Detailed information for compound 310038

Basic information

Technical information
  • TDR Targets ID: 310038
  • Name: 2-[4-[3-(benzylcarbamoyl)phenyl]phenyl]sulfon ylacetic acid
  • MW: 409.455 | Formula: C22H19NO5S
  • H donors: 2 H acceptors: 5 LogP: 3.15 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)CS(=O)(=O)c1ccc(cc1)c1cccc(c1)C(=O)NCc1ccccc1
  • InChi: 1S/C22H19NO5S/c24-21(25)15-29(27,28)20-11-9-17(10-12-20)18-7-4-8-19(13-18)22(26)23-14-16-5-2-1-3-6-16/h1-13H,14-15H2,(H,23,26)(H,24,25)
  • InChiKey: ZYTZNZMCXIQUIG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 2-[4-[3-[(benzylamino)-oxomethyl]phenyl]phenyl]sulfonylacetic acid
  • 2-[4-[3-(phenylmethylcarbamoyl)phenyl]phenyl]sulfonylethanoic acid
  • 2-[4-[3-(phenylmethylcarbamoyl)phenyl]phenyl]sulfonylacetic acid
  • 2-[4-[3-[oxo-(phenylmethylamino)methyl]phenyl]phenyl]sulfonylacetic acid
  • AIDS-191244
  • AIDS191244
  • Acetic acid, [[3'-[[(phenylmethyl)amino]carbonyl][1,1'-biphenyl]-4-yl]sulfonyl]-

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Human papillomavirus type 11 Replication protein E1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis transfer RNA-Gly Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Schistosoma mansoni hypothetical protein Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis transfer RNA-Gly Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis transfer RNA-Gly Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus granulosus 5'partial|3'partial|non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis non capsid protein NS 1 Get druggable targets OG5_182904 All targets in OG5_182904
Echinococcus multilocularis transfer RNA-Trp Get druggable targets OG5_182904 All targets in OG5_182904
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0029 0.2905 1
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.2905 1
Brugia malayi sulfakinin receptor protein 0.0029 0.2905 1
Schistosoma mansoni biogenic amine receptor 0.0029 0.2905 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0029 0.2905 0.1378
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.2905 0.1378
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.0029 0.2905 1
Schistosoma mansoni amine GPCR 0.0029 0.2905 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.2456 0.5
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.2905 1
Schistosoma mansoni opsin-like receptor 0.0029 0.2905 1
Schistosoma mansoni opsin-like receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.2456 0.8248
Echinococcus granulosus neuropeptide receptor 0.0029 0.2905 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Echinococcus multilocularis g-protein coupled receptor 0.0029 0.2905 0.1378
Brugia malayi AKH receptor 0.0029 0.2905 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Brugia malayi Dopamine receptor protein 1 0.0029 0.2905 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Echinococcus granulosus somatostatin receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis serotonin receptor 0.0029 0.2905 0.1378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Schistosoma mansoni alpha-1 adrenergic receptor 0.0029 0.2905 1
Mycobacterium ulcerans hypothetical protein 0.0027 0.2456 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Schistosoma mansoni adenoreceptor 0.0029 0.2905 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0029 0.2905 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Schistosoma mansoni neuropeptide receptor 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.2905 1
Brugia malayi Serotonin receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Brugia malayi neuropeptide F receptor 0.0029 0.2905 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Echinococcus multilocularis g protein coupled receptor 0.0029 0.2905 0.1378
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0029 0.2905 0.1378
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0341 0.5
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Brugia malayi Dopamine receptor protein 2 0.0029 0.2905 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Schistosoma mansoni amine GPCR 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0029 0.2905 1
Echinococcus multilocularis g protein coupled receptor 0.0029 0.2905 0.1378
Schistosoma mansoni neuropeptide receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.2456 0.8248
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.2456 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.0029 0.2905 0.1378
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0029 0.2905 0.1378
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0029 0.2905 1
Schistosoma mansoni neuropeptide receptor 0.0029 0.2905 1
Echinococcus multilocularis transfer RNA-Trp 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Loa Loa (eye worm) TYRA-2 protein 0.0029 0.2905 1
Schistosoma mansoni amine GPCR 0.0029 0.2905 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.2456 1
Echinococcus multilocularis allatostatin A receptor 0.0029 0.2905 0.1378
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.2456 0.5
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0029 0.2905 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.2905 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Onchocerca volvulus 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Brugia malayi putative neuropeptide receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.2905 0.1378
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Echinococcus multilocularis neuropeptide receptor A26 0.0029 0.2905 0.1378
Loa Loa (eye worm) neuropeptide F receptor 0.0029 0.2905 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.2905 0.1378
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.2905 1
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Brugia malayi Melatonin receptor type 1A 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Brugia malayi larval opioid receptor 0.0029 0.2905 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Brugia malayi Dopamine receptor 0.0029 0.2905 1
Echinococcus multilocularis transfer RNA-Gly 0.0052 1 1
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0029 0.2905 0.1378
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Brugia malayi Tachykinin-like peptides receptor 99D 0.0029 0.2905 1
Schistosoma mansoni biogenic amine receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.2456 0.5
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.2905 0.1378
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus multilocularis fmrfamide receptor 0.0029 0.2905 0.1378
Echinococcus multilocularis neuropeptide FF receptor 2 0.0029 0.2905 0.1378
Brugia malayi hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus g protein coupled receptor 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Schistosoma mansoni myosin xvIII 0.0029 0.2905 1
Schistosoma mansoni hypothetical protein 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Schistosoma mansoni amine GPCR 0.0029 0.2905 1
Echinococcus multilocularis fmrfamide receptor 0.0029 0.2905 0.1378
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Schistosoma mansoni neuropeptide f receptor 76f 0.0029 0.2905 1
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0029 0.2905 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.2456 1
Brugia malayi follicle stimulating hormone receptor 0.0029 0.2905 1
Echinococcus granulosus g-protein coupled receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Schistosoma mansoni opsin-like receptor 0.0029 0.2905 1
Echinococcus granulosus 7tm_1 domain containing protein 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Loa Loa (eye worm) melatonin receptor type 1A 0.0029 0.2905 1
Brugia malayi G protein-coupled receptor 0.0029 0.2905 1
Schistosoma mansoni hypothetical protein 0.0029 0.2905 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Echinococcus granulosus neuropeptide s receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0029 0.2905 0.1378
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0029 0.2905 1
Echinococcus multilocularis transfer RNA-Gly 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus granulosus 7TM GPCR rhodopsin 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus neuropeptide FF receptor 2 0.0029 0.2905 1
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.2905 1
Echinococcus granulosus peptide allatostatin:somatostatin 0.0029 0.2905 1
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0341 0.5
Echinococcus granulosus neuropeptide Y receptor 0.0029 0.2905 1
Echinococcus multilocularis transfer RNA-Gly 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.2905 0.1378
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0029 0.2905 0.1378
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.002 0.0341 0.5
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus granulosus g protein coupled receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Schistosoma mansoni amine GPCR 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus granulosus biogenic amine 5HT receptor 0.0029 0.2905 1
Entamoeba histolytica acyl-CoA synthetase, putative 0.0027 0.2456 0.5
Echinococcus granulosus serotonin receptor 0.0029 0.2905 1
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0029 0.2905 0.1378
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0029 0.2905 1
Echinococcus multilocularis neuropeptides capa receptor 0.0029 0.2905 0.1378
Schistosoma mansoni histamine h1 receptor 0.0029 0.2905 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Schistosoma mansoni hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Schistosoma mansoni biogenic amine receptor 0.0029 0.2905 1
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0029 0.2905 0.1378
Brugia malayi putative neuropeptide receptor NPR1 0.0029 0.2905 1
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) G-protein coupled receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus allatostatin A receptor 0.0029 0.2905 1
Echinococcus granulosus neuropeptides capa receptor 0.0029 0.2905 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus multilocularis neuropeptide Y receptor 0.0029 0.2905 0.1378
Echinococcus granulosus orexin receptor type 2 0.0029 0.2905 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Brugia malayi Serotonin receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0027 0.2456 0.8248
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0029 0.2905 1
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0029 0.2905 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Echinococcus granulosus alpha 1A adrenergic receptor 0.0029 0.2905 1
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0029 0.2905 0.1378
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0029 0.2905 1
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.2456 0.5
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.2456 0.5
Echinococcus multilocularis neuropeptide receptor 0.0029 0.2905 0.1378
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.2456 1
Echinococcus multilocularis G protein coupled receptor 139 0.0029 0.2905 0.1378
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis somatostatin receptor 0.0029 0.2905 0.1378
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0029 0.2905 0.1378
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0029 0.2905 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.2456 1
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0029 0.2905 1
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0029 0.2905 1
Schistosoma mansoni hypothetical protein 0.0029 0.2905 1
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0341 0.139
Echinococcus multilocularis g protein coupled receptor 0.0029 0.2905 0.1378
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.2456 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus granulosus neuropeptide receptor 0.0029 0.2905 1
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0029 0.2905 1
Echinococcus granulosus fmrfamide receptor 0.0029 0.2905 1
Echinococcus multilocularis neuropeptide s receptor 0.0029 0.2905 0.1378
Onchocerca volvulus 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0029 0.2905 1
Echinococcus granulosus sex peptide receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis dro:myosuppressin receptor 0.0029 0.2905 0.1378
Brugia malayi GnHR receptor homolog 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.2456 1
Echinococcus multilocularis orexin receptor type 2 0.0029 0.2905 0.1378
Brugia malayi hypothetical protein 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Onchocerca volvulus Neuropeptide F receptor homolog 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus multilocularis sex peptide receptor 0.0029 0.2905 0.1378
Schistosoma mansoni neuropeptide F-like receptor 0.0029 0.2905 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.2456 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus multilocularis neuropeptide receptor 0.0029 0.2905 0.1378
Brugia malayi G-protein coupled receptor 0.0029 0.2905 1
Brugia malayi RE15519p 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus granulosus tm gpcr rhodopsin 0.0029 0.2905 1
Echinococcus multilocularis serotonin receptor 0.0029 0.2905 0.1378
Echinococcus granulosus hypothetical protein 0.0029 0.2905 1
Onchocerca volvulus 0.0029 0.2905 1
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0029 0.2905 1
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0029 0.2905 1
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0027 0.2456 0.5
Brugia malayi ORL1-like opioid receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.2456 1
Brugia malayi G protein-coupled receptor F59B2.13 0.0029 0.2905 1
Brugia malayi neuropeptide F receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0029 0.2905 1
Echinococcus granulosus g protein coupled receptor 0.0029 0.2905 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Schistosoma mansoni growth hormone secretagogue receptor 0.0029 0.2905 1
Brugia malayi hypothetical protein 0.0029 0.2905 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0029 0.2905 1
Schistosoma mansoni neuropeptide receptor 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Echinococcus granulosus neuropeptide receptor A26 0.0029 0.2905 1
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0029 0.2905 0.1378
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0029 0.2905 1
Loa Loa (eye worm) hypothetical protein 0.0029 0.2905 1
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0029 0.2905 1
Echinococcus granulosus G protein coupled receptor 139 0.0029 0.2905 1
Echinococcus multilocularis non capsid protein NS 1 0.0052 1 1
Entamoeba histolytica acyl-coA synthetase, putative 0.0027 0.2456 0.5
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0029 0.2905 0.1378
Brugia malayi G-protein coupled receptor 0.0029 0.2905 1

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.087 uM Ability to inhibit in vitro ATPase activity of human papillomavirus (HPV6) E1 helicase ChEMBL. 14695816
IC50 (functional) = 0.087 uM Ability to inhibit in vitro ATPase activity of human papillomavirus (HPV6) E1 helicase ChEMBL. 14695816

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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