Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.138112 | 0.679058 | 1 |
Brugia malayi | Matrixin family protein | 0.06227 | 0.289449 | 0.46757 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.034458 | 0.146575 | 0.491242 |
Loa Loa (eye worm) | hypothetical protein | 0.0074056 | 0.00760379 | 0.0111976 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0758417 | 0.359169 | 0.583232 |
Brugia malayi | Matrixin family protein | 0.06227 | 0.289449 | 0.46757 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.200587 | 1 | 1 |
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.0758417 | 0.359169 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.138112 | 0.679058 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00609135 | 0.000852342 | 0.00125518 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.06227 | 0.289449 | 0.996278 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0758417 | 0.359169 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00609135 | 0.000852342 | 0.00125518 |
Brugia malayi | Matrixin family protein | 0.06227 | 0.289449 | 0.46757 |
Loa Loa (eye worm) | hypothetical protein | 0.06227 | 0.289449 | 0.426251 |
Loa Loa (eye worm) | hypothetical protein | 0.06227 | 0.289449 | 0.426251 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.06227 | 0.289449 | 0.426251 |
Loa Loa (eye worm) | hypothetical protein | 0.00609135 | 0.000852342 | 0.00125518 |
Loa Loa (eye worm) | hypothetical protein | 0.0758417 | 0.359169 | 0.528922 |
Loa Loa (eye worm) | hypothetical protein | 0.0074056 | 0.00760379 | 0.0111976 |
Onchocerca volvulus | Matrilysin homolog | 0.138112 | 0.679058 | 1 |
Schistosoma mansoni | hypothetical protein | 0.062475 | 0.290502 | 1 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.200587 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.124745 | 0.610391 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.00609135 | 0.000852342 | 0.00125518 |
Loa Loa (eye worm) | hypothetical protein | 0.06227 | 0.289449 | 0.426251 |
Brugia malayi | Hemopexin family protein | 0.062475 | 0.290502 | 0.469317 |
Brugia malayi | Matrixin family protein | 0.06227 | 0.289449 | 0.46757 |
Loa Loa (eye worm) | hypothetical protein | 0.00609135 | 0.000852342 | 0.00125518 |
Mycobacterium ulcerans | hydrolase | 0.0758417 | 0.359169 | 1 |
Toxoplasma gondii | peptidase family M13 protein | 0.0074056 | 0.00760379 | 0.5 |
Onchocerca volvulus | 0.062475 | 0.290502 | 0.00270277 | |
Loa Loa (eye worm) | matrixin family protein | 0.124745 | 0.610391 | 0.89888 |
Loa Loa (eye worm) | hypothetical protein | 0.0074056 | 0.00760379 | 0.0111976 |
Loa Loa (eye worm) | hypothetical protein | 0.00609135 | 0.000852342 | 0.00125518 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 2.2 uM | Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum | ChEMBL. | 11300877 |
IC50 (functional) | = 2.2 uM | Antiplasmodial activity against chloroquine-resistant K1 strain of Plasmodium falciparum | ChEMBL. | 11300877 |
IC50 (functional) | = 6.5 uM | In vitro cell survival assay on cancer KB cell lines | ChEMBL. | 11300877 |
IC50 (functional) | = 23.8 uM | In vitro cytotoxicity against L6 cells | ChEMBL. | 11300877 |
IS (functional) | = 10.6 | Index of selectivity was determined in P. falciparum | ChEMBL. | 11300877 |
IS (functional) | = 10.6 | Index of selectivity was determined in P. falciparum | ChEMBL. | 11300877 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Plasmodium falciparum | ChEMBL23 | 11300877 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.