Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Dihydrofolate reductase | Starlite/ChEMBL | References |
Candida albicans | dihydrofolate reductase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus granulosus | dihydrofolate reductase | 0.0415 | 1 | 1 |
Onchocerca volvulus | Purine nucleoside phosphorylase homolog | 0.0282 | 0.3049 | 0.5 |
Mycobacterium leprae | DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) | 0.0415 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Chlamydia trachomatis | dihydrofolate reductase | 0.0415 | 1 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Loa Loa (eye worm) | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus multilocularis | dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Giardia lamblia | Purine nucleoside phosphorylase lateral transfer candidate | 0.0282 | 0.3049 | 0.5 |
Mycobacterium tuberculosis | Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) | 0.0415 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Mycobacterium ulcerans | dihydrofolate reductase DfrA | 0.0415 | 1 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Brugia malayi | Dihydrofolate reductase | 0.0415 | 1 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0282 | 0.3049 | 0.3049 |
Trichomonas vaginalis | purine nucleoside phosphorylase I, putative | 0.0282 | 0.3049 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
I50 (binding) | = 0.17 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Escherichia coli | ChEMBL. | 14695838 |
I50 (binding) | = 0.43 uM l-1 | Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans | ChEMBL. | 14695838 |
I50 (binding) | = 1.01 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu | ChEMBL. | 14695838 |
I50 (binding) | = 2.63 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate reductase (DHFR) from rat | ChEMBL. | 14695838 |
IC50 (binding) | = 0.17 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Escherichia coli | ChEMBL. | 14695838 |
IC50 (binding) | = 0.4300000000000001 uM l-1 | Inhibitory activity against cell free dihydrofolate reductase (DHFR) from Candida albicans | ChEMBL. | 14695838 |
IC50 (binding) | = 1.01 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate redutase (DHFR) from Mycobacterium lufu | ChEMBL. | 14695838 |
IC50 (binding) | = 2.63 uM l-1 | Inhibitory activity of the compound against cell free dihydrofolate reductase (DHFR) from rat | ChEMBL. | 14695838 |
MIC (functional) | = 16 ug ml-1 | Inhibitory effect of the compound on Candida glabrata YEM75 WT Strain | ChEMBL. | 14695838 |
MIC (functional) | = 16 ug ml-1 | Inhibitory effect of the compound on Candida glabrata YEM216 pCDR1pCDR2pBEN YEM75 WT Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM12 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM27 quad deletion Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM12 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 32 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM27 quad deletion Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM13 BENup Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM14 Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM15 CDR1CDR2up Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM30 Strain | ChEMBL. | 14695838 |
MIC (functional) | = 64 ug ml-1 | Inhibitory effect of the compound on Candida glabrata YEM88 CgCDR1 CgCDR2up Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM13 BENup Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM14 Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans YEM15 CDR1CDR2up Strain | ChEMBL. | 14695838 |
MIC (functional) | > 64 ug ml-1 | Inhibitory effect of the compound on Candida albicans wild type YEM30 Strain | ChEMBL. | 14695838 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.