Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | protein C (inactivator of coagulation factors Va and VIIIa) | Starlite/ChEMBL | References |
Homo sapiens | plasminogen activator, tissue | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | protease, serine, 1 (trypsin 1) | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Trypsin family protein | protease, serine, 1 (trypsin 1) | 247 aa | 287 aa | 21.6 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0129 | 0.1695 | 1 | |
Schistosoma mansoni | membrane associated proteins in eicosanoid and glutathione metabolism family member | 0.0226 | 0.8835 | 0.8597 |
Brugia malayi | Trypsin family protein | 0.0129 | 0.1695 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1695 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0129 | 0.1695 | 0.5 |
Schistosoma mansoni | microsomal glutathione s-transferase | 0.0226 | 0.8835 | 0.8597 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0242 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0169 | 0.4631 | 0.3535 |
Toxoplasma gondii | MAPEG family protein | 0.0226 | 0.8835 | 0.5 |
Schistosoma mansoni | lipoxygenase | 0.0242 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 10 nM | In vitro inhibitory activity against coagulation factor X. | ChEMBL. | 15013007 |
IC50 (binding) | = 10 nM | In vitro inhibitory activity against coagulation factor X. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against thrombin. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against tissue type plasminogen activator. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against trypsin. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against activated protein C | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against plasmin. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against thrombin. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against tissue type plasminogen activator. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against trypsin. | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against activated protein C | ChEMBL. | 15013007 |
IC50 (binding) | > 11 uM | Inhibitory activity against plasmin. | ChEMBL. | 15013007 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.