Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | dual specificity mitogen activated protein | 0.0833 | 1 | 1 |
Echinococcus granulosus | dual specificity mitogen activated protein | 0.0833 | 1 | 1 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0833 | 1 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0833 | 1 | 0.5 |
Loa Loa (eye worm) | STE/STE7/MEK7 protein kinase | 0.0833 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 217 ug kg-1 | In vivo beta adrenergic receptor blocking potency was determined by inhibition of tachycardia produced by isoproterenol (0.2 mg/kg iv) in cat preparation | ChEMBL. | 6128420 |
Inhibition (functional) | = 34 % | In vivo beta adrenergic receptor blocking potency was determined by inhibition of depressor response produced by isoproterenol (0.2 mg/kg iv) in cat preparation | ChEMBL. | 6128420 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.