Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Human papillomavirus type 11 | Replication protein E1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus granulosus | enteropeptidase | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.005 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus granulosus | Peptidase S1 S6 chymotrypsin Hap | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus granulosus | subfamily S1A unassigned peptidase S01 family | 0.005 | 0 | 0.5 |
Brugia malayi | Trypsin-like protease protein 5 | 0.005 | 0 | 0.5 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Echinococcus multilocularis | transfer RNA-Gly | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Echinococcus granulosus | glycoprotein Antigen 5 | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Echinococcus granulosus | Mastin | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | aminopeptidase PILS (M01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Brugia malayi | Chymotrypsin-like protease CTRL-1 precursor | 0.005 | 0 | 0.5 |
Loa Loa (eye worm) | trypsin family protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | transfer RNA-Trp | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Echinococcus multilocularis | transfer RNA-Gly | 0.0052 | 1 | 1 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Onchocerca volvulus | 0.005 | 0 | 0.5 | |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.005 | 0 | 0.5 |
Brugia malayi | Trypsin family protein | 0.005 | 0 | 0.5 |
Echinococcus granulosus | transmembrane protease serine 3 | 0.005 | 0 | 0.5 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0 | 0.5 |
Echinococcus multilocularis | transfer RNA-Gly | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Echinococcus multilocularis | non capsid protein NS 1 | 0.0052 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.005 | 0 | 0.5 |
Schistosoma mansoni | cercarial elastase (S01 family) | 0.005 | 0 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 1.1 uM | Ability to inhibit in vitro ATPase activity of human papillomavirus (HPV6) E1 helicase | ChEMBL. | 14695816 |
IC50 (functional) | = 1.1 uM | Ability to inhibit in vitro ATPase activity of human papillomavirus (HPV6) E1 helicase | ChEMBL. | 14695816 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.