Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 1.4997 | 1 | 1 |
Onchocerca volvulus | 0.0254 | 0 | 0.5 | |
Mycobacterium tuberculosis | Probable acetyl-hydrolase/esterase LipR | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipI | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipM | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipH | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Putative acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | acetyl hydrolase MbtJ | 0.0254 | 0 | 0.5 |
Brugia malayi | aryl-acylamidase | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipW | 0.0254 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0254 | 0 | 0.5 |
Mycobacterium leprae | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase LipH | 0.0254 | 0 | 0.5 |
Leishmania major | ecotin, putative | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Mycobacterium ulcerans | lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Trypanosoma brucei | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipC | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | esterase LipO | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Echinococcus multilocularis | hormone sensitive lipase | 1.4997 | 1 | 0.5 |
Treponema pallidum | N-acetylphosphinothricin-tripetide-deacetylase | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipO | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase LipC | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Alpha/beta hydrolase domain-containing protein | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable non lipolytic carboxylesterase NlhH | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | Isoprenylcysteine alpha-carbonyl methylesterase, putative | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Possible esterase LipW | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | membrane-bound esterase LipM | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | lipase LipU | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable lipase/esterase LipN | 0.0254 | 0 | 0.5 |
Mycobacterium ulcerans | carboxylesterase LipQ | 0.0254 | 0 | 0.5 |
Toxoplasma gondii | alpha/beta hydrolase fold domain-containing protein | 0.0254 | 0 | 0.5 |
Trichomonas vaginalis | Esterase, putative | 0.0254 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S9D | 0.0254 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable esterase/lipase LipF | 0.0254 | 0 | 0.5 |
Schistosoma mansoni | hormone-sensitive lipase (S09 family) | 1.4997 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 74 % | Compound was measured for percentage inhibition of aspirin-induced ulcers at 30 mg/kg after po administration | ChEMBL. | 7328596 |
Reduction (functional) | < 30 % | Antisecretory activity was evaluated in adult mongrel dog after po administration of the compound at 8 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 35 % | Antisecretory activity was evaluated in adult mongrel dog after iv administration at 5 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Reduction (functional) | = 95 % | Antisecretory activity was evaluated in pylorus ligated rat after iv administration at 40 mg/kg of dose, expressed as reduction of gastric output | ChEMBL. | 7328596 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.