Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | proteasome subunit beta type-5, putative | 0.0223 | 0.1462 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | prolyl oligopeptidase | 0.0178 | 0.0659 | 0.0659 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0523 | 0.6904 | 0.6904 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.6904 | 0.6904 |
Trichomonas vaginalis | Family T1, proteasome beta subunit, threonine peptidase | 0.0223 | 0.1462 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0695 | 1 | 1 |
Brugia malayi | prolyl oligopeptidase family protein | 0.0178 | 0.0659 | 0.0659 |
Schistosoma mansoni | subfamily S9B unassigned peptidase (S09 family) | 0.0178 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | proteasome A-type and B-type family protein | 0.0223 | 0.1462 | 0.1462 |
Echinococcus granulosus | proteasome prosome macropain | 0.0223 | 0.1462 | 0.1462 |
Leishmania major | hypothetical protein, conserved | 0.0695 | 1 | 1 |
Brugia malayi | Proteasome A-type and B-type family protein | 0.0223 | 0.1462 | 0.1462 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0523 | 0.6904 | 0.6904 |
Echinococcus multilocularis | dipeptidyl aminopeptidaseprotein | 0.0178 | 0.0659 | 0.0659 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0695 | 1 | 1 |
Onchocerca volvulus | 0.0382 | 0.4341 | 0.4341 | |
Onchocerca volvulus | Dipeptidyl peptidase family member 1 homolog | 0.0178 | 0.0659 | 0.0659 |
Brugia malayi | Kringle domain containing protein | 0.0695 | 1 | 1 |
Mycobacterium leprae | proteasome (beta subunit) PrcB | 0.0223 | 0.1462 | 0.5 |
Schistosoma mansoni | proteasome catalytic subunit 3 (T01 family) | 0.0223 | 0.1462 | 0.1462 |
Loa Loa (eye worm) | hypothetical protein | 0.0695 | 1 | 1 |
Mycobacterium ulcerans | proteasome PrcB | 0.0223 | 0.1462 | 1 |
Echinococcus multilocularis | proteasome (prosome, macropain) | 0.0223 | 0.1462 | 0.1462 |
Giardia lamblia | Proteasome subunit beta type 5 precursor | 0.0223 | 0.1462 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0695 | 1 | 1 |
Mycobacterium tuberculosis | Proteasome beta subunit PrcB; assembles with alpha subunit PrcA. | 0.0223 | 0.1462 | 0.5 |
Echinococcus granulosus | dipeptidyl aminopeptidaseprotein | 0.0178 | 0.0659 | 0.0659 |
Schistosoma mansoni | hypothetical protein | 0.0695 | 1 | 1 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0695 | 1 | 1 |
Toxoplasma gondii | kringle domain-containing protein | 0.0695 | 1 | 1 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0695 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0523 | 0.6904 | 0.6904 |
Brugia malayi | Trypsin family protein | 0.0523 | 0.6904 | 0.6904 |
Onchocerca volvulus | 0.0695 | 1 | 1 | |
Entamoeba histolytica | proteasome subunit beta type 5 precursor, putative | 0.0223 | 0.1462 | 0.5 |
Onchocerca volvulus | 0.0523 | 0.6904 | 0.6904 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1.45 ug ml-1 | Compound was evaluated for antimicrobial activity against Helicobacter pylori | ChEMBL. | 9871756 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.