Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | phenylethanolamine N-methyltransferase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | NNMT/PNMT/TEMT family protein | phenylethanolamine N-methyltransferase | 282 aa | 257 aa | 26.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Toxoplasma gondii | kringle domain-containing protein | 0.0056 | 0 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0056 | 0 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0056 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.0038 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0 | 0.5 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0084 | 0.0992 | 0.0992 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0084 | 0.0992 | 0.0992 |
Onchocerca volvulus | 0.0056 | 0 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0084 | 0.0992 | 0.0992 |
Giardia lamblia | DNA repair protein RAD52 | 0.0304 | 0.8959 | 0.5 |
Loa Loa (eye worm) | NNMT/PNMT/TEMT family protein | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0333 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.0038 | 0.0038 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0057 | 0.0038 | 0.0038 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0056 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0056 | 0 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0056 | 0 | 0.5 |
Entamoeba histolytica | DNA repair and recombination protein RAD52, putative | 0.0304 | 0.8959 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0084 | 0.0992 | 0.0992 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 0.099 uM | In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMet | ChEMBL. | 15771426 |
Ki (binding) | = 0.099 uM | In vitro binding affinity against recombinant human Phenylethanolamine N-methyltransferase expressed in E. coli using [methyl-3H]-AdoMet | ChEMBL. | 15771426 |
Ki (binding) | = 670 uM | In vitro binding affinity against rat Alpha-2 adrenergic receptor using [3H]-clonidine | ChEMBL. | 15771426 |
Ki (binding) | = 670 uM | In vitro binding affinity against rat Alpha-2 adrenergic receptor using [3H]-clonidine | ChEMBL. | 15771426 |
Selectivity (binding) | = 6800 | Ratio of affinity for Alpha-2 adrenergic receptor to that of Phenylethanolamine N-methyltransferase | ChEMBL. | 15771426 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.