Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Hepatitis C virus | Hepatitis C virus NS5B RNA-dependent RNA polymerase | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Peroxidasin | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0298 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0298 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0298 | 0.5 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0298 | 0.5 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0298 | 0.5 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0298 | 0.5 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0298 | 0.5 | 0.5 |
Onchocerca volvulus | 0.0298 | 0.5 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0298 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 5.9 uM | Inhibitory activity against NS5B polymerase of hepatitis C virus | ChEMBL. | 14684311 |
IC50 (binding) | = 5.9 uM | Inhibitory activity against NS5B polymerase of hepatitis C virus | ChEMBL. | 14684311 |
IC50 (binding) | > 500 uM | Inhibitory activity against polio virus RNA polymerase | ChEMBL. | 14684311 |
IC50 (binding) | > 500 uM | Inhibitory activity against calf thymus RNA polymerase | ChEMBL. | 14684311 |
IC50 (binding) | > 500 uM | Inhibitory activity against polio virus RNA polymerase | ChEMBL. | 14684311 |
IC50 (binding) | > 500 uM | Inhibitory activity against calf thymus RNA polymerase | ChEMBL. | 14684311 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.