Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | gtp binding protein (I) alpha 1subunit | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.033 | 0.6228 | 0.4303 | |
Echinococcus granulosus | gtp binding protein I alpha 1subunit | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 0.033 | 0.6228 | 1 |
Schistosoma mansoni | trimeric G-protein alpha o subunit | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0008 | 0 | 0.5 |
Leishmania major | phospholipase A1, putative | 0.033 | 0.6228 | 0.5 |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0008 | 0 | 0.5 |
Trichomonas vaginalis | GTP-binding protein alpha subunit, gna, putative | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0008 | 0 | 0.5 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0008 | 0 | 0.5 |
Brugia malayi | Platelet-activating factor acetylhydrolase, plasma/intracellular isoform II family protein | 0.033 | 0.6228 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0008 | 0 | 0.5 |
Echinococcus multilocularis | guanine nucleotide binding protein (G protein) | 0.0008 | 0 | 0.5 |
Trypanosoma cruzi | phospholipase A1, putative | 0.033 | 0.6228 | 1 |
Trichomonas vaginalis | G protein (olf) alpha subunit, gnal, putative | 0.0008 | 0 | 0.5 |
Loa Loa (eye worm) | platelet-activating factor acetylhydrolase | 0.033 | 0.6228 | 0.6228 |
Schistosoma mansoni | GTP-binding protein (I) alpha-2 subunit gnai2 | 0.0008 | 0 | 0.5 |
Echinococcus granulosus | guanine nucleotide binding protein G protein | 0.0008 | 0 | 0.5 |
Entamoeba histolytica | G protein alpha subunit, putative | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | Phospholipase A2 homolog | 0.0525 | 1 | 1 |
Onchocerca volvulus | 0.033 | 0.6228 | 0.4303 | |
Schistosoma mansoni | GTP-binding protein (I) alpha-1subunit gnai1 | 0.0008 | 0 | 0.5 |
Onchocerca volvulus | 0.033 | 0.6228 | 0.4303 | |
Loa Loa (eye worm) | hypothetical protein | 0.0183 | 0.3379 | 0.3379 |
Trypanosoma brucei | phospholipase A1, putative | 0.033 | 0.6228 | 0.5 |
Trichomonas vaginalis | GTP-binding protein (z) alpha subunit, gnaz, putative | 0.0008 | 0 | 0.5 |
Brugia malayi | Phospholipase A2 family protein | 0.0183 | 0.3379 | 0.5425 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Log 1/C (binding) | = 6.6 | The concentration of the compound required to inhibit dihydrofolate reductase in rat liver | ChEMBL. | 6737433 |
Log 1/C (binding) | = 6.6 | The concentration of the compound required to inhibit dihydrofolate reductase in rat liver | ChEMBL. | 6737433 |
log(1/I50) (binding) | = 8.64 | Inhibition of dihydrofolate reductase in mouse L1210R cells | ChEMBL. | 110930 |
log(1/I50) (binding) | = 8.66 | Inhibition of dihydrofolate reductase in human acute lymphocytic leukemia cells | ChEMBL. | 110930 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.