Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 0.0781 | 1 | 1 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.0442 | 0.518 | 1 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.0442 | 0.518 | 0.518 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.0442 | 0.518 | 0.518 |
Loa Loa (eye worm) | hypothetical protein | 0.0367 | 0.4102 | 0.4102 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.0442 | 0.518 | 0.518 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0718 | 0.9093 | 0.5 |
Brugia malayi | ERG2 and Sigma1 receptor like protein | 0.0718 | 0.9093 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 1 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0781 | 1 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0718 | 0.9093 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0781 | 1 | 1 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0718 | 0.9093 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.0442 | 0.518 | 0.518 |
Brugia malayi | vesicular acetylcholine transporter unc-17 | 0.0442 | 0.518 | 0.5696 |
Loa Loa (eye worm) | hypothetical protein | 0.0718 | 0.9093 | 0.9093 |
Loa Loa (eye worm) | hypothetical protein | 0.0781 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
K ass (binding) | = 400000 l M-1 | Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. | ChEMBL. | 10715154 |
K ass (binding) | = 400000 l M-1 | Binding affinity for coagulation factor X as apparent association constant (Kass) derived from protease inhibition kinetics. | ChEMBL. | 10715154 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.