Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | purinergic receptor P2X, ligand-gated ion channel, 7 | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | carbohydrate phosphorylase | 0.0215 | 0.2901 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0215 | 0.2901 | 1 |
Mycobacterium tuberculosis | Probable purine nucleoside phosphorylase DeoD (inosine phosphorylase) (PNP) | 0.0123 | 0.0718 | 1 |
Trypanosoma brucei | RNA helicase, putative | 0.0515 | 1 | 0.5 |
Echinococcus multilocularis | Glycosyl transferase, family 35 | 0.0215 | 0.2901 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Mycobacterium leprae | Probable purine nucleoside phosphorylase DeoD (INOSINE PHOSPHORYLASE) (PNP) | 0.0123 | 0.0718 | 0.5 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Onchocerca volvulus | Glycogen phosphorylase homolog | 0.0215 | 0.2901 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.0718 |
Loa Loa (eye worm) | glycogen phosphorylase | 0.0215 | 0.2901 | 1 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0215 | 0.2901 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0215 | 0.2901 | 1 |
Echinococcus granulosus | Glycosyl transferase family 35 | 0.0215 | 0.2901 | 1 |
Trichomonas vaginalis | glycogen phosphorylase, putative | 0.0215 | 0.2901 | 1 |
Entamoeba histolytica | glycogen phosphorylase, putative | 0.0215 | 0.2901 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Schistosoma mansoni | glycogen phosphorylase | 0.0215 | 0.2901 | 0.2901 |
Schistosoma mansoni | glycogen phosphorylase | 0.0215 | 0.2901 | 0.2901 |
Echinococcus granulosus | glycogen phosphorylase | 0.0215 | 0.2901 | 1 |
Echinococcus multilocularis | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Echinococcus multilocularis | glycogen phosphorylase | 0.0215 | 0.2901 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Giardia lamblia | Glycogen phosphorylase | 0.0215 | 0.2901 | 1 |
Mycobacterium ulcerans | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Chlamydia trachomatis | glycogen phosphorylase | 0.0215 | 0.2901 | 0.5 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Schistosoma mansoni | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.0718 |
Echinococcus granulosus | glycogen phosphorylase | 0.0215 | 0.2901 | 1 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Echinococcus granulosus | purine nucleoside phosphorylase | 0.0123 | 0.0718 | 0.2173 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (functional) | = 6.9 | Antagonist activity at human P2X7 receptor expressed in human U373 cells assessed as inhibition of BzATP-induced Yo-Pro uptake | ChEMBL. | 19191585 |
IC50 (functional) | = 0.12 uM | Inhibitory concentration against YOPRO-1 dye uptake in U373MG cells stably expressing human P2X purinoceptor 7 using fluorescence assay | ChEMBL. | 15603968 |
IC50 (functional) | = 0.12 uM | Inhibitory concentration against YOPRO-1 dye uptake in U373MG cells stably expressing human P2X purinoceptor 7 using fluorescence assay | ChEMBL. | 15603968 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 15603968 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.