Detailed view for EmuJ_000031600

Basic information

TDR Targets ID: 957544
Echinococcus multilocularis, transfer RNA-Gly
Source Database / ID:  GeneDB

pI: 5.6649 | Length (AA): 272 | MW (Da): 30741 | Paralog Number: 34

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 0

Druggability Group : DG1

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00519   Papillomavirus helicase

Gene Ontology

Mouse over links to read term descriptions.
GO:0005524   ATP binding  
GO:0004003   ATP-dependent DNA helicase activity  
GO:0003677   DNA binding  
GO:0006260   DNA replication  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 2 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
9 272 2v9p (A) 324 577 19.00 0 0.99 1.11559 0.53
39 238 1u0j (A) 250 454 22.00 0 0.86 0.918294 0.13

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

No expression data available for this gene

Orthologs

Ortholog group members (OG5_182904)

Species Accession Gene Product
Echinococcus granulosus EgrG_002058200   5'partial|3'partial|non capsid protein NS 1
Echinococcus multilocularis EmuJ_000267000   transfer RNA-Trp
Echinococcus multilocularis EmuJ_000048500   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000000800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000007400   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000034800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000028000   transfer RNA-Gly
Echinococcus multilocularis EmuJ_000013800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000382800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000037400   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000368900   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000013900   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000027300   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000031600   transfer RNA-Gly
Echinococcus multilocularis EmuJ_000368200   transfer RNA-Gly
Echinococcus multilocularis EmuJ_000029800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000400700   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000031700   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000152800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000028700   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000369300   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000047600   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000050900   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000047700   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000030500   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000031900   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000048300   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000028900   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000368400   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000028800   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000388600   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000329200   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000368500   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000010700   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000048100   non capsid protein NS 1
Echinococcus multilocularis EmuJ_000383300   non capsid protein NS 1
Schistosoma mansoni Smp_194070   hypothetical protein

Essentiality

No essentiality data collected for this gene and/or its orthologs.

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Human papillomavirus type 11 Replication protein E1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0052 0.5 0.5
0.0052 0.7389 0.7389
0.0129 1 1
0.095 0.2797 0.2794
0.0219 0.86 1
0.0042 0.3088 0.3088
0.0052 1 1
0.0187 1 1
0.0052 1 1
0.0052 0.7389 0.7389
0.0731 0.2586 0.2586
0.0052 1 1
0.029 0.3347 0.3347
0.0304 1 1
0.029 0.3347 0.3347
0.0052 1 1
0.0052 0.7389 0.7389
0.0045 1 1
0.0052 0.5 0.5
0.0052 1 1
0.0129 0.2771 0.4361
0.0957 0.6928 0.6893
0.0052 1 1
0.029 0.3347 0.3347
0.0219 0.86 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier EmuJ_000031600 (Echinococcus multilocularis), transfer RNA-Gly
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