Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | transient receptor potential ion channel A | 0.0091 | 0.9496 | 0.9469 |
Echinococcus multilocularis | transient receptor potential ion channel A | 0.0091 | 0.9496 | 0.9469 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.808 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.808 | 0.7978 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0504 | 0.0504 |
Schistosoma mansoni | transient receptor potential channel 4 | 0.0094 | 1 | 1 |
Schistosoma mansoni | transient receptor potential channel | 0.0094 | 1 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.808 | 0.7978 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.808 | 0.808 |
Loa Loa (eye worm) | hypothetical protein | 0.0059 | 0.4377 | 0.4377 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0062 | 0.4881 | 0.4609 |
Echinococcus multilocularis | transient receptor potential gamma protein | 0.0094 | 1 | 1 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.808 | 0.7978 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0062 | 0.4881 | 0.4609 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.808 | 0.6249 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.808 | 0.808 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.808 | 0.808 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.808 | 0.7978 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.808 | 0.7978 |
Echinococcus multilocularis | short transient receptor potential channel 6 | 0.0062 | 0.4881 | 0.4609 |
Echinococcus granulosus | short transient receptor potential channel 6 | 0.0062 | 0.4881 | 0.4609 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.808 | 0.7978 |
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.808 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.808 | 0.808 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.62 uM | In vitro inhibitory activity against acetylcholinesterase | ChEMBL. | 10230623 |
IC50 (binding) | = 1.41 uM | In vitro inhibitory activity against Butyrylcholinesterase | ChEMBL. | 10230623 |
IC50 (binding) | = 1.41 uM | In vitro inhibitory activity against Butyrylcholinesterase | ChEMBL. | 10230623 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.