0197 0.0534
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus expressed conserved protein 0.0106 0.0936 0.2151
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus Protein patched homolog 1 0.0049 0.0303 0.0695
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi AKH receptor 0.0052 0.0338 0.3341
Schistosoma mansoni hypothetical protein 0.0029 0.0093 0.0252
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0069 0.068
Echinococcus granulosus Niemann Pick C1 protein 0.0162 0.1545 0.3548
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.0069 0.068
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0052 0.0338 0.3341
Schistosoma mansoni neuropeptide receptor 0.0052 0.0338 0.0916
Echinococcus multilocularis neuropeptide Y receptor 0.0052 0.0338 0.0338
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0052 0.0338 0.0776
Echinococcus granulosus glycine receptor subunit alpha 1 0.0039 0.0197 0.0453
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0052 0.0338 0.3341
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0338 0.0338
Schistosoma mansoni biogenic amine receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0338 0.3341
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0052 0.0338 0.3341
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0338 0.0338
Echinococcus granulosus G protein coupled receptor 139 0.0052 0.0338 0.0776
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0113 0.1012 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Schistosoma mansoni histamine h1 receptor 0.0052 0.0338 0.0916
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0101 0.0881 0.8712
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0039 0.0197 0.1949
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0039 0.0197 0.1949
Echinococcus multilocularis neuropeptide s receptor 0.0052 0.0338 0.0338
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0052 0.0338 0.0338
Brugia malayi ORL1-like opioid receptor 0.0052 0.0338 0.3341
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0052 0.0338 0.0916
Echinococcus granulosus neuropeptide Y receptor 0.0052 0.0338 0.0776
Echinococcus granulosus 7tm_1 domain containing protein 0.0052 0.0338 0.0776
Schistosoma mansoni hypothetical protein 0.0047 0.0283 0.0768
Brugia malayi Dopamine receptor 0.0052 0.0338 0.3341
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0039 0.0197 0.0197
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0049 0.0303 0.2992
Echinococcus granulosus peptide allatostatin:somatostatin 0.0052 0.0338 0.0776
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0069 0.068
Schistosoma mansoni biogenic amine receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus granulosus somatostatin receptor 0.0052 0.0338 0.0776
Echinococcus multilocularis glutamate receptor 2 0.0045 0.0259 0.0259
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Echinococcus granulosus neuropeptide s receptor 0.0052 0.0338 0.0776
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0052 0.0338 0.3341
Echinococcus multilocularis glutamate receptor ionotropic kainate 0.0029 0.0093 0.0093
Schistosoma mansoni neuropeptide F-like receptor 0.0052 0.0338 0.0916
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Echinococcus multilocularis expressed conserved protein 0.0106 0.0936 0.0936
Echinococcus granulosus tm gpcr rhodopsin 0.0052 0.0338 0.0776
Echinococcus granulosus g-protein coupled receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0052 0.0338 0.0338
Echinococcus granulosus Ribosomal protein S1 RNA binding domain 0.0029 0.0093 0.0213
Loa Loa (eye worm) hypothetical protein 0.0059 0.0423 0.4177
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.068
Brugia malayi Cation transporter family protein 0.0039 0.0197 0.1949
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0052 0.0338 0.0776
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0039 0.0197 0.1949
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi Cation transporter family protein 0.0039 0.0197 0.1949
Onchocerca volvulus 0.0039 0.0197 0.5835
Echinococcus multilocularis orexin receptor type 2 0.0052 0.0338 0.0338
Loa Loa (eye worm) LGC-31 protein 0.0039 0.0197 0.1949
Echinococcus granulosus g protein coupled receptor 0.0052 0.0338 0.0776
Echinococcus multilocularis glutamate receptor NMDA 0.0312 0.3202 0.3202
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0039 0.0197 0.0534
Brugia malayi CHE-14 protein 0.0049 0.0303 0.2992
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0039 0.0197 0.1949
Echinococcus multilocularis neuropeptide FF receptor 2 0.0052 0.0338 0.0338
Schistosoma mansoni hypothetical protein 0.0047 0.0283 0.0768
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0101 0.0881 0.8712
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0039 0.0197 0.0534
Echinococcus granulosus neuropeptide receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi neuropeptide F receptor 0.0052 0.0338 0.3341
Loa Loa (eye worm) G-protein coupled receptor 0.0052 0.0338 0.3341
Onchocerca volvulus 0.0052 0.0338 1
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus glutamate receptor NMDA 0.0312 0.3202 0.7355
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0338 0.0338
Schistosoma mansoni growth hormone secretagogue receptor 0.0052 0.0338 0.0916
Echinococcus multilocularis glutamate (NMDA) receptor subunit 0.0029 0.0093 0.0093
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Echinococcus multilocularis Niemann Pick C1 protein 0.0162 0.1545 0.1545
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus granulosus glutamate receptor 2 0.0045 0.0259 0.0594
Onchocerca volvulus 0.0039 0.0197 0.5835
Echinococcus granulosus glutamate receptor ionotrophic AMPA 3 0.0045 0.0259 0.0594
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0338 0.0338
Schistosoma mansoni hypothetical protein 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni myosin xvIII 0.0052 0.0338 0.0916
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0039 0.0197 0.1949
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0052 0.0338 0.0776
Echinococcus multilocularis dro:myosuppressin receptor 0.0052 0.0338 0.0338
Onchocerca volvulus 0.0039 0.0197 0.5835
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0039 0.0197 0.1949
Schistosoma mansoni opsin-like receptor 0.0052 0.0338 0.0916
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0115 0.1031 0.2793
Echinococcus multilocularis somatostatin receptor 0.0052 0.0338 0.0338
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0052 0.0338 0.0916
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0052 0.0338 0.0916
Schistosoma mansoni amine GPCR 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Echinococcus multilocularis neuropeptide receptor 0.0052 0.0338 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0039 0.0197 0.0453
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus Niemann Pick C1 protein 0.0113 0.1012 0.2324
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus allatostatin A receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.068
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0039 0.0197 0.1949
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi G protein-coupled receptor 0.0052 0.0338 0.3341
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0049 0.0303 0.2992
Onchocerca volvulus 0.0052 0.0338 1
Onchocerca volvulus 0.0052 0.0338 1
Schistosoma mansoni glutamate receptor kainate 0.0029 0.0093 0.0252
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni alpha-1 adrenergic receptor 0.0052 0.0338 0.0916
Echinococcus granulosus Glutamate receptor ionotropic kainate 2 0.0045 0.0259 0.0594
Echinococcus granulosus tachykinin peptides receptor 99D 0.0052 0.0338 0.0776
Echinococcus multilocularis protein dispatched 1 0.0055 0.0378 0.0378
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0052 0.0338 0.0916
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni hypothetical protein 0.0052 0.0338 0.0916
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0039 0.0197 0.1949
Echinococcus granulosus neuropeptides capa receptor 0.0052 0.0338 0.0776
Echinococcus granulosus biogenic amine 5HT receptor 0.0052 0.0338 0.0776
Schistosoma mansoni hypothetical protein 0.0047 0.0283 0.0768
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0039 0.0197 0.0453
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0052 0.0338 0.0916
Echinococcus granulosus sex peptide receptor 0.0052 0.0338 0.0776
Onchocerca volvulus Putative nachr subunit 0.0039 0.0197 0.5835
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Schistosoma mansoni biogenic amine receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis sterol regulatory element binding protein 0.0049 0.0303 0.0303
Onchocerca volvulus 0.0052 0.0338 1
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0039 0.0197 0.1949
Onchocerca volvulus 0.0052 0.0338 1
Schistosoma mansoni ATP-binding cassette transporter 0.0029 0.0093 0.0252
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0052 0.0338 0.0338
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0052 0.0338 0.0776
Echinococcus granulosus neuropeptide FF receptor 2 0.0052 0.0338 0.0776
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni neuropeptide receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus orexin receptor type 2 0.0052 0.0338 0.0776
Echinococcus multilocularis rhodopsin orphan GPCR 0.0052 0.0338 0.0338
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Brugia malayi Dopamine receptor protein 2 0.0052 0.0338 0.3341
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0052 0.0338 0.0916
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0052 0.0338 0.0338
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) glutamate receptor 1 0.0029 0.0093 0.0919
Onchocerca volvulus 0.0052 0.0338 1
Schistosoma mansoni hypothetical protein 0.0052 0.0338 0.0916
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0052 0.0338 0.3341
Loa Loa (eye worm) neuropeptide F receptor 0.0052 0.0338 0.3341
Schistosoma mansoni eyes absent homolog 0.0101 0.0881 0.2388
Echinococcus granulosus glutamate receptor ionotropic kainate 3 0.0029 0.0093 0.0213
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Schistosoma mansoni hypothetical protein 0.0052 0.0338 0.0916
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0039 0.0197 0.0534
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0039 0.0197 0.0453
Mycobacterium ulcerans glutamine-binding lipoprotein GlnH 0.0075 0.0598 1
Echinococcus granulosus glycine receptor subunit alpha 1 0.0039 0.0197 0.0453
Schistosoma mansoni opsin-like receptor 0.0052 0.0338 0.0916
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341
Echinococcus multilocularis G protein coupled receptor 139 0.0052 0.0338 0.0338
Echinococcus multilocularis NMDA receptor 0.0029 0.0093 0.0093
Echinococcus multilocularis serotonin receptor 0.0052 0.0338 0.0338
Echinococcus granulosus rhodopsin orphan GPCR 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus nmda type glutamate receptor 0.0417 0.4354 1
Brugia malayi G-protein coupled receptor 0.0052 0.0338 0.3341
Echinococcus granulosus sterol regulatory element binding protein 0.0049 0.0303 0.0695
Echinococcus multilocularis nAChR subunit 0.0039 0.0197 0.0197
Loa Loa (eye worm) hypothetical protein 0.0039 0.0197 0.1949
Echinococcus multilocularis nmda type glutamate receptor 0.0417 0.4354 0.4354
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0039 0.0197 0.0453
Echinococcus granulosus g protein coupled receptor 0.0052 0.0338 0.0776
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Echinococcus granulosus glutamate NMDA receptor subunit 0.0029 0.0093 0.0213
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0039 0.0197 0.1949
Brugia malayi follicle stimulating hormone receptor 0.0052 0.0338 0.3341
Loa Loa (eye worm) hypothetical protein 0.0052 0.0338 0.3341
Onchocerca volvulus 0.0052 0.0338 1
Echinococcus multilocularis fmrfamide receptor 0.0052 0.0338 0.0338
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0052 0.0338 0.0338
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0039 0.0197 0.0197
Brugia malayi Tachykinin-like peptides receptor 99D 0.0052 0.0338 0.3341
Brugia malayi hypothetical protein 0.0052 0.0338 0.3341

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) > 5000 uM Inhibition potency against Cholecystokinin-8-Inactivating Peptidase (Serine Peptidase). ChEMBL. 10691692
logIC50 (binding) = 2 Inhibition of ACE (unknown origin) ChEMBL. 25016232
Taste class (functional) = 0 Quality of taste by acting at receptor site; Bitter ChEMBL. 3712380

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

2 literature references were collected for this gene.

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