Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Kelch motif family protein | 0.011 | 0.1447 | 0.143 |
Echinococcus granulosus | integrin beta 2 | 0.0493 | 0.8548 | 1 |
Onchocerca volvulus | 0.004 | 0.0149 | 1 | |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.018 | 0.2743 | 1 |
Schistosoma mansoni | integrin beta subunit | 0.0392 | 0.6674 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0179 | 0.0159 |
Loa Loa (eye worm) | AStacin protease | 0.0063 | 0.0588 | 0.0569 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0101 | 0.1292 | 0.1491 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0101 | 0.1292 | 0.1274 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.011 | 0.1447 | 0.143 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.1215 | 0.1198 |
Loa Loa (eye worm) | hypothetical protein | 0.0101 | 0.1288 | 0.127 |
Echinococcus granulosus | Tolloid protein 1 | 0.0101 | 0.1292 | 0.1491 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.004 | 0.0149 | 0.5 |
Echinococcus multilocularis | fibrillin 1 | 0.0054 | 0.0417 | 0.0466 |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.018 | 0.2743 | 1 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.018 | 0.2743 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0493 | 0.8548 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0033 | 0.002 | 0.5 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0033 | 0.002 | 0.5 |
Brugia malayi | hypothetical protein | 0.0101 | 0.1288 | 0.127 |
Loa Loa (eye worm) | integrin beta-2 | 0.0572 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.000049 M | In vitro inhibitory concentration against beef liver dihydrofolate reductase | ChEMBL. | 4009615 |
IC50 (binding) | = 0.000077 M | In vitro inhibitory concentration against Lactobacillus casei thymidylate synthetase | ChEMBL. | 4009615 |
IC50 (functional) | > 0.0001 M | Inhibitory concentration against the growth of L1210 murine leukemia cells in tissue culture. | ChEMBL. | 4009615 |
IC50 (functional) | = 16.2 nM | Tested in vitro for inhibitory concentration against CCRF-CEM human Leukemic lymphoblast by using GAR FTase as primary target | ChEMBL. | 8035423 |
Km app (binding) | = 157 M | Activity(apparent Km ) of the compound was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . | ChEMBL. | 4009615 |
Relative activity (functional) | = 6.8 | Tested in vitro for relative activity against CCRF-CEM human Leukemic lymphoblast by using GAR FTase as primary target | ChEMBL. | 8035423 |
Relative Km (binding) | = 0.68 | Activity(relative Km ) of the compound was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . | ChEMBL. | 4009615 |
Relative Vmax (binding) | = 0.9 | Activity(relative Vmax) of the compound was evaluated in vitro by purified mouse liver folate polyglutamate synthetase (FPGS) . | ChEMBL. | 4009615 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.