Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Escherichia coli | Dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | dihydrofolate reductase family protein | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0184 | 0.5676 | 0.5676 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0 | 0.5 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0 | 0.5 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0184 | 0.5676 | 0.5676 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0227 | 0.8021 | 1 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0079 | 0 | 0.5 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0079 | 0 | 0.5 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0079 | 0 | 0.5 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0079 | 0 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0079 | 0 | 0.5 |
Brugia malayi | Dihydrofolate reductase | 0.0079 | 0 | 0.5 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0093 | 0.0737 | 0.0737 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0079 | 0 | 0.5 |
Echinococcus granulosus | glutamate receptor NMDA | 0.017 | 0.4949 | 0.4949 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0263 | 1 | 1 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0079 | 0 | 0.5 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.017 | 0.4949 | 0.4949 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 42000000 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
I50 (binding) | = 2000000000000 M | Inhibition of rat liver Dihydrofolate reductase. | ChEMBL. | 7035668 |
IC50 (binding) | = 0.0000000042 M | Inhibitory activity against Dihydrofolate reductase of E. coli | ChEMBL. | 7035668 |
IC50 (binding) | = 0.0002 M | Inhibition of rat liver Dihydrofolate reductase. | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (binding) | = 3 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Staphylococcus aureus CN 491 | ChEMBL. | 7035668 |
Ratio (binding) | = 10 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Klebsiella pneumoniae CN 3632 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Escherichia coli CN 314 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Shigella dysentariae CN 1513 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Enterobacter aerogenes 2200/86 | ChEMBL. | 7035668 |
Ratio (binding) | = 30 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus mirabilis S 2409 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Salmonella typhi CN 512 | ChEMBL. | 7035668 |
Ratio (binding) | = 100 | Minimum inhibitory concentration versus trimethoprim against Dihydrofolate Reductase of Proteus vulgaris CN 329 | ChEMBL. | 7035668 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.