Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | Curated by TDR Targets | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | integrin alpha | 0.048 | 0.5927 | 1 |
Echinococcus multilocularis | integrin alpha ps | 0.0215 | 0.1777 | 0.2851 |
Echinococcus multilocularis | thymidylate synthase | 0.013 | 0.0438 | 0.0676 |
Mycobacterium ulcerans | thymidylate synthase | 0.013 | 0.0438 | 0.5 |
Echinococcus multilocularis | integrin alpha 3 | 0.0368 | 0.4171 | 0.6738 |
Echinococcus granulosus | integrin alpha 3 | 0.0368 | 0.4171 | 0.6738 |
Trypanosoma brucei | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1267 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0496 | 0.618 | 1 |
Trypanosoma cruzi | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0265 | 0.2555 | 0.2555 |
Schistosoma mansoni | bifunctional dihydrofolate reductase-thymidylate synthase | 0.013 | 0.0438 | 0.0705 |
Loa Loa (eye worm) | hypothetical protein | 0.0103 | 0.0022 | 0.0022 |
Brugia malayi | thymidylate synthase | 0.013 | 0.0438 | 0.0492 |
Leishmania major | dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1267 | 0.5 |
Loa Loa (eye worm) | thymidylate synthase | 0.013 | 0.0438 | 0.0438 |
Echinococcus granulosus | integrin alpha ps | 0.0215 | 0.1777 | 0.2851 |
Mycobacterium tuberculosis | Probable thymidylate synthase ThyA (ts) (TSASE) | 0.013 | 0.0438 | 0.5 |
Schistosoma mansoni | integrin alpha-ps | 0.0215 | 0.1777 | 0.2973 |
Echinococcus multilocularis | integrin alpha ps | 0.0215 | 0.1777 | 0.2851 |
Schistosoma mansoni | integrin alpha-ps | 0.0112 | 0.0161 | 0.0236 |
Loa Loa (eye worm) | hypothetical protein | 0.0363 | 0.4095 | 0.4095 |
Toxoplasma gondii | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1267 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0377 | 0.4311 | 0.4311 |
Onchocerca volvulus | 0.013 | 0.0438 | 0.5 | |
Mycobacterium leprae | PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) | 0.013 | 0.0438 | 0.5 |
Brugia malayi | Integrin alpha pat-2 precursor | 0.048 | 0.5927 | 0.6659 |
Echinococcus granulosus | thymidylate synthase | 0.013 | 0.0438 | 0.0676 |
Echinococcus multilocularis | integrin beta 2 | 0.0496 | 0.618 | 1 |
Brugia malayi | Integrin alpha cytoplasmic region family protein | 0.0363 | 0.4095 | 0.46 |
Plasmodium falciparum | bifunctional dihydrofolate reductase-thymidylate synthase | 0.0183 | 0.1267 | 0.5 |
Brugia malayi | Integrin beta pat-3 precursor | 0.067 | 0.8901 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.0161 | 0.0161 |
Schistosoma mansoni | integrin beta subunit | 0.0395 | 0.4586 | 0.7729 |
Plasmodium vivax | bifunctional dihydrofolate reductase-thymidylate synthase, putative | 0.0183 | 0.1267 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.067 | 0.8901 | 0.8901 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.