Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 100 uM | Antiviral activity against human cytomegalovirus (HCM virus) in plaque assay | ChEMBL. | 8632412 |
IC50 (functional) | > 100 uM | Antiviral activity against herpes simplex virus type 1 (HSV-1) in an ELISA assay | ChEMBL. | 8632412 |
IC50 (functional) | > 100 uM | Visual cytotoxicity of compound on HFF cells at time of HCMV plaque enumeration | ChEMBL. | 8632412 |
IC50 (functional) | > 100 uM | Inhibitory activity of compound against KB cell growth [>-indicates IC50/IC90 was not reached at the noted (highest)concentration tested] | ChEMBL. | 8632412 |
IC50 (functional) | > 100 uM | Visual cytotoxicity of compound on HFF cells at time of HCMV plaque enumeration | ChEMBL. | 8632412 |
IC50 (functional) | > 100 uM | Inhibitory activity of compound against KB cell growth [>-indicates IC50/IC90 was not reached at the noted (highest)concentration tested] | ChEMBL. | 8632412 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.