Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 1 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Brugia malayi | Type I phosphodiesterase / nucleotide pyrophosphatase family protein | 0.0035 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0928 | 0.0928 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.0928 | 0.0928 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.0928 | 0.0928 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.0928 | 0.0928 |
Schistosoma mansoni | ectonucleotide pyrophosphatase/phosphodiesterase | 0.0035 | 0.0928 | 0.0928 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0928 | 0.0928 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0928 | 0.0928 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Echinococcus multilocularis | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Onchocerca volvulus | 0.0035 | 0.0928 | 0.0928 | |
Onchocerca volvulus | 0.0075 | 1 | 1 | |
Loa Loa (eye worm) | thrombospondin type 1 domain-containing protein | 0.0075 | 1 | 1 |
Onchocerca volvulus | 0.0035 | 0.0928 | 0.0928 | |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Echinococcus granulosus | ectonucleotide pyrophosphatase:phosphodiesterase | 0.0035 | 0.0928 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | > 500 uM | Cytotoxicity of the compound against sensitive L1210 murine leukemia cells by MTT assay | ChEMBL. | 14695835 |
IC50 (functional) | > 500 uM | Cytotoxicity of the compound against multidrug resistant (MDR) L1210 murine leukemia cells by MTT assay | ChEMBL. | 14695835 |
IC50 (functional) | > 500 uM | Cytotoxicity of the compound against multidrug resistant (MDR) human myeloma 8226 cells by MTT assay | ChEMBL. | 14695835 |
IC50 (functional) | > 500 uM | Cytotoxicity of the compound against sensitive L1210 murine leukemia cells by MTT assay | ChEMBL. | 14695835 |
IC50 (functional) | > 500 uM | Cytotoxicity of the compound against multidrug resistant (MDR) L1210 murine leukemia cells by MTT assay | ChEMBL. | 14695835 |
IC50 (functional) | > 500 uM | Cytotoxicity of the compound against multidrug resistant (MDR) human myeloma 8226 cells by MTT assay | ChEMBL. | 14695835 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.