Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | epidermal growth factor receptor | 0.00441448 | 0.014184 | 0.251609 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.00441448 | 0.014184 | 0.251609 |
Mycobacterium tuberculosis | Probable imidazole glycerol-phosphate dehydratase HisB | 0.142271 | 1 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.00433617 | 0.013624 | 0.241675 |
Echinococcus granulosus | insulin growth factor 1 receptor beta | 0.00970463 | 0.0520141 | 0.922672 |
Echinococcus granulosus | insulin receptor | 0.00970463 | 0.0520141 | 0.922672 |
Echinococcus multilocularis | insulin receptor | 0.00970463 | 0.0520141 | 0.922672 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.00357262 | 0.00816381 | 0.144817 |
Mycobacterium leprae | Probable imidazole glycerol-phosphate dehydratase HisB | 0.0704614 | 0.486488 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.00441448 | 0.014184 | 0.251609 |
Schistosoma mansoni | tyrosine kinase | 0.00441448 | 0.014184 | 0.251609 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.00970463 | 0.0520141 | 0.922672 |
Onchocerca volvulus | Bifunctional polynucleotide phosphatase\/kinase homolog | 0.0103142 | 0.0563733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00357262 | 0.00816381 | 0.0904729 |
Schistosoma mansoni | tyrosine kinase | 0.00441448 | 0.014184 | 0.251609 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.00329975 | 0.00621252 | 0.110203 |
Schistosoma mansoni | tyrosine kinase | 0.00441448 | 0.014184 | 0.251609 |
Plasmodium falciparum | bifunctional polynucleotide phosphatase/kinase | 0.0103142 | 0.0563733 | 0.5 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.00290202 | 0.00336828 | 0.035506 |
Echinococcus multilocularis | bifunctional polynucleotide | 0.0103142 | 0.0563733 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.00970463 | 0.0520141 | 0.922672 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0103142 | 0.0563733 | 0.5 |
Trypanosoma cruzi | polynucleotide kinase 3'-phosphatase, putative | 0.0103142 | 0.0563733 | 0.5 |
Plasmodium vivax | phosphatase, putative | 0.0103142 | 0.0563733 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.00529015 | 0.0204459 | 0.322189 |
Schistosoma mansoni | tyrosine kinase | 0.00433617 | 0.013624 | 0.241675 |
Brugia malayi | DNA 3'-phosphatase family protein | 0.0103142 | 0.0563733 | 1 |
Echinococcus granulosus | bifunctional polynucleotide | 0.0103142 | 0.0563733 | 1 |
Schistosoma mansoni | polynucleotide kinase-3'-phosphatase | 0.0103142 | 0.0563733 | 1 |
Plasmodium falciparum | phosphatase, putative | 0.0103142 | 0.0563733 | 0.5 |
Mycobacterium ulcerans | imidazoleglycerol-phosphate dehydratase | 0.142271 | 1 | 0.5 |
Plasmodium vivax | bifunctional polynucleotide phosphatase/kinase, putative | 0.0103142 | 0.0563733 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.00441448 | 0.014184 | 0.251609 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.00441448 | 0.014184 | 0.232312 |
Schistosoma mansoni | tyrosine kinase | 0.00970463 | 0.0520141 | 0.922672 |
Entamoeba histolytica | polynucleotide kinase-3-phosphatase, putative | 0.0103142 | 0.0563733 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.00441448 | 0.014184 | 0.251609 |
Trypanosoma cruzi | polynucleotide kinase 3'-phosphatase, putative | 0.0103142 | 0.0563733 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0103142 | 0.0563733 | 0.5 |
Brugia malayi | Protein kinase domain containing protein | 0.00970463 | 0.0520141 | 0.920678 |
Brugia malayi | Protein kinase domain containing protein | 0.00536846 | 0.0210059 | 0.356445 |
Loa Loa (eye worm) | hypothetical protein | 0.0103142 | 0.0563733 | 1 |
Echinococcus granulosus | metabotropic glutamate receptor 5 | 0.00357262 | 0.00816381 | 0.144817 |
Trypanosoma brucei | polynucleotide kinase 3'-phosphatase, putative | 0.0103142 | 0.0563733 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.00433617 | 0.013624 | 0.241675 |
Loa Loa (eye worm) | TK/INSR protein kinase | 0.00970463 | 0.0520141 | 0.917758 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.00441448 | 0.014184 | 0.204051 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 310 nM | in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4beta (stannyl methyl)trioxanes . | ChEMBL. | 9526569 |
IC50 (functional) | = 310 nM | in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4beta (stannyl methyl)trioxanes . | ChEMBL. | 9526569 |
IC50 (functional) | > 2500 nM | in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4alpha (alkylated)trioxanes | ChEMBL. | 9526569 |
IC50 (functional) | > 2500 nM | in vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54) in C4alpha (alkylated)trioxanes | ChEMBL. | 9526569 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 9526569 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.