Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | CXXC zinc finger family protein | 0.0029 | 0.1299 | 0.1051 |
Echinococcus multilocularis | geminin | 0.017 | 0.8547 | 0.8519 |
Echinococcus multilocularis | cpg binding protein | 0.003 | 0.1384 | 0.1219 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0198 | 1 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Schistosoma mansoni | cpg binding protein | 0.0029 | 0.1299 | 0.1271 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0155 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0198 | 1 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1384 | 0.1356 |
Brugia malayi | CXXC zinc finger family protein | 0.0029 | 0.1299 | 0.1056 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Onchocerca volvulus | 0.0198 | 1 | 1 | |
Trichomonas vaginalis | helicase, putative | 0.0007 | 0.0155 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0198 | 1 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0198 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0198 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 0.0198 | 1 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0061 | 0.2957 | 0.2935 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.008 | 0.3948 | 0.3928 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.0198 | 1 | 1 |
Echinococcus granulosus | geminin | 0.017 | 0.8547 | 0.8519 |
Echinococcus granulosus | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0278 | 0.0092 |
Schistosoma mansoni | sodium-bile acid cotransporter | 0.0118 | 0.5872 | 0.5859 |
Toxoplasma gondii | histone lysine methyltransferase SET1 | 0.0055 | 0.2622 | 0.5 |
Trichomonas vaginalis | chromodomain-helicase-DNA-binding protein, putative | 0.0007 | 0.0155 | 1 |
Echinococcus granulosus | sodium bile acid cotransporter | 0.0198 | 1 | 1 |
Echinococcus multilocularis | histone lysine N methyltransferase MLL3 | 0.0009 | 0.0278 | 0.0092 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0155 | 1 |
Schistosoma mansoni | mixed-lineage leukemia protein mll | 0.0007 | 0.0188 | 0.0156 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.8547 | 0.8542 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Schistosoma mansoni | cpg binding protein | 0.003 | 0.1384 | 0.1356 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Echinococcus granulosus | cpg binding protein | 0.003 | 0.1384 | 0.1219 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0007 | 0.0155 | 1 |
Trichomonas vaginalis | chromodomain helicase DNA binding protein, putative | 0.0007 | 0.0155 | 1 |
Schistosoma mansoni | hypothetical protein | 0.017 | 0.8547 | 0.8542 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 0.84 uM | Inhibition of spontaneous tone in guinea pig isolated trachealis | ChEMBL. | 2002472 |
Intrinsic activity (functional) | = 0.95 | Intrinsic activity was measured for inhibition of spontaneous tone in guinea pig isolated trachealis | ChEMBL. | 2002472 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.