Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | Presenilin enhancer-2 subunit of gamma secretase, putative | 0.0056 | 0.2169 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0033 | 0.0782 | 0.0782 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0053 | 0.1983 | 0.9322 |
Trypanosoma cruzi | calpain cysteine peptidase, putative | 0.002 | 0 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0056 | 0.2169 | 1 |
Echinococcus multilocularis | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.2127 | 0.2127 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0047 | 0.1622 | 0.1622 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0 | 0.5 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.2127 | 1 |
Trypanosoma cruzi | cysteine peptidase, Clan CA, family C2, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1983 | 0.1983 |
Plasmodium vivax | subtilisin-like protease 1 | 0.0176 | 0.931 | 1 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.1983 | 0.1983 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0039 | 0.1143 | 0.1143 |
Schistosoma mansoni | family C2 unassigned peptidase (C02 family) | 0.0056 | 0.2127 | 1 |
Echinococcus granulosus | presenilin enhancer 2 | 0.0187 | 1 | 1 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0 | 0.5 |
Echinococcus multilocularis | calpain family protein 1, d | 0.0039 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | hypothetical protein | 0.0039 | 0.1143 | 0.1143 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0 | 0.5 |
Onchocerca volvulus | 0.0033 | 0.0782 | 0.5 | |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | gamma-secretase subunit pen-2 | 0.0187 | 1 | 1 |
Toxoplasma gondii | subtilisin SUB1 | 0.0176 | 0.931 | 1 |
Plasmodium falciparum | subtilisin-like protease 1 | 0.0176 | 0.931 | 0.5 |
Echinococcus multilocularis | presenilin enhancer 2 | 0.0187 | 1 | 1 |
Echinococcus multilocularis | calpain A | 0.0056 | 0.2127 | 0.2127 |
Echinococcus granulosus | calpain A | 0.0056 | 0.2127 | 0.2127 |
Brugia malayi | calpain family protein 1 | 0.0053 | 0.1983 | 0.1983 |
Echinococcus granulosus | family C2 unassigned peptidase C02 family | 0.0056 | 0.2127 | 0.2127 |
Trypanosoma cruzi | calpain-like cysteine peptidase, putative | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | calpain family protein 1 | 0.0053 | 0.1983 | 0.1983 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | 0 | Inhibitory concentration of the compound against Mycobacterium tuberculosis in vero cells; Not determined | ChEMBL. | 14695841 |
Inhibition (functional) | = 0 % | Percent inhibitory activity against Mycobacterium tuberculosis H37Rv Strain at 6.25 ug/mL | ChEMBL. | 14695841 |
Inhibition (functional) | = 0 % | Percent inhibitory activity against Mycobacterium tuberculosis H37Rv Strain at 6.25 ug/mL | ChEMBL. | 14695841 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity of the compound against growth of Mycobacterium tuberculosis (Mtb) H37Ra Strain | ChEMBL. | 14695841 |
MIC (functional) | = 16 ug ml-1 | Inhibitory activity of the compound against growth of Mycobacterium tuberculosis (Mtb) H37Ra Strain | ChEMBL. | 14695841 |
MIC90 (functional) | > 6.25 ug ml-1 | Inhibitory activity against growth of Mycobacterium tuberculosis H37Rv Strain | ChEMBL. | 14695841 |
MIC90 (functional) | > 6.25 ug ml-1 | Inhibitory activity against growth of Mycobacterium tuberculosis H37Rv Strain | ChEMBL. | 14695841 |
SI (functional) | 0 | Selective index was measured as the ratio of MIC and IC50; nd = not determined | ChEMBL. | 14695841 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.