Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus multilocularis | serotonin receptor | 5-hydroxytryptamine (serotonin) receptor 1F, G protein-coupled | 366 aa | 399 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.033 | 0.3121 | 0.1475 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein (hisJ) | 0.0202 | 0 | 0.5 |
Chlamydia trachomatis | glutamine binding protein | 0.0202 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.037 | 0.411 | 0.2701 |
Echinococcus granulosus | nmda type glutamate receptor | 0.037 | 0.411 | 0.1439 |
Mycobacterium tuberculosis | Probable glutamine-binding lipoprotein GlnH (GLNBP) | 0.0202 | 0 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0531 | 0.8034 | 0.5 |
Treponema pallidum | amino acid ABC transporter, periplasmic binding protein | 0.0202 | 0 | 0.5 |
Mycobacterium ulcerans | glutamine-binding lipoprotein GlnH | 0.0202 | 0 | 0.5 |
Chlamydia trachomatis | arginine ABC transporter substrate-binding protein ArtJ | 0.0202 | 0 | 0.5 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0611 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 68.7 nM | Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor | ChEMBL. | 14684321 |
EC50 (functional) | = 68.7 nM | Concentration required for stimulation of [35S]-GTP-gammaS, binding in mouse LM(tk-1) cells expressing the human 5-hydroxytryptamine 1F receptor | ChEMBL. | 14684321 |
Emax (functional) | = 87 % | Maximum stimulation of [35S]-GTP-gammaS, binding expressed relative to the maximal effect of 5-hydroxytryptamine | ChEMBL. | 14684321 |
Emax (functional) | = 87 % | Maximum stimulation of [35S]-GTP-gammaS, binding expressed relative to the maximal effect of 5-hydroxytryptamine | ChEMBL. | 14684321 |
Ki (binding) | = 2.9 nM | In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor | ChEMBL. | 14684321 |
Ki (binding) | = 2.9 nM | In vitro binding affinity of the compound for human 5-hydroxytryptamine 1F receptor | ChEMBL. | 14684321 |
Selectivity ratio (binding) | = 31 | Ratio of the Ki value for human 5-HT1D receptor versus human 5-HT1F receptor | ChEMBL. | 14684321 |
Selectivity ratio (binding) | = 103 | Ratio of the Ki value for human 5-HT1A receptor versus human 5-HT1F receptor | ChEMBL. | 14684321 |
Selectivity ratio (binding) | = 164 | Ratio of the Ki value for human 5-HT1B receptor versus human 5-HT1F receptor | ChEMBL. | 14684321 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.