Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | oxytocin receptor | Starlite/ChEMBL | References |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Clearance (ADMET) | = 33 ml min-1 kg-1 | Plasma clearance of the compound was determined | ChEMBL. | 11392542 |
clogP | = 4.9 | Calculated partition coefficient (clogP) | ChEMBL. | 11392542 |
Ki (binding) | = -7.4 | Inhibition of binding of [3H]-oxytocin with human oxytocin receptor | ChEMBL. | 11392542 |
Log Ki (binding) | = 7.4 | Inhibition of binding of [3H]-oxytocin with human oxytocin receptor | ChEMBL. | 11392542 |
T1/2 (ADMET) | = 1.9 | Half life of the compound (iv) of the compound was determined | ChEMBL. | 11392542 |
Vd (ADMET) | = 2.8 l kg-1 | Volume distribution of the compound was determined | ChEMBL. | 11392542 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.