Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Metabotropic glutamate receptor 1 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Glutamate receptor 2 precursor | 0.0034 | 0.2903 | 0.4211 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0039 | 0.4167 | 0.375 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0039 | 0.4167 | 0.375 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0039 | 0.4167 | 0.477 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0034 | 0.2903 | 0.2395 |
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0034 | 0.2903 | 0.2395 |
Schistosoma mansoni | glutamate receptor kainate | 0.0034 | 0.2903 | 0.3323 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.0056 | 0.8736 | 1 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0034 | 0.2903 | 0.3323 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0039 | 0.4167 | 0.375 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.0041 | 0.471 | 0.4332 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0039 | 0.4167 | 0.375 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0039 | 0.4167 | 0.375 |
Schistosoma mansoni | glutamate receptor kainate | 0.0034 | 0.2903 | 0.3323 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0034 | 0.2903 | 0.3323 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.0049 | 0.6893 | 1 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0039 | 0.4167 | 0.375 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.006 | 1 | 1 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.0041 | 0.471 | 0.5392 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0034 | 0.2903 | 0.2395 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 1 | 1 |
Echinococcus granulosus | glutamate receptor 2 | 0.0039 | 0.4167 | 0.375 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0039 | 0.4167 | 0.375 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0034 | 0.2903 | 0.3323 |
Loa Loa (eye worm) | glutamate receptor | 0.0049 | 0.6893 | 0.5622 |
Schistosoma mansoni | glutamate receptor kainate | 0.0034 | 0.2903 | 0.3323 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0034 | 0.2903 | 0.3323 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.0044 | 0.5628 | 0.8166 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0034 | 0.2903 | 0.4211 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.0041 | 0.471 | 0.4332 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0039 | 0.4167 | 0.375 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0039 | 0.4167 | 0.375 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | nM | In vitro metabolic stability of compound was tested in human liver microsomes; not determined | ChEMBL. | 15771457 |
IC50 (binding) | 0 nM | Inhibitory concentration against human metabotropic glutamate receptor; ND:Not determined | ChEMBL. | 15771457 |
IC50 (functional) | 0 nM | In vitro metabolic stability of compound was tested in human liver microsomes; not determined | ChEMBL. | 15771457 |
IC50 (binding) | = 2630 nM | Inhibitory concentration against rat metabotropic glutamate receptor 1 | ChEMBL. | 15771457 |
IC50 (binding) | = 2630 nM | Inhibitory concentration against rat metabotropic glutamate receptor 1 | ChEMBL. | 15771457 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.