Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | thymidine phosphorylase | Starlite/ChEMBL | References |
Escherichia coli | thymidine phosphorylase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Echinococcus granulosus | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Mycobacterium ulcerans | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Echinococcus multilocularis | thymidine phosphorylase | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | Get druggable targets OG5_131632 | All targets in OG5_131632 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0153 | 0.0086 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.005 | 0.0252 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0153 | 0.0175 |
Echinococcus multilocularis | thymidine phosphorylase | 0.1531 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0153 | 0.2342 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0076 | 0.0422 | 0.6456 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.005 | 0.0252 | 0.0378 |
Schistosoma mansoni | hypothetical protein | 0.0076 | 0.0422 | 0.0729 |
Onchocerca volvulus | 0.0022 | 0.0068 | 0.5 | |
Mycobacterium tuberculosis | Probable thymidine phosphorylase DeoA (tdrpase) (pyrimidine phosphorylase) | 0.1531 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0153 | 0.0175 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0035 | 0.0153 | 0.2342 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0065 | 0.1001 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0422 | 0.6456 |
Echinococcus multilocularis | neuropeptide receptor A26 | 0.0517 | 0.3322 | 0.3276 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0153 | 0.0175 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0111 | 0.0653 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0022 | 0.0068 | 0.1042 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0759 | 0.4918 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0153 | 0.0175 |
Brugia malayi | intermediate filament protein | 0.0022 | 0.0068 | 0.1042 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0232 | 0.1447 | 0.1389 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.005 | 0.0252 | 0.5 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0035 | 0.0153 | 0.2342 |
Echinococcus granulosus | neuropeptide s receptor | 0.0517 | 0.3322 | 0.3276 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0232 | 0.1447 | 0.1389 |
Mycobacterium leprae | Probable anthranilate phosphoribosyltransferase TrpD | 0.0432 | 0.2766 | 0.5 |
Loa Loa (eye worm) | intermediate filament protein | 0.0022 | 0.0068 | 0.1042 |
Mycobacterium ulcerans | thymidine phosphorylase | 0.1531 | 1 | 1 |
Echinococcus granulosus | neuropeptide receptor A26 | 0.0517 | 0.3322 | 0.3276 |
Echinococcus multilocularis | atpase aaa+ type core atpase aaa type core | 0.0916 | 0.5954 | 0.5926 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0759 | 0.4918 | 0.4883 |
Echinococcus multilocularis | GPCR, family 2 | 0.0035 | 0.0153 | 0.0086 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0022 | 0.0068 | 0.1042 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0153 | 0.0086 |
Mycobacterium ulcerans | anthranilate phosphoribosyltransferase | 0.0432 | 0.2766 | 0.258 |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.005 | 0.0252 | 0.0185 |
Mycobacterium tuberculosis | Probable anthranilate phosphoribosyltransferase TrpD | 0.0432 | 0.2766 | 0.258 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0035 | 0.0153 | 0.0086 |
Onchocerca volvulus | 0.0022 | 0.0068 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.0653 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0759 | 0.4918 | 0.4883 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.005 | 0.0252 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0111 | 0.0653 | 1 |
Echinococcus granulosus | GPCR family 2 | 0.0035 | 0.0153 | 0.0086 |
Echinococcus granulosus | aldehyde dehydrogenase mitochondrial | 0.005 | 0.0252 | 0.0185 |
Echinococcus multilocularis | neuropeptide s receptor | 0.0517 | 0.3322 | 0.3276 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0035 | 0.0153 | 0.2342 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0022 | 0.0068 | 0.1042 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0111 | 0.0653 | 1 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0035 | 0.0153 | 0.0086 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 7.3 uM | Inhibition of [3H]methylthymidine binding to human recombinant thymidine phosphorylase expressed in chinese hamster V79 cells after 20 mins by scintillation counting | ChEMBL. | 21195612 |
IC50 (binding) | = 11.4 uM | Inhibition of [3H]methylthymidine binding to Escherichia coli thymidine phosphorylase after 20 mins by scintillation counting | ChEMBL. | 21195612 |
IC50 (binding) | = 15.1 uM | Inhibition of [3H]methylthymidine binding to human placenta thymidine phosphorylase after 20 mins by scintillation counting | ChEMBL. | 21195612 |
Inhibition (binding) | = 31 % | Inhibition of E. coli TPase at a concentration of 20 microM after 60 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 31 % | Inhibition of E. coli TPase at a concentration of 20 microM after 60 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 38 % | Inhibition of E. coli TPase at a concentration of 20 microM after 40 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 38 % | Inhibition of E. coli TPase at a concentration of 20 microM after 40 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 48 % | Inhibition of E. coli TPase at a concentration of 20 microM after 20 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 48 % | Inhibition of E. coli TPase at a concentration of 20 microM after 20 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 48 % | Inhibition of [3H]methylthymidine binding to Escherichia coli thymidine phosphorylase at 20 uM after 20 mins by scintillation counting | ChEMBL. | 21195612 |
Inhibition (binding) | = 72 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 100 microM after 60 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 72 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 100 microM after 60 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 77 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 100 microM after 40 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 77 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 100 microM after 40 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 83 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 100 microM after 20 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 83 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 100 microM after 20 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 83 % | Inhibition of [3H]methylthymidine binding to Escherichia coli thymidine phosphorylase at 100 uM after 20 mins by scintillation counting | ChEMBL. | 21195612 |
Inhibition (binding) | = 94 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 1000 microM after 60 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 94 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 1000 microM after 60 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 96 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 1000 microM after 40 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 96 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 1000 microM after 40 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 97 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 1000 microM after 20 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 97 % | Inhibition of E. coli Thymidine Phosphorylase at a concentration of 1000 microM after 20 minutes | ChEMBL. | 10715161 |
Inhibition (binding) | = 97 % | Inhibition of [3H]methylthymidine binding to Escherichia coli thymidine phosphorylase at 1000 uM after 20 mins by scintillation counting | ChEMBL. | 21195612 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.